Automated design of ligands to polypharmacological profiles
BESNARD, Jeremy, FILIPPO RUDA, Gian, SIMEONS, Frederick R. C, STOJANOVSKI, Laste, PRAT, Annik, SEIDAH, Nabil G, CONSTAM, Daniel B, RICHARD BICKERTON, G, READ, Kevin D, WETSEL, William C, GILBERT, Ian H, ROTH, Bryan L, SETOLA, Vincent, HOPKINS, Andrew L, ABECASSIS, Keren, RODRIGUIZ, Ramona M, HUANG, Xi-Ping, NORVAL, Suzanne, SASSANO, Maria F, SHIN, Antony I, WEBSTER, Lauren A
Published in Nature (London) (13.12.2012)
Published in Nature (London) (13.12.2012)
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Journal Article
The structural basis of fatty acid elongation by the ELOVL elongases
Nie, Laiyin, Pascoa, Tomas C, Pike, Ashley C W, Bushell, Simon R, Quigley, Andrew, Ruda, Gian Filippo, Chu, Amy, Cole, Victoria, Speedman, David, Moreira, Tiago, Shrestha, Leela, Mukhopadhyay, Shubhashish M M, Burgess-Brown, Nicola A, Love, James D, Brennan, Paul E, Carpenter, Elisabeth P
Published in Nature structural & molecular biology (01.06.2021)
Published in Nature structural & molecular biology (01.06.2021)
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Journal Article
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells
Tumber, Anthony, Nuzzi, Andrea, Hookway, Edward S., Hatch, Stephanie B., Velupillai, Srikannathasan, Johansson, Catrine, Kawamura, Akane, Savitsky, Pavel, Yapp, Clarence, Szykowska, Aleksandra, Wu, Na, Bountra, Chas, Strain-Damerell, Claire, Burgess-Brown, Nicola A., Ruda, Gian Filippo, Fedorov, Oleg, Munro, Shonagh, England, Katherine S., Nowak, Radoslaw P., Schofield, Christopher J., La Thangue, Nicholas B., Pawlyn, Charlotte, Davies, Faith, Morgan, Gareth, Athanasou, Nick, Müller, Susanne, Oppermann, Udo, Brennan, Paul E.
Published in Cell chemical biology (16.03.2017)
Published in Cell chemical biology (16.03.2017)
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Journal Article
Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging
Miao, Jianzhuang, Cui, Huaqing, Jin, Jing, Lai, Fangfang, Wen, Hui, Zhang, Xiang, Ruda, Gian Filippo, Chen, Xiaoguang, Yin, Dali
Published in Chemical communications (Cambridge, England) (18.01.2015)
Published in Chemical communications (Cambridge, England) (18.01.2015)
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Journal Article
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays
Le Bihan, Yann-Vaï, Lanigan, Rachel M., Atrash, Butrus, McLaughlin, Mark G., Velupillai, Srikannathasan, Malcolm, Andrew G., England, Katherine S., Ruda, Gian Filippo, Mok, N. Yi, Tumber, Anthony, Tomlin, Kathy, Saville, Harry, Shehu, Erald, McAndrew, Craig, Carmichael, LeAnne, Bennett, James M., Jeganathan, Fiona, Eve, Paul, Donovan, Adam, Hayes, Angela, Wood, Francesca, Raynaud, Florence I., Fedorov, Oleg, Brennan, Paul E., Burke, Rosemary, van Montfort, Rob L.M., Rossanese, Olivia W., Blagg, Julian, Bavetsias, Vassilios
Published in European journal of medicinal chemistry (01.09.2019)
Published in European journal of medicinal chemistry (01.09.2019)
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Journal Article
Acyclic Nucleoside Analogues as Inhibitors of Plasmodium falciparum dUTPase
NGUYEN, Corinne, RUDA, Gian Filippo, SCHIPANI, Alessandro, KASINATHAN, Ganasan, LEAL, Isabel, MUSSO-BUENDIA, Alexander, KAISER, Marcel, BRUN, Reto, RUIZ-PéREZ, Luis M., SAHLBERG, Britt-Louise, JOHANSSON, Nils Gunnar, GONZáLEZ-PACANOWSKA, Dolores, GILBERT, Ian H.
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Journal Article
Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase
Recio, Eliseo, Musso-Buendía, Alexander, Vidal, Antonio E., Ruda, Gian Filippo, Kasinathan, Ganasan, Nguyen, Corinne, Ruiz-Pérez, Luis Miguel, Gilbert, Ian H., González-Pacanowska, Dolores
Published in European journal of medicinal chemistry (01.08.2011)
Published in European journal of medicinal chemistry (01.08.2011)
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Journal Article
Assessing histone demethylase inhibitors in cells: lessons learned
Hatch, Stephanie B., Yapp, Clarence, Montenegro, Raquel C., Savitsky, Pavel, Gamble, Vicki, Tumber, Anthony, Ruda, Gian Filippo, Bavetsias, Vassilios, Fedorov, Oleg, Atrash, Butrus, Raynaud, Florence, Lanigan, Rachel, Carmichael, LeAnne, Tomlin, Kathy, Burke, Rosemary, Westaway, Susan M., Brown, Jack A., Prinjha, Rab K., Martinez, Elisabeth D., Oppermann, Udo, Schofield, Christopher J., Bountra, Chas, Kawamura, Akane, Blagg, Julian, Brennan, Paul E., Rossanese, Olivia, Müller, Susanne
Published in Epigenetics & chromatin (01.03.2017)
Published in Epigenetics & chromatin (01.03.2017)
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Journal Article
Synthesis and Biological Evaluation of Phosphate Prodrugs of 4-Phospho-D -erythronohydroxamic Acid, an Inhibitor of 6-Phosphogluconate Dehydrogenase
Ruda, Gian Filippo, Alibu, Vincent P., Mitsos, Christos, Bidet, Olivier, Kaiser, Marcel, Brun, Reto, Barrett, Michael P., Gilbert, Ian H.
Published in ChemMedChem (13.08.2007)
Published in ChemMedChem (13.08.2007)
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Journal Article
A New, Rapid, General Procedure for the Synthesis of Organic Molecules Supported on Methoxy-Polyethylene Glycol (MeOPEG) under Microwave Irradiation Conditions
Porcheddu, Andrea, Ruda, Gian Filippo, Sega, Alessandro, Taddei, Maurizio
Published in European journal of organic chemistry (01.03.2003)
Published in European journal of organic chemistry (01.03.2003)
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Journal Article
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P, Aimon, Anthony, Amitai, Gabriel, Bellini, Dom, Bennett, James, Fairhead, Michael, Fedorov, Oleg, Gabizon, Ronen, Gan, Jin, Guo, Jingxu, Plotnikov, Alexander, Reznik, Nava, Ruda, Gian Filippo, Díaz-Sáez, Laura, Straub, Verena M, Szommer, Tamas, Velupillai, Srikannathasan, Zaidman, Daniel, Zhang, Yanling, Coker, Alun R, Dowson, Christopher G, Barr, Haim M, Wang, Chu, Huber, Kilian V.M, Brennan, Paul E, Ovaa, Huib, von Delft, Frank, London, Nir
Published in Journal of the American Chemical Society (05.06.2019)
Published in Journal of the American Chemical Society (05.06.2019)
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Journal Article
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
Dong, Yin Yao, Pike, Ashley C. W., Mackenzie, Alexandra, McClenaghan, Conor, Aryal, Prafulla, Dong, Liang, Quigley, Andrew, Grieben, Mariana, Goubin, Solenne, Mukhopadhyay, Shubhashish, Ruda, Gian Filippo, Clausen, Michael V., Cao, Lishuang, Brennan, Paul E., Burgess-Brown, Nicola A., Sansom, Mark S. P., Tucker, Stephen J., Carpenter, Elisabeth P.
Published in Science (American Association for the Advancement of Science) (13.03.2015)
Published in Science (American Association for the Advancement of Science) (13.03.2015)
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Journal Article
Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification
Falchi, Federico, Bertozzi, Sine Mandrup, Ottonello, Giuliana, Ruda, Gian Filippo, Colombano, Giampiero, Fiorelli, Claudio, Martucci, Cataldo, Bertorelli, Rosalia, Scarpelli, Rita, Cavalli, Andrea, Bandiera, Tiziano, Armirotti, Andrea
Published in Analytical chemistry (Washington) (04.10.2016)
Published in Analytical chemistry (Washington) (04.10.2016)
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Journal Article
Design, Synthesis, Structure–Activity Relationship Studies, and Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) Modeling of a Series of O‑Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase
De Simone, Alessio, Russo, Debora, Ruda, Gian Filippo, Micoli, Alessandra, Ferraro, Mariarosaria, Di Martino, Rita Maria Concetta, Ottonello, Giuliana, Summa, Maria, Armirotti, Andrea, Bandiera, Tiziano, Cavalli, Andrea, Bottegoni, Giovanni
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Journal Article
8‑Substituted Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
Bavetsias, Vassilios, Lanigan, Rachel M, Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G, Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J, Jeganathan, Fiona, Hatch, Stephanie B, Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S, Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M, Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A, von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I, Westaway, Susan M, Prinjha, Rab K, Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J, Westwood, Isaac M, Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M, Brennan, Paul E, Blagg, Julian
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Journal Article
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase
De Simone, Alessio, Ruda, Gian Filippo, Albani, Clara, Tarozzo, Glauco, Bandiera, Tiziano, Piomelli, Daniele, Cavalli, Andrea, Bottegoni, Giovanni
Published in Chemical communications (Cambridge, England) (18.05.2014)
Published in Chemical communications (Cambridge, England) (18.05.2014)
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Journal Article
Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds
Ruda, Gian Filippo, Wong, Pui Ee, Alibu, Vincent P, Norval, Suzanne, Read, Kevin D, Barrett, Michael P, Gilbert, Ian H
Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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Journal Article
Deregulation of Chromosome Segregation and Cancer
Curtis, Natalie L, Ruda, Gian Filippo, Brennan, Paul, Bolanos-Garcia, Victor M
Published in Annual review of cancer biology (04.03.2020)
Published in Annual review of cancer biology (04.03.2020)
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Journal Article
N‑Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
Fang, Wenxia, Robinson, David A, Raimi, Olawale G, Blair, David E, Harrison, Justin R, Lockhart, Deborah E. A, Torrie, Leah S, Ruda, Gian Filippo, Wyatt, Paul G, Gilbert, Ian H, van Aalten, Daan M. F
Published in ACS chemical biology (19.06.2015)
Published in ACS chemical biology (19.06.2015)
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