Search Results - "Rozamus, Leonard W." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Redesigning an FKBP-Ligand Interface to Generate Chemical Dimerizers with Novel Specificity

Redesigning an FKBP-Ligand Interface to Generate Chemical Dimerizers with Novel Specificity

by Clackson, Tim, Yang, Wu, Rozamus, Leonard W., Hatada, Marcos, Amara, Jane F., Rollins, Carl T., Stevenson, Lauren F., Magari, Shannon R., Wood, Susan A., Courage, Nancy L., Lu, Xiaode, Cerasoli, Franklin, Gilman, Michael, Holt, Dennis A.
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.1998)

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Journal Article

Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients

Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients

by Zech, Stephan G, Carr, Michael, Mohemmad, Qurish K, Narasimhan, Narayana I, Murray, Christopher, Rozamus, Leonard W, Dalgarno, David C
Published in Journal of antibiotics (01.09.2011)

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Journal Article

Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer

Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer

by Rivera, Victor M., Gao, Guang-ping, Grant, Rebecca L., Schnell, Michael A., Zoltick, Philip W., Rozamus, Leonard W., Clackson, Tim, Wilson, James M.
Published in Blood (15.02.2005)

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Journal Article

5--N4-[2-]-N2-2--4-[4-4--1--1-]-24-CRYSTALLINE FORMS OF 5-CHLORO-N4-[2-DIMETHYLPHOSPHORYLPHENYL]-N2-2-METHOXY-4-[4-4-METHYLPIPERAZIN-1-YLPIPERIDIN-1-YL]PYRIMIDINE-24-DIAMINE

5--N4-[2-]-N2-2--4-[4-4--1--1-]-24-CRYSTALLINE FORMS OF 5-CHLORO-N4-[2-DIMETHYLPHOSPHORYLPHENYL]-N2-2-METHOXY-4-[4-4-METHYLPIPERAZIN-1-YLPIPERIDIN-1-YL]PYRIMIDINE-24-DIAMINE

by ROZAMUS LEONARD W, SHARMA PRADEEP
Year of Publication 27.06.2017

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Patent

Manipulation of the Rapamycin Effector Domain. Selective Nucleophilic Substitution of the C7 Methoxy Group

Manipulation of the Rapamycin Effector Domain. Selective Nucleophilic Substitution of the C7 Methoxy Group

by Luengo, Juan I, Konialian-Beck, Arda, Rozamus, Leonard W, Holt, Dennis A
Published in Journal of organic chemistry (01.11.1994)

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Journal Article

Investigating Protein−Ligand Interactions with a Mutant FKBP Possessing a Designed Specificity Pocket

Investigating Protein−Ligand Interactions with a Mutant FKBP Possessing a Designed Specificity Pocket

by Yang, Wu, Rozamus, Leonard W, Narula, Surinder, Rollins, Carl T, Yuan, Ruth, Andrade, Lawrence J, Ram, Mary K, Phillips, Thomas B, van Schravendijk, Marie Rose, Dalgarno, David, Clackson, Tim, Holt, Dennis A
Published in Journal of medicinal chemistry (23.03.2000)

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Journal Article

Design, synthesis, and kinetic evaluation of high-affinity FKBP ligands and the X-ray crystal structures of their complexes with FKBP12

Design, synthesis, and kinetic evaluation of high-affinity FKBP ligands and the X-ray crystal structures of their complexes with FKBP12

by Holt, Dennis A, Luengo, Juan I, Yamashita, Dennis S, Oh, Hye Ja, Konialian, Arda L, Yen, Hwa Kwo, Rozamus, Leonard W, Brandt, Martin, Bossard, Mary J
Published in Journal of the American Chemical Society (01.11.1993)

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Journal Article

Regulation of gene expression by synthetic dimerizers with novel specificity

Regulation of gene expression by synthetic dimerizers with novel specificity

by Yang, Wu, Keenan, Terence P., Rozamus, Leonard W., Wang, Xiurong, Rivera, Victor M., Rollins, Carl T., Clackson, Tim, Holt, Dennis A.
Published in Bioorganic & medicinal chemistry letters (06.10.2003)

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Journal Article

Selective Epimerization of Rapamycin via a Retroaldol/Aldol Mechanism Mediated by Titanium Tetraisopropoxide

Selective Epimerization of Rapamycin via a Retroaldol/Aldol Mechanism Mediated by Titanium Tetraisopropoxide

by Yang, Wu, Digits, Cheryl A, Hatada, Marcos, Narula, Surinder, Rozamus, Leonard W, Huestis, Cameran M, Wong, Jason, Dalgarno, David, Holt, Dennis A
Published in Organic letters (16.12.1999)

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Journal Article

Structure-activity studies of synthetic FKBP ligands as peptidyl-prolyl isomerase inhibitors

Structure-activity studies of synthetic FKBP ligands as peptidyl-prolyl isomerase inhibitors

by Holt, Dennis A., Konialian-Beck, Arda L., Oh, Hye-Ja, Yen, Hwa-Kwo, Rozamus, Leonard W., Krog, Arnold J., Erhard, Karl F., Ortiz, Elizabeth, Levy, Mark A., Brandt, Martin, Bossard, Mary J., Luengo, Juan I.
Published in Bioorganic & medicinal chemistry letters (01.01.1994)

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Journal Article

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4[(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PHENYL} PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4[(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PHENYL} PYRIMIDINE-2,4-DIAMINE

by Sharma, Pradeep, Rozamus, Leonard W
Year of Publication 08.02.2024

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Patent

Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl) phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl} pyrimidine-2,4-diamine

Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl) phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl} pyrimidine-2,4-diamine

by Sharma, Pradeep, Rozamus, Leonard W
Year of Publication 30.08.2022

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Patent

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PYRIMIDINE-2,4-DIAMINE

by SHARMA, PRADEEP, ROZAMUS, LEONARD, W
Year of Publication 09.08.2022

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Patent

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PHENYL} PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL] PHENYL} PYRIMIDINE-2,4-DIAMINE

by Sharma, Pradeep, Rozamus, Leonard W
Year of Publication 18.11.2021

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Patent

CRYSTALLINE FORMS OF 5-CHLORO-N4-[2-(DIMETHYLPHOSPHORYL)PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-[2-(DIMETHYLPHOSPHORYL)PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

by SHARMA, PRADEEP, ROZAMUS, LEONARD W
Year of Publication 16.11.2021

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Patent

Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl) phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl} pyrimidine-2,4-diamine

Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl) phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl} pyrimidine-2,4-diamine

by Sharma, Pradeep, Rozamus, Leonard W
Year of Publication 02.03.2021

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Patent

CRYSTALLINE FORMS OF 5-CHLORO-N4-(-2-(DIMETHYLPHOSPHORYL) PHENYL)-N2-(2-METHOXY-4-(4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL)PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-(-2-(DIMETHYLPHOSPHORYL) PHENYL)-N2-(2-METHOXY-4-(4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL)PYRIMIDINE-2,4-DIAMINE

by SHARMA Pradeep, ROZAMUS Leonard W
Year of Publication 29.01.2021

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Patent

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

by ROZAMUS, Leonard, W, SHARMA, Pradeep
Year of Publication 06.01.2021

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Patent

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

by Sharma, Pradeep, Rozamus, Leonard W
Year of Publication 27.11.2020

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Patent

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

CRYSTALLINE FORMS OF 5-CHLORO-N4-[-2-(DIMETHYLPHOSPHORYL) PHENYL]-N2-{2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL) PIPERIDIN-1-YL]PYRIMIDINE-2,4-DIAMINE

by SHARMA, PRADEEP, ROZAMUS, LEONARD, W
Year of Publication 30.09.2020

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Patent

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