Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: Synthesis, antiviral activity and decomposition study
Roux, Loïc, Priet, Stéphane, Payrot, Nadine, Weck, Clément, Fournier, Maëlenn, Zoulim, Fabien, Balzarini, Jan, Canard, Bruno, Alvarez, Karine
Published in European journal of medicinal chemistry (01.05.2013)
Published in European journal of medicinal chemistry (01.05.2013)
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Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity
Lim, Wooi F, Forouhan, Mitra, Roberts, Thomas C, Dabney, Jesse, Ellerington, Ruth, Speciale, Alfina A, Manzano, Raquel, Lieto, Maria, Sangha, Gavinda, Banerjee, Subhashis, Conceição, Mariana, Cravo, Lara, Biscans, Annabelle, Roux, Loïc, Pourshafie, Naemeh, Grunseich, Christopher, Duguez, Stephanie, Khvorova, Anastasia, Pennuto, Maria, Cortes, Constanza J, La Spada, Albert R, Fischbeck, Kenneth H, Wood, Matthew J A, Rinaldi, Carlo
Published in Science advances (01.08.2021)
Published in Science advances (01.08.2021)
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RNAi modulation of placental sFLT1 for the treatment of preeclampsia
Turanov, Anton A, Lo, Agnes, Hassler, Matthew R, Makris, Angela, Ashar-Patel, Ami, Alterman, Julia F, Coles, Andrew H, Haraszti, Reka A, Roux, Loic, Godinho, Bruno M D C, Echeverria, Dimas, Pears, Suzanne, Iliopoulos, Jim, Shanmugalingam, Renuka, Ogle, Robert, Zsengeller, Zsuzsanna K, Hennessy, Annemarie, Karumanchi, S Ananth, Moore, Melissa J, Khvorova, Anastasia
Published in Nature biotechnology (01.12.2018)
Published in Nature biotechnology (01.12.2018)
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Journal Article
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia
Published in Nucleic acids research (16.03.2018)
Published in Nucleic acids research (16.03.2018)
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Journal Article
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Alterman, Julia F., Godinho, Bruno M. D. C., Hassler, Matthew R., Ferguson, Chantal M., Echeverria, Dimas, Sapp, Ellen, Haraszti, Reka A., Coles, Andrew H., Conroy, Faith, Miller, Rachael, Roux, Loic, Yan, Paul, Knox, Emily G., Turanov, Anton A., King, Robert M., Gernoux, Gwladys, Mueller, Christian, Gray-Edwards, Heather L., Moser, Richard P., Bishop, Nina C., Jaber, Samer M., Gounis, Matthew J., Sena-Esteves, Miguel, Pai, Athma A., DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Nature biotechnology (01.08.2019)
Published in Nature biotechnology (01.08.2019)
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Journal Article
Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles
Haraszti, Reka Agnes, Miller, Rachael, Didiot, Marie-Cecile, Biscans, Annabelle, Alterman, Julia F., Hassler, Matthew R., Roux, Loic, Echeverria, Dimas, Sapp, Ellen, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy (01.08.2018)
Published in Molecular therapy (01.08.2018)
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Journal Article
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Haraszti, Reka A, Roux, Loic, Davis, Sarah, Ly, Socheata, Echeverria, Dimas, Hassler, Matthew R, Godinho, Bruno M D C, Nikan, Mehran, Khvorova, Anastasia
Published in Nucleic acids research (20.02.2019)
Published in Nucleic acids research (20.02.2019)
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How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy
Pasquier, Amandine, Alais, Sandrine, Roux, Loic, Thoulouze, Maria-Isabel, Alvarez, Karine, Journo, Chloé, Dutartre, Hélène, Mahieux, Renaud
Published in Frontiers in microbiology (13.03.2018)
Published in Frontiers in microbiology (13.03.2018)
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Journal Article
5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
Haraszti, Reka A., Roux, Loic, Coles, Andrew H., Turanov, Anton A., Alterman, Julia F., Echeverria, Dimas, Godinho, Bruno M.D.C., Aronin, Neil, Khvorova, Anastasia
Published in Nucleic acids research (27.07.2017)
Published in Nucleic acids research (27.07.2017)
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Journal Article
5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
Haraszti, Reka A, Roux, Loic, Coles, Andrew H, Turanov, Anton A, Alterman, Julia F, Echeverria, Dimas, Godinho, Bruno M D C, Aronin, Neil, Khvorova, Anastasia
Published in Nucleic acids research (27.07.2017)
Published in Nucleic acids research (27.07.2017)
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Journal Article
Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles
Biscans, Annabelle, Haraszti, Reka A., Echeverria, Dimas, Miller, Rachael, Didiot, Marie-Cecile, Nikan, Mehran, Roux, Loic, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy (06.06.2018)
Published in Molecular therapy (06.06.2018)
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