Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors
Rupniak, Nadia M J, Perdona, Elisabetta, Griffante, Cristiana, Cavallini, Palmina, Sava, Anna, Ricca, Daniel J, Thor, Karl B, Burgard, Edward C, Corsi, Mauro
Published in PloS one (25.10.2018)
Published in PloS one (25.10.2018)
Get full text
Journal Article
Effect of GR205171 on autonomic dysreflexia induced by colorectal distension in spinal cord injured rats
Rupniak, Nadia M J, Fernandes, Silvia, Hou, Shaoping, Thor, Karl B, Marson, Lesley
Published in Spinal cord (01.09.2023)
Published in Spinal cord (01.09.2023)
Get full text
Journal Article
Colorectal and bladder prokinetic activity of [Lys 5 , MeLeu 9 , Nle 10 ]-NKA (4-10) after intranasal or sublingual delivery in dogs
Rupniak, Nadia M J, Katofiasc, Mary A, Bae, Jungeun, Thor, Karl B, Marson, Lesley
Published in Canadian journal of physiology and pharmacology (01.04.2023)
Published in Canadian journal of physiology and pharmacology (01.04.2023)
Get full text
Journal Article
Prokinetic effects of the neurokinin NK2 receptor agonist [Lys5,MeLeu9,Nle10]-NKA(4–10) on bladder and colorectal activity in minipigs
Rupniak, Nadia M.J., Katofiasc, Mary A., Marson, Lesley, Ricca, Daniel J., Thor, Karl B., Burgard, Edward C.
Published in Neuropeptides (Edinburgh) (01.10.2019)
Published in Neuropeptides (Edinburgh) (01.10.2019)
Get full text
Journal Article
Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives
Meurer, Laura C., Finke, Paul E., Owens, Karen A., Tsou, Nancy N., Ball, Richard G., Mills, Sander G., MacCoss, Malcolm, Sadowski, Sharon, Cascieri, Margaret A., Tsao, Kwei-Lan, Chicchi, Gary G., Egger, Linda A., Luell, Silvi, Metzger, Joseph M., MacIntyre, D. Euan, Rupniak, Nadia M.J., Williams, Angela R., Hargreaves, Richard J.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Get full text
Journal Article
Substance P (Neurokinin 1) Receptor Antagonists Enhance Dorsal Raphe Neuronal Activity
Conley, Rachel K, Cumberbatch, Michael J, Mason, Glenn S, Williamson, David J, Harrison, Timothy, Locker, Karen, Swain, Christopher, Maubach, Karen, O'Donnell, Ruth, Rigby, Michael, Hewson, Louise, Smith, David, Rupniak, Nadia M. J
Published in The Journal of neuroscience (01.09.2002)
Published in The Journal of neuroscience (01.09.2002)
Get full text
Journal Article
Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice
Morcuende, Sara, Gadd, Christopher A., Peters, Marco, Moss, Andrew, Harris, Elizabeth A., Sheasby, Anne, Fisher, Amy S., De Felipe, Carmen, Mantyh, Patrick W., Rupniak, Nadia M. J., Giese, K. Peter, Hunt, Stephen P.
Published in The European journal of neuroscience (01.10.2003)
Published in The European journal of neuroscience (01.10.2003)
Get full text
Journal Article
Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Finke, Paul E, Cascieri, Margaret A, Sadowski, Sharon, Ber, Elzbieta, Chicchi, Gary G, Kurtz, Marc, Metzger, Joseph, Eiermann, George, Tsou, Nancy N, Tattersall, F. David, Rupniak, Nadia M. J, Williams, Angela R, Rycroft, Wayne, Hargreaves, Richard, MacIntyre, D. Euan
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
Get full text
Journal Article
[Lys 5 ,MeLeu 9 ,Nle 10 ]-NKA (4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs
Rupniak, Nadia M J, Katofiasc, Mary, Walz, Alexander, Thor, Karl B, Burgard, Edward C
Published in The Journal of pharmacology and experimental therapeutics (01.07.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2018)
Get full text
Journal Article
Potency, efficacy, and selectivity of GR64349 at human recombinant neurokinin NK2 and NK1 receptors
Perdona, Elisabetta, Cavallini, Palmina, Sava, Anna, Griffante, Cristiana, Ricca, Daniel J., Thor, Karl B., Rupniak, Nadia M.J., Corsi, Mauro
Published in Neuroscience letters (15.10.2019)
Published in Neuroscience letters (15.10.2019)
Get full text
Journal Article
Chronic psychosocial stress in tree shrews : effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters
VAN DER HART, Marieke G. C, DE BIURRUN, Gabriel, CZEH, Boldizsar, RUPNIAK, Nadia M. J, DEN BOER, Johan A, FUCHS, Eberhard
Published in Psychopharmacologia (01.09.2005)
Published in Psychopharmacologia (01.09.2005)
Get full text
Journal Article
The Hypothalamic–Pituitary–Adrenal Axis and Serotonin Metabolism in Individual Brain Nuclei of Mice with Genetic Disruption of the NK1 Receptor Exposed to Acute Stress
Culman, Juraj, Mühlenhoff, Stephan, Blume, Annegret, Hedderich, Jürgen, Lützen, Ulf, Hunt, Stephen P., Rupniak, Nadia M. J., Zhao, Yi
Published in Cellular and molecular neurobiology (01.08.2018)
Published in Cellular and molecular neurobiology (01.08.2018)
Get full text
Journal Article
Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
Kramer, Mark S., Cutler, Neal, Feighner, John, Shrivastava, Ram, Carman, John, Sramek, John J., Reines, Scott A., Liu, Guanghan, Snavely, Duane, Wyatt-Knowles, Edwina, Hale, Jeffrey J., Mills, Sander G., MacCoss, Malcolm, Swain, Christopher J., Harrison, Timothy, Hill, Raymond G., Hefti, Franz, Scolnick, Edward M., Cascieri, Margaret A., Chicchi, Gary G., Sadowski, Sharon, Williams, Angela R., Hewson, Louise, Smith, David, Carlson, Emma J., Hargreaves, Richard J., Nadia M. J. Rupniak
Published in Science (American Association for the Advancement of Science) (11.09.1998)
Published in Science (American Association for the Advancement of Science) (11.09.1998)
Get full text
Journal Article
The bradykinin B1 receptor antagonist B9858 inhibits a nociceptive spinal reflex in rabbits
Mason, Glenn S, Cumberbatch, Michael J, Hill, Raymond G, Rupniak, Nadia MJ
Published in Canadian journal of physiology and pharmacology (01.04.2002)
Published in Canadian journal of physiology and pharmacology (01.04.2002)
Get full text
Journal Article
Conference Proceeding