Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
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Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors
Jílková, Adéla, Rubešová, Petra, Fanfrlík, Jindřich, Fajtová, Pavla, Řezáčová, Pavlína, Brynda, Jiří, Lepšík, Martin, Mertlíková-Kaiserová, Helena, Emal, Cory D, Renslo, Adam R, Roush, William R, Horn, Martin, Caffrey, Conor R, Mareš, Michael
Published in ACS infectious diseases (14.05.2021)
Published in ACS infectious diseases (14.05.2021)
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1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β
Pomeislová, Alice, Otmar, Miroslav, Rubešová, Petra, Benýšek, Jakub, Matoušová, Marika, Mertlíková-Kaiserová, Helena, Pohl, Radek, Poštová Slavětínská, Lenka, Pomeisl, Karel, Krečmerová, Marcela
Published in Bioorganic & medicinal chemistry (15.02.2021)
Published in Bioorganic & medicinal chemistry (15.02.2021)
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Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni : Structural and Mechanistic Insights into Chemotype Reactivity
Jílková, Adéla, Horn, Martin, Fanfrlík, Jindřich, Küppers, Jim, Pachl, Petr, Řezáčová, Pavlína, Lepšík, Martin, Fajtová, Pavla, Rubešová, Petra, Chanová, Marta, Caffrey, Conor R, Gütschow, Michael, Mareš, Michael
Published in ACS infectious diseases (08.01.2021)
Published in ACS infectious diseases (08.01.2021)
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