Identification of 4‑(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)
Rowbottom, Martin W, Bain, Gretchen, Calderon, Imelda, Lasof, Taylor, Lonergan, David, Lai, Andiliy, Huang, Fei, Darlington, Janice, Prodanovich, Patricia, Santini, Angelina M, King, Christopher D, Goulet, Lance, Shannon, Kristen E, Ma, Gina L, Nguyen, Katherine, MacKenna, Deidre A, Evans, Jilly F, Hutchinson, John H
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX
Hutchinson, John H, Rowbottom, Martin W, Lonergan, David, Darlington, Janice, Prodanovich, Pat, King, Christopher D, Evans, Jilly F, Bain, Gretchen
Published in ACS medicinal chemistry letters (13.04.2017)
Published in ACS medicinal chemistry letters (13.04.2017)
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Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E
Rowbottom, Martin W, Faraoni, Raffaella, Chao, Qi, Campbell, Brian T, Lai, Andiliy G, Setti, Eduardo, Ezawa, Maiko, Sprankle, Kelly G, Abraham, Sunny, Tran, Lan, Struss, Brian, Gibney, Michael, Armstrong, Robert C, Gunawardane, Ruwanthi N, Nepomuceno, Ronald R, Valenta, Ianina, Hua, Helen, Gardner, Michael F, Cramer, Merryl D, Gitnick, Dana, Insko, Darren E, Apuy, Julius L, Jones-Bolin, Susan, Ghose, Arup K, Herbertz, Torsten, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce, Williams, Michael, Bhagwat, Shripad, James, Joyce, Holladay, Mark W
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity
James, Joyce, Ruggeri, Bruce, Armstrong, Robert C, Rowbottom, Martin W, Jones-Bolin, Susan, Gunawardane, Ruwanthi N, Dobrzanski, Pawel, Gardner, Michael F, Zhao, Hugh, Cramer, Merryl D, Hunter, Kathryn, Nepomuceno, Ronald R, Cheng, Mangeng, Gitnick, Dana, Yazdanian, Mehran, Insko, Darren E, Ator, Mark A, Apuy, Julius L, Faraoni, Raffaella, Dorsey, Bruce D, Williams, Michael, Bhagwat, Shripad S, Holladay, Mark W
Published in Molecular cancer therapeutics (01.04.2012)
Published in Molecular cancer therapeutics (01.04.2012)
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A Thienopyridazinone-Based Melanin-Concentrating Hormone Receptor 1 Antagonist with Potent in Vivo Anorectic Properties
Dyck, Brian, Markison, Stacy, Zhao, Liren, Tamiya, Junko, Grey, Jonathan, Rowbottom, Martin W, Zhang, Mingzhu, Vickers, Troy, Sorensen, Katie, Norton, Christi, Wen, Jenny, Heise, Christopher E, Saunders, John, Conlon, Paul, Madan, Ajay, Schwarz, David, Goodfellow, Val S
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
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Journal Article
Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists
Zhang, Mingzhu, Tamiya, Junko, Nguyen, Linh, Rowbottom, Martin W., Dyck, Brian, Vickers, Troy D., Grey, Jonathan, Schwarz, David A., Heise, Christopher E., Haelewyn, Jason, Mistry, Monica S., Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
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3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a Potent and Orally Active Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. Design, Synthesis, and in Vitro and in Vivo Characterization
Tucci, Fabio C, Zhu, Yun-Fei, Struthers, R. Scott, Guo, Zhiqiang, Gross, Timothy D, Rowbottom, Martin W, Acevedo, Oscar, Gao, Yinghong, Saunders, John, Xie, Qiu, Reinhart, Greg J, Liu, Xin-Jun, Ling, Nicholas, Bonneville, Anne K. L, Chen, Takung, Bozigian, Haig, Chen
Published in Journal of medicinal chemistry (24.02.2005)
Published in Journal of medicinal chemistry (24.02.2005)
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Journal Article
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors
Holladay, Mark W., Campbell, Brian T., Rowbottom, Martin W., Chao, Qi, Sprankle, Kelly G., Lai, Andiliy G., Abraham, Sunny, Setti, Eduardo, Faraoni, Raffaella, Tran, Lan, Armstrong, Robert C., Gunawardane, Ruwanthi N., Gardner, Michael F., Cramer, Merryl D., Gitnick, Dana, Ator, Mark A., Dorsey, Bruce D., Ruggeri, Bruce R., Williams, Michael, Bhagwat, Shripad S., James, Joyce
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists
Guo, Zhiqiang, Zhu, Yun-Fei, Gross, Timothy D, Tucci, Fabio C, Gao, Yinghong, Moorjani, Manisha, Connors, Patrick J, Rowbottom, Martin W, Chen, Yongsheng, Struthers, R. Scott, Xie, Qiu, Saunders, John, Reinhart, Greg, Chen, Ta Kung, Bonneville, Anne L. Killam, Chen
Published in Journal of medicinal chemistry (26.02.2004)
Published in Journal of medicinal chemistry (26.02.2004)
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Journal Article
Synthesis and structure–activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)
Rowbottom, Martin W., Vickers, Troy D., Tamiya, Junko, Zhang, Mingzhu, Dyck, Brian, Grey, Jonathan, Schwarz, David, Heise, Christopher E., Hedrick, Michael, Wen, Jenny, Tang, Hui, Wang, Hua, Fisher, Andrew, Aparicio, Anna, Saunders, John, Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Journal Article
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2
Hudson, Sarah, Kiankarimi, Mehrak, Rowbottom, Martin W., Vickers, Troy D., Wu, Dongpei, Pontillo, Joseph, Ching, Brett, Dwight, Wesley, Goodfellow, Val S., Schwarz, David, Heise, Christopher E., Madan, Ajay, Wen, Jenny, Ban, William, Wang, Hua, Wade, Warren S.
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Journal Article
Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists
Grey, Jonathan, Dyck, Brian, Rowbottom, Martin W, Tamiya, Junko, Vickers, Troy D, Zhang, Mingzhu, Zhao, Liren, Heise, Christopher E, Schwarz, David, Saunders, John, Goodfellow, Val S
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Journal Article
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1
Rowbottom, Martin W., Vickers, Troy D., Dyck, Brian, Grey, Jonathan, Tamiya, Junko, Zhang, Mingzhu, Kiankarimi, Mehrak, Wu, Dongpei, Dwight, Wesley, Wade, Warren S., Schwarz, David, Heise, Christopher E., Madan, Ajay, Fisher, Andrew, Petroski, Robert, Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article
3-(2-Aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl- uracils as Orally Bioavailable Antagonists of the Human Gonadotropin Releasing Hormone Receptor
Tucci, Fabio C, Zhu, Yun-Fei, Guo, Zhiqiang, Gross, Timothy D, Connors, Patrick J, Gao, Yinghong, Rowbottom, Martin W, Struthers, R. Scott, Reinhart, Greg J, Xie, Qiu, Chen, Ta Kung, Bozigian, Haig, Killam Bonneville, Anne L, Fisher, Andrew, Jin, Liping, Saunders, John, Chen
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Journal Article
Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers
Guo, Zhiqiang, Chen, Yongsheng, Huang, Charles Q., Gross, Timothy D., Pontillo, Joseph, Rowbottom, Martin W., Saunders, John, Struthers, Scott, Tucci, Fabio C., Xie, Qiu, Wade, Warren, Zhu, Yun-Fei, Wu, Dongpei, Chen, Chen
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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Journal Article
Synthesis and structure–activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)
Rowbottom, Martin W., Vickers, Troy D., Dyck, Brian, Tamiya, Junko, Zhang, Mingzhu, Zhao, Liren, Grey, Jonathan, Provencal, David, Schwarz, David, Heise, Christopher E., Mistry, Monica, Fisher, Andrew, Dong, Teresa, Hu, Tao, Saunders, John, Goodfellow, Val S.
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
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Journal Article
Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists
ROWBOTTOM, Martin W, TUCCI, Fabio C, ZHU, Yun-Fei, ZHIQIANG GUO, GROSS, Timothy D, REINHART, Greg J, QUI XIE, STRUTHERS, R. Scott, SAUNDERS, John, CHEN CHEN
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Journal Article
Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists
Guo, Zhiqiang, Wu, Dongpei, Zhu, Yun-Fei, Tucci, Fabio C., Regan, Collin F., Rowbottom, Martin W., Struthers, R. Scott, Xie, Qiu, Reijmers, Shelby, Sullivan, Susan K., Sai, Yang, Chen, Chen
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
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Journal Article
Synthesis and structure–activity relationships of uracil derived human GnRH receptor antagonists: ( R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5
Rowbottom, Martin W., Tucci, Fabio C., Connors, Patrick J., Gross, Timothy D., Zhu, Yun-Fei, Guo, Zhiqiang, Moorjani, Manisha, Acevedo, Oscar, Carter, Lee, Sullivan, Susan K., Xie, Qiu, Fisher, Andrew, Struthers, R. Scott, Saunders, John, Chen, Chen
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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Journal Article
Synthesis of vinyl epoxides via a three-component coupling
Rowbottom, M, Mathews, N, Gallagher, T
Published in Journal of the Chemical Society, Perkin Transactions 1 (07.12.1998)
Published in Journal of the Chemical Society, Perkin Transactions 1 (07.12.1998)
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