Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.
Published in Nature genetics (01.10.2020)
Published in Nature genetics (01.10.2020)
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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel
Published in Nature communications (15.08.2018)
Published in Nature communications (15.08.2018)
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Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease
Strauss, Katrin, Goebel, Cornelia, Runz, Heiko, Möbius, Wiebke, Weiss, Sievert, Feussner, Ivo, Simons, Mikael, Schneider, Anja
Published in The Journal of biological chemistry (20.08.2010)
Published in The Journal of biological chemistry (20.08.2010)
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Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells
Ebrahimi-Fakhari, Darius, Wahlster, Lara, Bartz, Fabian, Werenbeck-Ueding, Jennifer, Praggastis, Maria, Zhang, Jessie, Joggerst-Thomalla, Brigitte, Theiss, Susanne, Grimm, Dirk, Ory, Daniel S, Runz, Heiko
Published in Human molecular genetics (15.08.2016)
Published in Human molecular genetics (15.08.2016)
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Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake
Zimoń, Magdalena, Huang, Yunfeng, Trasta, Anthi, Halavatyi, Aliaksandr, Liu, Jimmy Z., Chen, Chia-Yen, Blattmann, Peter, Klaus, Bernd, Whelan, Christopher D., Sexton, David, John, Sally, Huber, Wolfgang, Tsai, Ellen A., Pepperkok, Rainer, Runz, Heiko
Published in Nature communications (05.11.2021)
Published in Nature communications (05.11.2021)
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PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs
Vochteloo, Martijn, Deelen, Patrick, Vink, Britt, Tsai, Ellen A, Runz, Heiko, Andreu-Sánchez, Sergio, Fu, Jingyuan, Zhernakova, Alexandra, Westra, Harm-Jan, Franke, Lude
Published in Genome Biology (22.01.2024)
Published in Genome Biology (22.01.2024)
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Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank
Hillary, Robert F., Gadd, Danni A., Kuncheva, Zhana, Mangelis, Tasos, Lin, Tinchi, Ferber, Kyle, McLaughlin, Helen, Runz, Heiko, Marioni, Riccardo E., Foley, Christopher N., Sun, Benjamin B.
Published in Nature communications (26.08.2024)
Published in Nature communications (26.08.2024)
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Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome
Baird, Denis A, Liu, Jimmy Z, Zheng, Jie, Sieberts, Solveig K, Perumal, Thanneer, Elsworth, Benjamin, Richardson, Tom G, Chen, Chia-Yen, Carrasquillo, Minerva M, Allen, Mariet, Reddy, Joseph S, De Jager, Philip L, Ertekin-Taner, Nilufer, Mangravite, Lara M, Logsdon, Ben, Estrada, Karol, Haycock, Philip C, Hemani, Gibran, Runz, Heiko, Smith, George Davey, Gaunt, Tom R
Published in PLoS genetics (08.01.2021)
Published in PLoS genetics (08.01.2021)
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Development of a bile acid-based newborn screen for Niemann-Pick disease type C
Jiang, Xuntian, Sidhu, Rohini, Mydock-McGrane, Laurel, Hsu, Fong-Fu, Covey, Douglas F, Scherrer, David E, Earley, Brian, Gale, Sarah E, Farhat, Nicole Y, Porter, Forbes D, Dietzen, Dennis J, Orsini, Joseph J, Berry-Kravis, Elizabeth, Zhang, Xiaokui, Reunert, Janice, Marquardt, Thorsten, Runz, Heiko, Giugliani, Roberto, Schaffer, Jean E, Ory, Daniel S
Published in Science translational medicine (04.05.2016)
Published in Science translational medicine (04.05.2016)
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Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression
Tian, Ruoyu, Ge, Tian, Kweon, Hyeokmoon, Rocha, Daniel B., Lam, Max, Liu, Jimmy Z., Singh, Kritika, Levey, Daniel F., Gelernter, Joel, Stein, Murray B., Tsai, Ellen A., Huang, Hailiang, Chabris, Christopher F., Lencz, Todd, Runz, Heiko, Chen, Chia-Yen
Published in Nature communications (26.02.2024)
Published in Nature communications (26.02.2024)
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Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials
Loomis, Stephanie J., Sadhu, Nilanjana, Fisher, Elizabeth, Gafson, Arie R., Huang, Yunfeng, Yang, Chengran, Hughes, Emily E., Marshall, Eric, Herman, Ann, John, Sally, Runz, Heiko, Jia, Xiaoming, Bhangale, Tushar, Bronson, Paola G.
Published in Scientific reports (31.08.2023)
Published in Scientific reports (31.08.2023)
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Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding
Iskar, Murat, Zeller, Georg, Blattmann, Peter, Campillos, Monica, Kuhn, Michael, Kaminska, Katarzyna H, Runz, Heiko, Gavin, Anne‐Claude, Pepperkok, Rainer, van Noort, Vera, Bork, Peer
Published in Molecular systems biology (2013)
Published in Molecular systems biology (2013)
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Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials
Cortina-Borja, Mario, Te Vruchte, Danielle, Mengel, Eugen, Amraoui, Yasmin, Imrie, Jackie, Jones, Simon A, I Dali, Christine, Fineran, Paul, Kirkegaard, Thomas, Runz, Heiko, Lachmann, Robin, Bremova-Ertl, Tatiana, Strupp, Michael, Platt, Frances M
Published in Orphanet journal of rare diseases (16.08.2018)
Published in Orphanet journal of rare diseases (16.08.2018)
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Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology
Lam, Max, Chen, Chia-Yen, Hill, W. David, Xia, Charley, Tian, Ruoyu, Levey, Daniel F., Gelernter, Joel, Stein, Murray B., Hatoum, Alexander S., Huang, Hailiang, Malhotra, Anil K., Runz, Heiko, Ge, Tian, Lencz, Todd
Published in Nature communications (11.11.2022)
Published in Nature communications (11.11.2022)
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Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening
Bartz, Fabian, Kern, Luise, Erz, Dorothee, Zhu, Mingang, Gilbert, Daniel, Meinhof, Till, Wirkner, Ute, Erfle, Holger, Muckenthaler, Martina, Pepperkok, Rainer, Runz, Heiko
Published in Cell metabolism (01.07.2009)
Published in Cell metabolism (01.07.2009)
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Genetic map of regional sulcal morphology in the human brain from UK biobank data
Sun, Benjamin B., Loomis, Stephanie J., Pizzagalli, Fabrizio, Shatokhina, Natalia, Painter, Jodie N., Foley, Christopher N., Jensen, Megan E., McLaren, Donald G., Chintapalli, Sai Spandana, Zhu, Alyssa H., Dixon, Daniel, Islam, Tasfiya, Ba Gari, Iyad, Runz, Heiko, Medland, Sarah E., Thompson, Paul M., Jahanshad, Neda, Whelan, Christopher D.
Published in Nature communications (14.10.2022)
Published in Nature communications (14.10.2022)
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Rare genetic variants impact muscle strength
Huang, Yunfeng, Bodnar, Dora, Chen, Chia-Yen, Sanchez-Andrade, Gabriela, Sanderson, Mark, Shi, Jun, Meilleur, Katherine G., Hurles, Matthew E., Gerety, Sebastian S., Tsai, Ellen A., Runz, Heiko
Published in Nature communications (10.06.2023)
Published in Nature communications (10.06.2023)
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Niemann-Pick disease type C clinical database: cognitive and coordination deficits are early disease indicators
Stampfer, Miriam, Theiss, Susanne, Amraoui, Yasmina, Jiang, Xuntian, Keller, Sigrid, Ory, Daniel S, Mengel, Eugen, Fischer, Christine, Runz, Heiko
Published in Orphanet journal of rare diseases (22.02.2013)
Published in Orphanet journal of rare diseases (22.02.2013)
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