MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance
Rauch, Nora, Rukhlenko, Oleksii S, Kolch, Walter, Kholodenko, Boris N
Published in Current opinion in structural biology (01.12.2016)
Published in Current opinion in structural biology (01.12.2016)
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Journal Article
Reversing pathological cell states: the road less travelled can extend the therapeutic horizon
Kholodenko, Boris N., Kolch, Walter, Rukhlenko, Oleksii S.
Published in Trends in cell biology (01.11.2023)
Published in Trends in cell biology (01.11.2023)
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Journal Article
A systematic analysis of signaling reactivation and drug resistance
Kholodenko, Boris N., Rauch, Nora, Kolch, Walter, Rukhlenko, Oleksii S.
Published in Cell reports (Cambridge) (25.05.2021)
Published in Cell reports (Cambridge) (25.05.2021)
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Journal Article
Control of cell state transitions
Rukhlenko, Oleksii S., Halasz, Melinda, Rauch, Nora, Zhernovkov, Vadim, Prince, Thomas, Wynne, Kieran, Maher, Stephanie, Kashdan, Eugene, MacLeod, Kenneth, Carragher, Neil O., Kolch, Walter, Kholodenko, Boris N.
Published in Nature (London) (29.09.2022)
Published in Nature (London) (29.09.2022)
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Journal Article
Mathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress
Rukhlenko, Oleksii S, Dudchenko, Olga A, Zlobina, Ksenia E, Guria, Georgy Th
Published in PloS one (29.07.2015)
Published in PloS one (29.07.2015)
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Journal Article
Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
Bolado-Carrancio, Alfonso, Rukhlenko, Oleksii S, Nikonova, Elena, Tsyganov, Mikhail A, Wheeler, Anne, Garcia-Munoz, Amaya, Kolch, Walter, von Kriegsheim, Alex, Kholodenko, Boris N
Published in eLife (24.07.2020)
Published in eLife (24.07.2020)
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Journal Article
Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells
Sevrin, Thomas, Imoto, Hiroaki, Robertson, Sarah, Rauch, Nora, Dyn’ko, Uscinnia, Koubova, Katerina, Wynne, Kieran, Kolch, Walter, Rukhlenko, Oleksii S., Kholodenko, Boris N.
Published in Cell reports (Cambridge) (24.09.2024)
Published in Cell reports (Cambridge) (24.09.2024)
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Journal Article
Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets
Rukhlenko, Oleksii S, Imoto, Hiroaki, Tambde, Ayush, McGillycuddy, Amy, Junk, Philipp, Tuliakova, Anna, Kolch, Walter, Kholodenko, Boris N
Published in Cancers (27.06.2024)
Published in Cancers (27.06.2024)
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Journal Article
Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor
Erickson, Keesha E, Rukhlenko, Oleksii S, Shahinuzzaman, Md, Slavkova, Kalina P, Lin, Yen Ting, Suderman, Ryan, Stites, Edward C, Anghel, Marian, Posner, Richard G, Barua, Dipak, Kholodenko, Boris N, Hlavacek, William S
Published in PLoS computational biology (01.01.2019)
Published in PLoS computational biology (01.01.2019)
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Journal Article
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Kennedy, Susan A., Jarboui, Mohamed-Ali, Srihari, Sriganesh, Raso, Cinzia, Bryan, Kenneth, Dernayka, Layal, Charitou, Theodosia, Bernal-Llinares, Manuel, Herrera-Montavez, Carlos, Krstic, Aleksandar, Matallanas, David, Kotlyar, Max, Jurisica, Igor, Curak, Jasna, Wong, Victoria, Stagljar, Igor, LeBihan, Thierry, Imrie, Lisa, Pillai, Priyanka, Lynn, Miriam A., Fasterius, Erik, Al-Khalili Szigyarto, Cristina, Breen, James, Kiel, Christina, Serrano, Luis, Rauch, Nora, Rukhlenko, Oleksii, Kholodenko, Boris N., Iglesias-Martinez, Luis F., Ryan, Colm J., Pilkington, Ruth, Cammareri, Patrizia, Sansom, Owen, Shave, Steven, Auer, Manfred, Horn, Nicola, Klose, Franziska, Ueffing, Marius, Boldt, Karsten, Lynn, David J., Kolch, Walter
Published in Nature communications (24.01.2020)
Published in Nature communications (24.01.2020)
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Journal Article
Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction
Thomaseth, Caterina, Fey, Dirk, Santra, Tapesh, Rukhlenko, Oleksii S., Radde, Nicole E., Kholodenko, Boris N.
Published in Scientific reports (01.11.2018)
Published in Scientific reports (01.11.2018)
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Journal Article
Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling
Rukhlenko, Oleksii S., Khorsand, Fahimeh, Krstic, Aleksandar, Rozanc, Jan, Alexopoulos, Leonidas G., Rauch, Nora, Erickson, Keesha E., Hlavacek, William S., Posner, Richard G., Gómez-Coca, Silvia, Rosta, Edina, Fitzgibbon, Cheree, Matallanas, David, Rauch, Jens, Kolch, Walter, Kholodenko, Boris N.
Published in Cell systems (22.08.2018)
Published in Cell systems (22.08.2018)
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Journal Article
A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression
Imoto, Hiroaki, Rauch, Nora, Neve, Ashish J, Khorsand, Fahimeh, Kreileder, Martina, Alexopoulos, Leonidas G, Rauch, Jens, Okada, Mariko, Kholodenko, Boris N, Rukhlenko, Oleksii S
Published in Biomolecules (Basel, Switzerland) (02.08.2023)
Published in Biomolecules (Basel, Switzerland) (02.08.2023)
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Journal Article
On the chemotherapeutic agents localization in tissue by means of snake venoms
Rukhlenko, Oleksii S, Guria, Georgy Th, Vorobiev, Andrey I
Published in Medical hypotheses (01.07.2017)
Published in Medical hypotheses (01.07.2017)
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Journal Article
Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages
Yabaji, Shivraj M., Rukhlenko, Oleksii S., Chatterjee, Sujoy, Bhattacharya, Bidisha, Wood, Emily, Kasaikina, Marina, Kholodenko, Boris N., Gimelbrant, Alexander A., Kramnik, Igor
Published in Science advances (29.09.2023)
Published in Science advances (29.09.2023)
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Journal Article
Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
Chatterjee, Sujoy, Yabaji, Shivraj M., Rukhlenko, Oleksii S., Bhattacharya, Bidisha, Waligurski, Emily, Vallavoju, Nandini, Ray, Somak, Kholodenko, Boris N., Brown, Lauren E., Beeler, Aaron B., Ivanov, Alexander R., Kobzik, Lester, Porco, John A., Kramnik, Igor
Published in iScience (20.08.2021)
Published in iScience (20.08.2021)
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