The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Published in Nature structural & molecular biology (01.06.2017)
Published in Nature structural & molecular biology (01.06.2017)
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Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
Ranjbarvaziri, Sara, Kooiker, Kristina B., Ellenberger, Mathew, Fajardo, Giovanni, Zhao, Mingming, Vander Roest, Alison Schroer, Woldeyes, Rahel A., Koyano, Tiffany T., Fong, Robyn, Ma, Ning, Tian, Lei, Traber, Gavin M., Chan, Frandics, Perrino, John, Reddy, Sushma, Chiu, Wah, Wu, Joseph C., Woo, Joseph Y., Ruppel, Kathleen M., Spudich, James A., Snyder, Michael P., Contrepois, Kévin, Bernstein, Daniel
Published in Circulation (New York, N.Y.) (23.11.2021)
Published in Circulation (New York, N.Y.) (23.11.2021)
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Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
Kawana, Masataka, Spudich, James A, Ruppel, Kathleen M
Published in Frontiers in physiology (26.09.2022)
Published in Frontiers in physiology (26.09.2022)
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Journal Article
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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Cryo-EM structure of the folded-back state of human β-cardiac myosin
Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien
Published in Nature communications (31.05.2023)
Published in Nature communications (31.05.2023)
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Journal Article
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
Morck, Makenna M, Bhowmik, Debanjan, Pathak, Divya, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Published in eLife (29.06.2022)
Published in eLife (29.06.2022)
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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin
Sommese, Ruth F, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M
Published in PloS one (18.12.2013)
Published in PloS one (18.12.2013)
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Journal Article
Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level
Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M., Spudich, James A.
Published in Nature structural & molecular biology (01.06.2018)
Published in Nature structural & molecular biology (01.06.2018)
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Journal Article
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
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The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches
Trivedi, Darshan V, Nag, Suman, Spudich, Annamma, Ruppel, Kathleen M, Spudich, James A
Published in Annual review of biochemistry (20.06.2020)
Published in Annual review of biochemistry (20.06.2020)
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Journal Article
Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
Roest, Alison Schroer Vander, Liu, Chao, Morck, Makenna M., Kooiker, Kristina Bezold, Jung, Gwanghyun, Song, Dan, Dawood, Aminah, Jhingran, Arnav, Pardon, Gaspard, Ranjbarvaziri, Sara, Fajardo, Giovanni, Zhao, Mingming, Campbell, Kenneth S., Pruitt, Beth L., Spudich, James A., Ruppel, Kathleen M., Bernstein, Daniel
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2021)
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Journal Article
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
Liu, Chao, Karabina, Anastasia, Meller, Artur, Bhattacharjee, Ayan, Agostino, Colby J, Bowman, Greg R, Ruppel, Kathleen M, Spudich, James A, Leinwand, Leslie A
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2024)
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Journal Article
Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation
Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M., Olivotto, Iacopo, Bustamante, Carlos D., Dewey, Frederick E., Ho, Carolyn Y., Spudich, James A., Ashley, Euan A.
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2016)
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Journal Article
Dilated cardiomyopathy myosin mutants have reduced force-generating capacity
Ujfalusi, Zoltan, Vera, Carlos D., Mijailovich, Srbolujub M., Svicevic, Marina, Yu, Elizabeth Choe, Kawana, Masataka, Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Published in The Journal of biological chemistry (08.06.2018)
Published in The Journal of biological chemistry (08.06.2018)
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Journal Article
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Journal Article
Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties
Vera, Carlos D., Johnson, Chloe A., Walklate, Jonathan, Adhikari, Arjun, Svicevic, Marina, Mijailovich, Srboljub M., Combs, Ariana C., Langer, Stephen J., Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Published in The Journal of biological chemistry (15.11.2019)
Published in The Journal of biological chemistry (15.11.2019)
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