Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy
Leung, Elaine Lai-Han, Li, Run-Ze, Fan, Xing-Xing, Wang, Lily Yan, Wang, Yan, Jiang, Zebo, Huang, Jumin, Pan, Hu-Dan, Fan, Yue, Xu, Hongmei, Wang, Feng, Rui, Haopeng, Wong, Piu, Sumatoh, Hermi, Fehlings, Michael, Nardin, Alessandra, Gavine, Paul, Zhou, Longen, Cao, Yabing, Liu, Liang
Published in Nature communications (22.08.2023)
Published in Nature communications (22.08.2023)
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Journal Article
Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea
Ritchie, Jennifer M, Rui, Haopeng, Zhou, Xiaohui, Iida, Tetsuya, Kodoma, Toshio, Ito, Susuma, Davis, Brigid M, Bronson, Roderick T, Waldor, Matthew K
Published in PLoS pathogens (01.03.2012)
Published in PLoS pathogens (01.03.2012)
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Journal Article
Back to the future: studying cholera pathogenesis using infant rabbits
Ritchie, Jennifer M, Rui, Haopeng, Bronson, Roderick T, Waldor, Matthew K
Published in mBio (18.05.2010)
Published in mBio (18.05.2010)
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Journal Article
1383 Preclinical characterization of D3L-002, a novel cancer immunotherapy bispecific antibody that elicits potent anti-tumor efficacy via co-blocking TIGIT and PVRIG
Rui, Haopeng, Yang, Baotian, Yang, Xiaofeng, Zheng, Zhiqiang, Chen, Zhiqiang, Lu, Jingtao, Wu, Peggy, Wang, Jia, Chen, Janet, Wang, Allison, Chen, George
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Role of Alkaline Serine Protease, Asp, in Vibrio alginolyticus Virulence and Regulation of Its Expression by LuxO-LuxR Regulatory System
Rui, Haopeng, East China University of Science and Technology, Shanghai, P. R. China, Liu, Qin, East China University of Science and Technology, Shanghai, P. R. China, Wang, Qiyao, East China University of Science and Technology, Shanghai, P. R. China, Ma, Yue, East China University of Science and Technology, Shanghai, P. R. China, Liu, Huan, East China University of Science and Technology, Shanghai, P. R. China, Shi, Cunbin, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Science, Guangzhou, P. R. China, Zhang, Yuanxing, East China University of Science and Technology, Shanghai, P. R. China
Published in Journal of microbiology and biotechnology (01.05.2009)
Published in Journal of microbiology and biotechnology (01.05.2009)
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Journal Article
Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins
Rui, Haopeng, Ritchie, Jennifer M, Bronson, Roderick T, Mekalanos, John J, Zhang, Yuanxing, Waldor, Matthew K
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
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Journal Article
Identification of a luxO-regulated extracellular protein Pep and its roles in motility in Vibrio alginolyticus
Cao, Xiaodan, Wang, Qiyao, Liu, Qin, Rui, Haopeng, Liu, Huan, Zhang, Yuanxing
Published in Microbial pathogenesis (01.02.2011)
Published in Microbial pathogenesis (01.02.2011)
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Journal Article
D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities
Zhang, Jing, Lim, Sun Min, Yu, Mi Ra, Chen, Cheng, Wang, Jia, Wang, Wenqian, Rui, Haopeng, Lu, Jingtao, Lu, Shun, Mok, Tony, Chen, Zhi Jian, Cho, Byoung Chul
Published in Cancer discovery (04.09.2024)
Published in Cancer discovery (04.09.2024)
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Abstract C064: Combination of D3L-002, an anti-TIGIT/PVRIG bispecific antibody, with D3S-001, a KRAS G12C inhibitor, transformed tumor microenvironment from “cold” to “hot” and achieved durable tumor remission in preclinical models
Chen, George, Zhang, Jing, Rui, Haopeng, Yang, Xiaofeng, Wang, Tienan
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
D3S-001, a highly potent, selective, and differentiated covalent inhibitor of KRAS G12C: Human dose prediction and first‐in‐human (FIH) trial design
Lu, Jingtao, Zhang, Jing, Zheng, Zhiqiang, Chen, Cheng, Wang, Jia, Chen, Janet, Lu, Jiang, Rui, Haopeng, Wang, Allison, Chen, Zhi Jian
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Preclinical characterization of D3S-001, a highly potent, selective, and differentiated covalent inhibitor of KRAS G12C
Zhang, Jing, Wu, Wentao, Xu, Yangyang, Qian, Yi, Xia, Yuanfeng, Lu, Jiang, Zheng, Zhiqiang, Lu, Jingtao, Chen, Janet, Chen, Chase, Wang, Jia, Chen, Cheng, Rui, Haopeng, Wang, Allison, Jin, John, Chen, Zhi Jian
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Abstract 1267: Combination therapy of JNJ-67856633, a novel, first-in-class MALT1 protease inhibitor, and JNJ-64264681, a novel BTK inhibitor, for the treatment of B-cell lymphomas
Philippar, Ulrike, Fontan, Lorena, Cornelissen, Ivo, Rui, Haopeng, Balasubramanian, Sriram, Gaudiano, Marcello, Bekkers, Mariette, Van Nuffel, Luc, Lu, Tianbao, Wiener, John, Tichenor, Mark, Greway, Tony, Packman, Kathryn, Verbist, Bie, Elsayed, Yusri, Attar, Ricardo, Bussolari, Jacqueline, Gerecitano, John
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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A case study of a bispecific antibody manufacturability assessment and optimization during discovery stage and its implications
Wang, Shuang, Zhang, Weijie, Yang, Baotian, Zhang, Xudong, Fang, Jing, Rui, Haopeng, Chen, Zhijian, Gu, Jijie, Chen, Zhiqiang, Xu, Jianqing
Published in Antibody therapeutics (01.07.2024)
Published in Antibody therapeutics (01.07.2024)
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Journal Article
Role of Alkaline Serine Protease, Asp, in Vibrio alginolyticus Virulence and Regulation of Its Expression by LuxO-LuxR Regulatory System
Rui, Haopeng, Liu, Qin, Wang, Qiyao, Ma, Yue, Liu, Huan, Shi, Cunbin, Zhang, Yuanxing
Published in Journal of microbiology and biotechnology (30.05.2009)
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Published in Journal of microbiology and biotechnology (30.05.2009)
Journal Article
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
Abstract 6503: D3S-001, a second-generation GDP-bound KRAS G12C inhibitor, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities
Zhang, Jing, Lim, Sun Min, Yu, Mi Ra, Chen, Cheng, Wang, Jia, Wang, Wenqian, Rui, Haopeng, Lu, Jingtao, Lu, Shun, Mok, Tony, Chen, Zhi Jian, Cho, Byoung Chul
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 5690: Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B cell lymphomas
Philippar, Ulrike, Lu, Tianbao, Vloemans, Nele, Bekkers, Mariette, Van Nuffel, Luc, Gaudiano, Marcello, Wnuk-Lipinska, Katarzyna, Van Der Leede, Bas-jan, Amssoms, Katie, Kimpe, Kristof, Medaer, Bart, Greway, Tony, Abraham, Yann, Cummings, Max, Trella, Emanuele, Vanhoof, Greet, Sun, Weimei, Thuring, Jan Willem, Connolly, Peter, Linders, Jan, Rui, Haopeng, Balasubramanian, Sriram, Johnson, Amy, Gerecitano, John, Goldberg, Jenna, Edwards, James P., Elsayed, Yusri, Smit, Jennifer, Bussolari, Jaqueline, Attar, Ricardo
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 1873: D3L-001, a novel bispecific antibody targeting HER2 and CD47, demonstrates potent preclinical efficacy in solid tumors
Rui, Haopeng, Yang, Xiaofeng, Chen, Jiahao, Wang, Jia, Zheng, Zhiqiang, Chen, Zhiqiang, Lu, Jingtao, Wu, Peggy, Chen, Janet, Wang, Allison, Chen, George
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 5501: Vertical inhibition of the MAPK pathway with D3S-002, a potent and selective ERK1/2 inhibitor, to improve anti-tumor activity of and overcome resistance to KRAS G12C inhibitors
Zhang, Jing, Lu, Jingtao, Zheng, Zhiqiang, Lu, Jiang, Wang, Allison, Wang, Jia, Chen, Janet, Rui, Haopeng, Chen, Cheng, Chen, Zhi Jian
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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