Selection, synthesis, and structure–activity relationship of tetrahydropyrido[4,3- d]pyrimidine-2,4-diones as human GnRH receptor antagonists
Lanier, Marion C., Feher, Miklos, Ashweek, Neil J., Loweth, Colin J., Rueter, Jaimie K., Slee, Deborah H., Williams, John P., Zhu, Yun-Fei, Sullivan, Susan K., Brown, Michael S.
Published in Bioorganic & medicinal chemistry (15.08.2007)
Published in Bioorganic & medicinal chemistry (15.08.2007)
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Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy
Slee, Deborah H, Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents
Slee, Deborah H, Chen, Yongsheng, Zhang, Xiaohu, Moorjani, Manisha, Lanier, Marion C, Lin, Emily, Rueter, Jaimie K, Williams, John P, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships
Slee, Deborah H, Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties
Regan, Colin F., Guo, Zhiqiang, Chen, Yongsheng, Huang, Charles Q., Chen, Mi, Jiang, Wanlong, Rueter, Jaimie K., Coon, Timothy, Chen, Chen, Saunders, John, Brown, Michael S., Betz, Steve F., Struthers, R. Scott, Yang, Chun, Wen, Jenny, Madan, Ajay, Zhu, Yun-Fei
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Journal Article
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists
XIAOHU ZHANG, RUETER, Jaimie K, MARKISON, Stacy, JOSWIG, Tanya, MALANY, Siobhan, SANTOS, Mark, CASTRO-PALOMINO, Julio C, CRESPO, Maria I, PRAT, Maria, GUAL, Silvia, DIAZ, José-Luis, SAUNDERS, John, YONGSHENG CHEN, SLEE, Deborah H, MOORJANI, Manisha, LANIER, Marion C, LIN, Emily, GROSS, Raymond S, TELLEW, John E, WILLIAMS, John P, LECHNER, Sandra M
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability
Moorjani, Manisha, Luo, Zhiyong, Lin, Emily, Vong, Binh G, Chen, Yongsheng, Zhang, Xiaohu, Rueter, Jaimie K, Gross, Raymond S, Lanier, Marion C, Tellew, John E, Williams, John P, Lechner, Sandra M, Malany, Siobhan, Santos, Mark, Crespo, María I, Díaz, José-Luis, Saunders, John, Slee, Deborah H
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
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Journal Article
2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A2A antagonists with improved solubility and metabolic stability
MOORJANI, Manisha, ZHIYONG LUO, WILLIAMS, John P, LECHNER, Sandra M, MALANY, Siobhan, SANTOS, Mark, CRESPO, Maria I, DIAZ, José-Luis, SAUNDERS, John, SLEE, Deborah H, LIN, Emily, VONG, Binh G, YONGSHENG CHEN, XIAOHU ZHANG, RUETER, Jaimie K, GROSS, Raymond S, LANIER, Marion C, TELLEW, John E
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
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Journal Article
2,6-Diaryl-4-phenacylaminopyrimidines as potent and selective adenosine A(2A) antagonists with reduced hERG liability
Moorjani, Manisha, Zhang, Xiaohu, Chen, Yongsheng, Lin, Emily, Rueter, Jaimie K, Gross, Raymond S, Lanier, Marion C, Tellew, John E, Williams, John P, Lechner, Sandra M, Malany, Siobhan, Santos, Mark, Ekhlassi, Paddi, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Saunders, John, Slee, Deborah H
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Journal Article
2,6-Diaryl-4-phenacylaminopyrimidines as potent and selective adenosine A2A antagonists with reduced hERG liability
MOORJANI, Manisha, XIAOHU ZHANG, MALANY, Siobhan, SANTOS, Mark, EKHLASSI, Paddi, CASTRO-PALOMINO, Julio C, CRESPO, Maria I, PRAT, Maria, GUAL, Silvia, DIAZ, José-Luis, SAUNDERS, John, SLEE, Deborah H, YONGSHENG CHEN, LIN, Emily, RUETER, Jaimie K, GROSS, Raymond S, LANIER, Marion C, TELLEW, John E, WILLIAMS, John P, LECHNER, Sandra M
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Journal Article
Conformational analyses of sandostatin analogs containing stereochemical changes in positions 6 or 8
Mattern, Ralph-Heiko, Zhang, Li, Rueter, Jaimie K., Goodman, Murray
Published in BIOPOLYM (01.05.2000)
Published in BIOPOLYM (01.05.2000)
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2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF
FAIRFAX DAVID J, MCELLIGOTT DAVID L, REISCH HELGE A, DAHL RUSSELL S, CHRISTENSON ERIK, FOWLER KERRY W, BEATON GRAHAM, BOURDON LISA H, BERTINO JAIMIE A, GOLDMAN PHYLLIS, HUANG DANWEN, ZHICHKIN PAVEL E, HERENDEEN DAN, SONG REN HUA, RUETER JAIMIE K, MOREE WILNA J, JIANG QIN, DEMAGGIO ANTHONY J
Year of Publication 02.11.2009
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Year of Publication 02.11.2009
Patent
2-amino-N-pyrimidin-4-ylacetamides as A(2A) receptor antagonists: 1. Structure-activity relationships and optimization of heterocyclic substituents
Slee, Deborah H., Chen, Yongsheng, Zhang, Xiaohu, Moorjani, Manisha, Lanier, Marion C., Lin, Emily, Rueter, Jaimie K., Williams, John P., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Santos, Mark, Gross, Raymond S., Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A(2A) receptor antagonists with in vivo efficacy
Slee, Deborah H., Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Wen, Jenny, O'Brien, Zhihong, Saunders, John
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
2-amino-N-pyrimidin-4-ylacetamides as A(2A) receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships
Slee, Deborah H., Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Samos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, Maria I., Prat, Maria, Gual, Silvia, Diaz, Jose-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O'Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
2-Amino- N -pyrimidin-4-ylacetamides as A 2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships
Slee, Deborah H., Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Rueter, Jaimie K., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S., Williams, John P., Castro-Palomino, Julio C., Crespo, María I., Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John
Published in Journal of medicinal chemistry (01.03.2008)
Published in Journal of medicinal chemistry (01.03.2008)
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Journal Article
2-Amino- N -pyrimidin-4-ylacetamides as A 2A Receptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents
Slee, Deborah H., Chen, Yongsheng, Zhang, Xiaohu, Moorjani, Manisha, Lanier, Marion C., Lin, Emily, Rueter, Jaimie K., Williams, John P., Lechner, Sandra M., Markison, Stacy, Malany, Siobhan, Santos, Mark, Gross, Raymond S., Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Castro-Palomino, Julio C., Crespo, María I., Prat, Maria, Gual, Silvia, Díaz, José-Luis, Saunders, John
Published in Journal of medicinal chemistry (01.03.2008)
Published in Journal of medicinal chemistry (01.03.2008)
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Journal Article
2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A sub(2A) antagonists with improved solubility and metabolic stability
Moorjani, Manisha, Luo, Zhiyong, Lin, Emily, Vong, Binh G, Chen, Yongsheng, Zhang, Xiaohu, Rueter, Jaimie K, Gross, Raymond S, Lanier, Marion C, Tellew, John E, Williams, John P, Lechner, Sandra M, Malany, Siobhan, Santos, Mark, Crespo, Maria I, Diaz, Jose-Luis, Saunders, John, Slee, Deborah H
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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