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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Chen, Jinhua, Corr, Nicholas, dela Cruz-Chuh, Josefa, Del Rosario, Geoffrey, Fullerton, Aaron, Hartman, Steven J, Jiang, Fan, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liling, Lu, Ying, Mulvihill, Melinda M, Murray, Jeremy M, O’Donohue, Aimee, Rowntree, Rebecca K, Sawyer, William S, Staben, Leanna R, Wai, John, Wang, Jian, Wei, BinQing, Wei, Wentao, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Zhang, Hongyan, Zhang, Shenhua, Zhao, Yongxin, Zhou, Hao, Zhu, Xiaoyu
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties
Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Bhakta, Sunil, Blaquiere, Nicole, Chen, Jinhua, dela Cruz-Chuh, Josefa, Gascoigne, Karen E, Hartman, Steven J, He, Mingtao, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liang, Liu, Liling, Liu, Qi, Lu, Ying, Meng, Fanwei, Mulvihill, Melinda M, O’Donohue, Aimee, Rowntree, Rebecca K, Staben, Leanna R, Staben, Steven T, Wai, John, Wang, Jian, Wei, BinQing, Wilson, Catherine, Xin, Jianfeng, Xu, Zijin, Yao, Hui, Zhang, Donglu, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates
Staben, Leanna R, Chen, Jinhua, Cruz-Chuh, Josefa dela, del Rosario, Geoff, Go, Mary Ann, Guo, Jun, Khojasteh, S. Cyrus, Kozak, Katherine R, Li, Guangmin, Ng, Carl, Lewis Phillips, Gail D, Pillow, Thomas H, Rowntree, Rebecca K, Wai, John, Wei, BinQing, Xu, Keyang, Xu, Zijin, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response
Dela Cruz Chuh, Josefa, Go, MaryAnn, Chen, Yvonne, Guo, Jun, Rafidi, Hanine, Mandikian, Danielle, Sun, Yonglian, Lin, Zhonghua, Schneider, Kellen, Zhang, Pamela, Vij, Rajesh, Sharpnack, Danielle, Chan, Pamela, de la Cruz, Cecile, Sadowsky, Jack, Seshasayee, Dhaya, Koerber, James T., Pillow, Thomas H., Phillips, Gail D., Rowntree, Rebecca K, Boswell, C. Andrew, Kozak, Katherine R., Polson, Andrew G., Polakis, Paul, Yu, Shang-Fan, Dragovich, Peter S., Agard, Nicholas J.
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Higher order chromatin structure at the X-inactivation center via looping DNA
Tsai, Chia-Lun, Rowntree, Rebecca K., Cohen, Dena E., Lee, Jeannie T.
Published in Developmental biology (15.07.2008)
Published in Developmental biology (15.07.2008)
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LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity
Krishnamurty, Akshay T., Shyer, Justin A., Thai, Minh, Gandham, Vineela, Buechler, Matthew B., Yang, Yeqing Angela, Pradhan, Rachana N., Wang, Amber W., Sanchez, Patricia L., Qu, Yan, Breart, Beatrice, Chalouni, Cécile, Dunlap, Debra, Ziai, James, Elstrott, Justin, Zacharias, Neelie, Mao, Weiguang, Rowntree, Rebecca K., Sadowsky, Jack, Lewis, Gail D., Pillow, Thomas H., Nabet, Barzin Y., Banchereau, Romain, Tam, Lucinda, Caothien, Roger, Bacarro, Natasha, Roose-Girma, Merone, Modrusan, Zora, Mariathasan, Sanjeev, Müller, Sören, Turley, Shannon J.
Published in Nature (London) (03.11.2022)
Published in Nature (London) (03.11.2022)
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CTCF mediates insulator function at the CFTR locus
Blackledge, Neil P., Carter, Emma J., Evans, Joanne R., Lawson, Victoria, Rowntree, Rebecca K., Harris, Ann
Published in Biochemical journal (01.12.2007)
Published in Biochemical journal (01.12.2007)
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Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning
Gutteridge, Alex, Rukstalis, J. Michael, Ziemek, Daniel, Tié, Mark, Ji, Lin, Ramos-Zayas, Rebeca, Nardone, Nancy A., Norquay, Lisa D., Brenner, Martin B., Tang, Kim, McNeish, John D., Rowntree, Rebecca K.
Published in PloS one (13.02.2013)
Published in PloS one (13.02.2013)
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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)
Dragovich, Peter S., Adhikari, Pragya, Blake, Robert A., Blaquiere, Nicole, Chen, Jinhua, Cheng, Yun-Xing, den Besten, Willem, Han, Jinping, Hartman, Steven J., He, Jintang, He, Mingtao, Rei Ingalla, Ellen, Kamath, Amrita V., Kleinheinz, Tracy, Lai, Tommy, Leipold, Douglas D., Li, Chun Sing, Liu, Qi, Lu, Jiawei, Lu, Ying, Meng, Fanwei, Meng, Lingyao, Ng, Carl, Peng, Kaishan, Lewis Phillips, Gail, Pillow, Thomas H., Rowntree, Rebecca K., Sadowsky, Jack D., Sampath, Deepak, Staben, Leanna, Staben, Steven T., Wai, John, Wan, Kunpeng, Wang, Xinxin, Wei, BinQing, Wertz, Ingrid E., Xin, Jianfeng, Xu, Keyang, Yao, Hui, Zang, Richard, Zhang, Donglu, Zhou, Hao, Zhao, Yongxin
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides
Zacharias, Neelie, Podust, Vladimir N., Kajihara, Kimberly K., Leipold, Douglas, Del Rosario, Geoffrey, Thayer, Desiree, Dong, Emily, Paluch, Maciej, Fischer, David, Zheng, Kai, Lei, Corinna, He, Jintang, Ng, Carl, Su, Dian, Liu, Luna, Masih, Shabkhaiz, Sawyer, William, Tinianow, Jeff, Marik, Jan, Yip, Victor, Li, Guangmin, Chuh, Josefa, Morisaki, J. Hiroshi, Park, Summer, Zheng, Bing, Hernandez-Barry, Hilda, Loyet, Kelly M., Xu, Min, Kozak, Katherine R., Phillips, Gail Lewis, Shen, Ben-Quan, Wu, Cong, Xu, Keyang, Yu, Shang-Fan, Kamath, Amrita, Rowntree, Rebecca K., Reilly, Dorothea, Pillow, Thomas, Polson, Andrew, Schellenberger, Volker, Hazenbos, Wouter L. W., Sadowsky, Jack
Published in Chemical science (Cambridge) (16.03.2022)
Published in Chemical science (Cambridge) (16.03.2022)
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Site-Specific Dolasynthen Antibody–Drug Conjugates Exhibit Consistent Pharmacokinetic Profiles across a Wide Range of Drug-to-Antibody Ratios
Clardy, Susan M., Uttard, Alex, Du, Bingfan, Catcott, Kalli C., Lancaster, Kelly L., Ditty, Elizabeth, Sadowsky, Jack, Zurita, Jeffrey, Malli, Naniye, Qin, LiuLiang, Bradley, Stephen P., Avocetien, Kenneth, Carter, Tyler, Kim, Dokyong, Nazzaro, Mark, Xu, Ling, Pillow, Thomas H., Zacharias, Neelie T., Lewis, Gail D., Rowntree, Rebecca K., Iyengar, Radha, Lee, David H., Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Published in Molecular cancer therapeutics (03.01.2024)
Published in Molecular cancer therapeutics (03.01.2024)
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An Anti–CD22- seco -CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models
Yu, Shang-Fan, Lee, Donna W., Zheng, Bing, del Rosario, Geoffrey, Leipold, Douglas, Booler, Helen, Zhong, Fiona, Carrasco-Triguero, Montserrat, Hong, Kyu, Yan, Peter, Rowntree, Rebecca K., Schutten, Melissa M., Pillow, Thomas, Sadowsky, Jack D., Dragovich, Peter S., Polson, Andrew G.
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Antibody–Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo
Su, Dian, Chen, Jinhua, Cosino, Ely, dela Cruz-Chuh, Josefa, Davis, Helen, Del Rosario, Geoffrey, Figueroa, Isabel, Goon, Leanne, He, Jintang, Kamath, Amrita V, Kaur, Surinder, Kozak, Katherine R, Lau, Jeffrey, Lee, Donna, Lee, M. Violet, Leipold, Douglas, Liu, Luna, Liu, Peter, Lu, Guo-Liang, Nelson, Chris, Ng, Carl, Pillow, Thomas H, Polakis, Paul, Polson, Andrew G, Rowntree, Rebecca K, Saad, Ola, Safina, Brian, Stagg, Nicola J, Tercel, Moana, Vandlen, Richard, Vollmar, Breanna S, Wai, John, Wang, Tao, Wei, BinQing, Xu, Keyang, Xue, Juanjuan, Xu, Zijin, Yan, Gang, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Zhong, Fiona, Dragovich, Peter S
Published in Bioconjugate chemistry (15.05.2019)
Published in Bioconjugate chemistry (15.05.2019)
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Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody–Drug Conjugates
Pei, Zhonghua, Chen, Chunjiao, Chen, Jinhua, Cruz-Chuh, Josefa dela, Delarosa, Reginald, Deng, Yuzhong, Fourie-O’Donohue, Aimee, Figueroa, Isabel, Guo, Jun, Jin, Weiwei, Khojasteh, S. Cyrus, Kozak, Katherine R, Latifi, Brandon, Lee, James, Li, Guangmin, Lin, Eva, Liu, Liling, Lu, Jiawei, Martin, Scott, Ng, Carl, Nguyen, Trung, Ohri, Rachana, Lewis Phillips, Gail, Pillow, Thomas H, Rowntree, Rebecca K, Stagg, Nicola J, Stokoe, David, Ulufatu, Sheila, Verma, Vishal A, Wai, John, Wang, Jing, Xu, Keyang, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S
Published in Molecular pharmaceutics (04.09.2018)
Published in Molecular pharmaceutics (04.09.2018)
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Conjugation of Indoles to Antibodies through a Novel Self‐Immolating Linker
Dragovich, Peter S., Blake, Robert A., Chen, Chunjiao, Chen, Jinhua, Chuh, Josefa, den Besten, Willem, Fan, Fang, Fourie, Aimee, Hartman, Steven J., He, Changrong, He, Jintang, Ingalla, Ellen Rei, Kozak, Katherine R., Leong, Steven R., Lu, Jiawei, Ma, Yong, Meng, Lingyao, Nannini, Michelle, Oeh, Jason, Ohri, Rachana, Lewis Phillips, Gail, Pillow, Thomas H., Rowntree, Rebecca K., Sampath, Deepak, Vandlen, Richard, Vollmar, Breanna, Wai, John, Wertz, Ingrid E., Xu, Keyang, Xu, Zijin, Zhang, Donglu
Published in Chemistry : a European journal (03.04.2018)
Published in Chemistry : a European journal (03.04.2018)
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