Phase Ib study of duligotuzumab (MEHD7945A) plus cisplatin/5‐fluorouracil or carboplatin/paclitaxel for first‐line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck
Jimeno, Antonio, Machiels, Jean‐Pascal, Wirth, Lori, Specenier, Pol, Seiwert, Tanguy Y., Mardjuadi, Feby, Wang, Xiaodong, Kapp, Amy V., Royer‐Joo, Stephanie, Penuel, Elicia, McCall, Bruce, Pirzkall, Andrea, Clement, Paul M.
Published in Cancer (15.12.2016)
Published in Cancer (15.12.2016)
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Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
Nayak-Kapoor, Asha, Hao, Zhonglin, Sadek, Ramses, Dobbins, Robin, Marshall, Lisa, Vahanian, Nicholas N, Jay Ramsey, W, Kennedy, Eugene, Mautino, Mario R, Link, Charles J, Lin, Ray S, Royer-Joo, Stephanie, Liang, Xiaorong, Salphati, Laurent, Morrissey, Kari M, Mahrus, Sami, McCall, Bruce, Pirzkall, Andrea, Munn, David H, Janik, John E, Khleif, Samir N
Published in Journal for immunotherapy of cancer (20.06.2018)
Published in Journal for immunotherapy of cancer (20.06.2018)
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Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor
Ma, Shuguang, Suchomel, Julia, Yanez, Evelyn, Yost, Edward, Liang, Xiaorong, Zhu, Rui, Le, Hoa, Siebers, Nicholas, Joas, Lori, Morley, Roland, Royer‐Joo, Stephanie, Pirzkall, Andrea, Salphati, Laurent, Ware, Joseph A., Morrissey, Kari M.
Published in British journal of clinical pharmacology (01.08.2019)
Published in British journal of clinical pharmacology (01.08.2019)
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Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation
Sacher, Adrian, LoRusso, Patricia, Patel, Manish R., Miller, Wilson H., Garralda, Elena, Forster, Martin D., Santoro, Armando, Falcon, Alejandro, Kim, Tae Won, Paz-Ares, Luis, Bowyer, Samantha, de Miguel, Maria, Han, Sae-Won, Krebs, Matthew G., Lee, Jong-Seok, Cheng, Michael L., Arbour, Kathryn, Massarelli, Erminia, Choi, Yoonha, Shi, Zhen, Mandlekar, Sandhya, Lin, Mark T., Royer-Joo, Stephanie, Chang, Julie, Dharia, Neekesh V., Schutzman, Jennifer L., Desai, Jayesh
Published in The New England journal of medicine (24.08.2023)
Published in The New England journal of medicine (24.08.2023)
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An open-label phase I dose-escalation study of the safety and pharmacokinetics of DMUC4064A in patients with platinum-resistant ovarian cancer
Liu, Joyce, Burris, Howard, Wang, Judy S., Barroilhet, Lisa, Gutierrez, Martin, Wang, Yulei, Vaze, Anjali, Commerford, Renee, Royer-Joo, Stephanie, Choeurng, Voleak, Humke, Eric, Moore, Kathleen
Published in Gynecologic oncology (01.12.2021)
Published in Gynecologic oncology (01.12.2021)
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Circulating Tumor DNA Dynamics Reveal KRAS G12C Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors
Choi, Yoonha, Dharia, Neekesh V., Jun, Tomi, Chang, Julie, Royer-Joo, Stephanie, Yau, Kenneth K., Assaf, Zoe J., Aimi, Junko, Sivakumar, Smruthy, Montesion, Meagan, Sacher, Adrian, LoRusso, Patricia, Desai, Jayesh, Schutzman, Jennifer L., Shi, Zhen
Published in Clinical cancer research (03.09.2024)
Published in Clinical cancer research (03.09.2024)
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Journal Article
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
Desai, Jayesh, Alonso, Guzman, Kim, Se Hyun, Cervantes, Andres, Karasic, Thomas, Medina, Laura, Shacham-Shmueli, Einat, Cosman, Rasha, Falcon, Alejandro, Gort, Eelke, Guren, Tormod, Massarelli, Erminia, Miller, Jr, Wilson H, Paz-Ares, Luis, Prenen, Hans, Amatu, Alessio, Cremolini, Chiara, Kim, Tae Won, Moreno, Victor, Ou, Sai-Hong I, Passardi, Alessandro, Sacher, Adrian, Santoro, Armando, Stec, Rafal, Ulahannan, Susanna, Arbour, Kathryn, Lorusso, Patricia, Luo, Jia, Patel, Manish R, Choi, Yoonha, Shi, Zhen, Mandlekar, Sandhya, Lin, Mark T, Royer-Joo, Stephanie, Chang, Julie, Jun, Tomi, Dharia, Neekesh V, Schutzman, Jennifer L, Han, Sae-Won
Published in Nature medicine (01.01.2024)
Published in Nature medicine (01.01.2024)
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Phase I/Ib Trial of Inavolisib Plus Palbociclib and Endocrine Therapy for PIK3CA -Mutated, Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced or Metastatic Breast Cancer
Jhaveri, Komal L., Accordino, Melissa K., Bedard, Philippe L., Cervantes, Andrés, Gambardella, Valentina, Hamilton, Erika, Italiano, Antoine, Kalinsky, Kevin, Krop, Ian E., Oliveira, Mafalda, Schmid, Peter, Saura, Cristina, Turner, Nicholas C., Varga, Andrea, Cheeti, Sravanthi, Hilz, Stephanie, Hutchinson, Katherine E., Jin, Yanling, Royer-Joo, Stephanie, Peters, Ubong, Shankar, Noopur, Schutzman, Jennifer L., Juric, Dejan
Published in Journal of clinical oncology (05.09.2024)
Published in Journal of clinical oncology (05.09.2024)
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Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer
Gerber, David E, Infante, Jeffrey R, Gordon, Michael S, Goldberg, Sarah B, Martín, Miguel, Felip, Enriqueta, Martinez Garcia, Maria, Schiller, Joan H, Spigel, David R, Cordova, Julie, Westcott, Valerie, Wang, Yulei, Shames, David S, Choi, YounJeong, Kahn, Robert, Dere, Randall C, Samineni, Divya, Xu, Jian, Lin, Kedan, Wood, Katie, Royer-Joo, Stephanie, Lemahieu, Vanessa, Schuth, Eva, Vaze, Anjali, Maslyar, Daniel, Humke, Eric W, Burris, 3rd, Howard A
Published in Clinical cancer research (15.01.2020)
Published in Clinical cancer research (15.01.2020)
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Phase 1b study of anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) in patients with platinum-sensitive recurrent ovarian cancer
Moore, Kathleen N., Birrer, Michael J., Marsters, Jim, Wang, Yulei, Choi, YounJeong, Royer-Joo, Stephanie, Lemahieu, Vanessa, Armstrong, Katy, Cordova, Julie, Samineni, Divya, Schuth, Eva, Vaze, Anjali, Maslyar, Daniel, Humke, Eric W., Hamilton, Erika P., Liu, Joyce F.
Published in Gynecologic oncology (01.09.2020)
Published in Gynecologic oncology (01.09.2020)
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Abstract PS11-11: Targeted safety events from a phase I/Ib study evaluating GDC-0077 alone and in combination with endocrine therapy (ET) ± palbociclib (palbo) in patients (pts) with PIK3CA -mutant (mut), hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)
Olivera, Mafalda, Jhaveri, Komal, Juric, Dejan, Bedard, Philippe L, Cervantes, Andrés, Gambardella, Valentina, Hamilton, Erika, Italiano, Antoine, Kalinsky, Kevin, Krop, Ian E, Schmid, Peter, Turner, Nicolas, Varga, Andrea, Lei, Guiyuan, Royer-Joo, Stephanie, Thomas, Piia, Schutzman, Jennifer L, Saura, Cristina
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Long-term safety of inavolisib (GDC-0077) in an ongoing phase 1/1b study evaluating monotherapy and in combination (combo) with palbociclib and/or endocrine therapy in patients (pts) with PIK3CA -mutated, hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer (BC)
Bedard, Philippe L., Accordino, Melissa Kate, Cervantes, Andres, Gambardella, Valentina, Hamilton, Erika P., Italiano, Antoine, Juric, Dejan, Kalinsky, Kevin, Krop, Ian E., Oliveira, Mafalda, Saura, Cristina, Schmid, Peter, Turner, Nicholas C., Varga, Andreea, Shankar, Noopur, Schutzman, Jennifer, Royer-Joo, Stephanie, Martin, Miguel Valero, Jhaveri, Komal L.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Abstract P5-17-05: A phase I/Ib study of inavolisib (GDC-0077) in combination with fulvestrant in patients (pts) with PIK3CA -mutated hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer
Juric, Dejan, Bedard, Phillippe L, Cervantes, Andrés, Gambardella, Valentina, Oliveira, Mafalda, Saura, Cristina, Kalinsky, Kevin M, Hamilton, Erika, Italiano, Antoine, Krop, Ian E, Schmid, Peter, Turner, Nicholas C, Varga, Andrea, Royer-Joo, Stephanie, Hutchinson, Katherine E, Schutzman, Jennifer L, Jhaveri, Komal L
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Abstract PD1-02: A phase I/Ib study evaluating GDC-0077 + palbociclib (palbo) + fulvestrant in patients (pts) with PIK3CA -mutant (mut), hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)
Bedard, Philippe L, Jhaveri, Komal, Cervantes, Andrés, Gambardella, Valentina, Hamilton, Erika, Italiano, Antoine, Kalinsky, Kevin, Krop, Ian E, Oliveira, Mafalda, Saura, Cristina, Schmid, Peter, Turner, Nicolas, Varga, Andrea, Hutchinson, Katherine E, Lei, Guiyuan, Royer-Joo, Stephanie, Thomas, Piia, Schutzman, Jennifer L, Juric, Dejan
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Abstract PS5-12: Preliminary correlative analysis of clinical outcomes with PIK3CA mutation (mut) status from a phase I/Ib study of GDC-0077 in patients (pts) with hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)
Jhaveri, Komal, Juric, Dejan, Varga, Andrea, Turner, Nicolas, Schmid, Peter, Saura, Cristina, Oliveira, Mafalda, Krop, Ian E, Kalinsky, Kevin, Italiano, Antoine, Hamilton, Erika, Gambardella, Valentina, Cervantes, Andrés, Bedard, Philippe L, Liu, Bonnie P, Chen, Jessica W, Aimi, Junko, Royer-Joo, Stephanie, Schutzman, Jennifer L, Hutchinson, Katherine E
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Abstract CT109: A phase I/Ib study evaluating GDC-0077 plus fulvestrant in patients with PIK3CA -mutant, hormone receptor-positive/HER2-negative breast cancer
Kalinsky, Kevin, Juric, Dejan, Bedard, Philippe L., Oliveira, Mafalda, Cervantes, Andres, Hamilton, Erika, Krop, Ian E., Turner, Nick, Schmid, Peter, Varga, Andrea, Italiano, Antoine, Veitch, Zachary, Saura, Cristina, Gambardella, Valentina, Cheeti, Sravanthi, Kotani, Naoki, Lei, Guiyuan, Hutchinson, Katherine E., Royer-Joo, Stephanie, Vaze, Anjali, Schutzman, Jennifer L., Jhaveri, Komal
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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A Phase I Dose-Escalation Study Evaluating the Safety Tolerability and Pharmacokinetics of CUDC-427, a Potent, Oral, Monovalent IAP Antagonist, in Patients with Refractory Solid Tumors
Tolcher, Anthony W, Bendell, Johanna C, Papadopoulos, Kyriakos P, Burris, Howard A, Patnaik, Amita, Fairbrother, Wayne J, Wong, Harvey, Budha, Nageshwar, Darbonne, Walter C, Peale, Franklin, Mamounas, Michael, Royer-Joo, Stephanie, Yu, Ron, Portera, Chia C, Infante, Jeffrey R
Published in Clinical cancer research (15.09.2016)
Published in Clinical cancer research (15.09.2016)
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Abstract OT1-08-04: A first-in-human phase Ia dose escalation study of GDC-0077, a p110a-selective and mutant-degrading PI3K inhibitor, in patients with PIK3CA -mutant solid tumors
Juric, Dejan, Kalinsky, Kevin, Oliveira, Mafalda, Cervantes, Andres, Bedard, Philippe, Krop, Ian, Hamilton, Erika, Schmid, Peter, Varga, Andrea, Turner, Nick, Italiano, Antoine, Saura, Cristina, Gambardella, Valentina, Veitch, Zachary, Dickmann, Leslie, Kotani, Naoki, Fredrickson, Jill, Kapp, Amy, Hutchinson, Katie, Royer-Joo, Stephanie, Vaze, Anjali, Schutzman, Jennifer, Jhaveri, Komal
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Abstract P1-19-46: A phase Ib dose escalation study evaluating the mutant selective PI3K-alpha inhibitor GDC-0077 (G) in combination with letrozole (L) with and without palbociclib (P) in patients with PIK3CA -mutant HR+/HER2- breast cancer
Jhaveri, Komal, Kalinsky, Kevin, Bedard, Philippe, Cervantes, Andres, Saura, Cristina, Krop, Ian, Hamilton, Erika, Schmid, Peter, Varga, Andrea, Turner, Nick, Italiano, Antoine, Gambardella, Valentina, Veitch, Zachary, Oliveira, Mafalda, Dickmann, Leslie, Kotani, Naoki, Kapp, Amy, Hutchinson, Katie, Royer-Joo, Stephanie, Vaze, Anjali, Schutzman, Jennifer, Juric, Dejan
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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A Phase 1B Study of Dulanermin in Combination With Modified FOLFOX6 Plus Bevacizumab in Patients With Metastatic Colorectal Cancer
Wainberg, Zev A, Messersmith, Wells A, Peddi, Parvin F, Kapp, Amy V, Ashkenazi, Avi, Royer-Joo, Stephanie, Portera, Chia C, Kozloff, Mark F
Published in Clinical colorectal cancer (01.12.2013)
Published in Clinical colorectal cancer (01.12.2013)
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