TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau
Rousseaux, Maxime Wc, de Haro, Maria, Lasagna-Reeves, Cristian A, De Maio, Antonia, Park, Jeehye, Jafar-Nejad, Paymaan, Al-Ramahi, Ismael, Sharma, Ajay, See, Lauren, Lu, Nan, Vilanova-Velez, Luis, Klisch, Tiemo J, Westbrook, Thomas F, Troncoso, Juan C, Botas, Juan, Zoghbi, Huda Y
Published in eLife (25.10.2016)
Published in eLife (25.10.2016)
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Journal Article
Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala
Chen, Liqiang, Nagaraja, Chetan, Daniels, Samuel, Fisk, Zoe A, Dvorak, Rachel, Meyerdirk, Lindsay, Steiner, Jennifer A, Escobar Galvis, Martha L, Henderson, Michael X, Rousseaux, Maxime WC, Brundin, Patrik, Chu, Hong-Yuan
Published in eLife (01.07.2022)
Published in eLife (01.07.2022)
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Journal Article
Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau
Rousseaux, Maxime Wc, Revelli, Jean-Pierre, Vázquez-Vélez, Gabriel E, Kim, Ji-Yoen, Craigen, Evelyn, Gonzales, Kristyn, Beckinghausen, Jaclyn, Zoghbi, Huda Y
Published in eLife (04.06.2018)
Published in eLife (04.06.2018)
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Journal Article
A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1
Lasagna-Reeves, Cristian A, Rousseaux, Maxime Wc, Guerrero-Muñoz, Marcos J, Park, Jeehye, Jafar-Nejad, Paymaan, Richman, Ronald, Lu, Nan, Sengupta, Urmi, Litvinchuk, Alexandra, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Published in eLife (19.05.2015)
Published in eLife (19.05.2015)
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Journal Article
Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes
Lasagna-Reeves, Cristian A, Rousseaux, Maxime Wc, Guerrero-Munoz, Marcos J, Vilanova-Velez, Luis, Park, Jeehye, See, Lauren, Jafar-Nejad, Paymaan, Richman, Ronald, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Published in eLife (17.12.2015)
Published in eLife (17.12.2015)
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Journal Article
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
Lasagna-Reeves, Cristian A., de Haro, Maria, Hao, Shuang, Park, Jeehye, Rousseaux, Maxime W.C., Al-Ramahi, Ismael, Jafar-Nejad, Paymaan, Vilanova-Velez, Luis, See, Lauren, De Maio, Antonia, Nitschke, Larissa, Wu, Zhenyu, Troncoso, Juan C., Westbrook, Thomas F., Tang, Jianrong, Botas, Juan, Zoghbi, Huda Y.
Published in Neuron (Cambridge, Mass.) (19.10.2016)
Published in Neuron (Cambridge, Mass.) (19.10.2016)
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Journal Article
Disruption of the ATXN1–CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans
Lu, Hsiang-Chih, Tan, Qiumin, Rousseaux, Maxime W C, Wang, Wei, Kim, Ji-Yoen, Richman, Ronald, Wan, Ying-Wooi, Yeh, Szu-Ying, Patel, Jay M, Liu, Xiuyun, Lin, Tao, Lee, Yoontae, Fryer, John D, Han, Jing, Chahrour, Maria, Finnell, Richard H, Lei, Yunping, Zurita-Jimenez, Maria E, Ahimaz, Priyanka, Anyane-Yeboa, Kwame, Van Maldergem, Lionel, Lehalle, Daphne, Jean-Marcais, Nolwenn, Mosca-Boidron, Anne-Laure, Thevenon, Julien, Cousin, Margot A, Bro, Della E, Lanpher, Brendan C, Klee, Eric W, Alexander, Nora, Bainbridge, Matthew N, Orr, Harry T, Sillitoe, Roy V, Ljungberg, M Cecilia, Liu, Zhandong, Schaaf, Christian P, Zoghbi, Huda Y
Published in Nature genetics (01.04.2017)
Published in Nature genetics (01.04.2017)
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Journal Article
An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways
Jung, Sung Yun, Choi, Jong Min, Rousseaux, Maxime W.C., Malovannaya, Anna, Kim, Jean J., Kutzera, Joachim, Wang, Yi, Huang, Yin, Zhu, Weimin, Maity, Suman, Zoghbi, Huda Yahya, Qin, Jun
Published in Molecular & cellular proteomics (01.04.2017)
Published in Molecular & cellular proteomics (01.04.2017)
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Journal Article
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach
Rousseaux, Maxime W C, Vázquez-Vélez, Gabriel E, Al-Ramahi, Ismael, Jeong, Hyun-Hwan, Bajić, Aleksandar, Revelli, Jean-Pierre, Ye, Hui, Phan, Emily T, Deger, Jennifer M, Perez, Alma M, Kim, Ji-Yoen, Lavery, Laura A, Xu, Qikia, Li, Mamie Z, Kang, Hyojin, Kim, Jean J, Shulman, Joshua M, Westbrook, Thomas F, Elledge, Stephen J, Liu, Zhandong, Botas, Juan, Zoghbi, Huda Y
Published in The Journal of neuroscience (24.10.2018)
Published in The Journal of neuroscience (24.10.2018)
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Journal Article
Synaptic location is a determinant of the detrimental effects of [alpha]-synuclein pathology to glutamatergic transmission in the basolateral amygdala
Chen, Liqiang, Nagaraja, Chetan, Daniels, Samuel, Fisk, Zoe A, Dvorak, Rachel, Meyerdirk, Lindsay, Steiner, Jennifer A, Escobar Galvis, Martha L, Henderson, Michael X, Rousseaux, Maxime WC, Brundin, Patrik, Chu, Hong-Yuan
Published in eLife (01.07.2022)
Published in eLife (01.07.2022)
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Journal Article
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity
Vázquez-Vélez, Gabriel E, Gonzales, Kristyn A, Revelli, Jean-Pierre, Adamski, Carolyn J, Alavi Naini, Fatemeh, Bajić, Aleksandar, Craigen, Evelyn, Richman, Ronald, Heman-Ackah, Sabrina M, Wood, Matthew J A, Rousseaux, Maxime W C, Zoghbi, Huda Y
Published in The Journal of neuroscience (08.01.2020)
Published in The Journal of neuroscience (08.01.2020)
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Journal Article
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway
Aleyasin, Hossein, Rousseaux, Maxime W.C, Marcogliese, Paul C, Hewitt, Sarah J, Irrcher, Isabella, Joselin, Alvin P, Parsanejad, Mohammad, Kim, Raymond H, Rizzu, Patrizia, Callaghan, Steve M, Slack, Ruth S, Mak, Tak W, Park, David S
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
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Journal Article
Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease
Qu, Dianbo, Rashidian, Juliet, Mount, Matthew P., Aleyasin, Hossein, Parsanejad, Mohammad, Lira, Arman, Haque, Emdadul, Zhang, Yi, Callaghan, Steve, Daigle, Mireille, Rousseaux, Maxime W.C., Slack, Ruth S., Albert, Paul R., Vincent, Inez, Woulfe, John M., Park, David S.
Published in Neuron (Cambridge, Mass.) (05.07.2007)
Published in Neuron (Cambridge, Mass.) (05.07.2007)
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Journal Article
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease
Rousseaux, Maxime W. C, Marcogliese, Paul C, Qu, Dianbo, Hewitt, Sarah J, Seang, Sarah, Kim, Raymond H, Slack, Ruth S, Schlossmacher, Michael G, Lagace, Diane C, Mak, Tak W, Park, David S
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2012)
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Journal Article
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death
Haque, M. Emdadul, Woulfe, John M, Slack, Ruth S, Rousseaux, Maxime W.C, Park, David S, Qu, Dianbo, Zhang, Yi, Huang, En, Venderova, Katerina
Published in Nature cell biology (01.06.2010)
Published in Nature cell biology (01.06.2010)
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Journal Article
Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage
Aleyasin, Hossein, Rousseaux, Maxime W.C, Phillips, Maryam, Kim, Raymond H, Bland, Ross J, Callaghan, Steve, Slack, Ruth S, During, Matthew J, Mak, Tak W, Park, David S
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
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Journal Article
Regulation of the VHL/HIF-1 pathway by DJ-1
Parsanejad, Mohammad, Zhang, Yi, Qu, Dianbo, Irrcher, Isabella, Rousseaux, Maxime W C, Aleyasin, Hossein, Kamkar, Fatemeh, Callaghan, Steve, Slack, Ruth S, Mak, Tak W, Lee, Stephen, Figeys, Daniel, Park, David S
Published in The Journal of neuroscience (04.06.2014)
Published in The Journal of neuroscience (04.06.2014)
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Journal Article
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage
Zhang, Yi, Parsanejad, Mohammad, Huang, En, Qu, Dianbo, Aleyasin, Hossein, Rousseaux, Maxime W.C, Gonzalez, Yasmilde Rodriguez, Cregan, Sean P, Slack, Ruth S, Park, David S
Published in Journal of neurochemistry (2010)
Published in Journal of neurochemistry (2010)
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Journal Article
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism
Rousseaux, Maxime W.C., Tschumperlin, Tyler, Lu, Hsiang-Chih, Lackey, Elizabeth P., Bondar, Vitaliy V., Wan, Ying-Wooi, Tan, Qiumin, Adamski, Carolyn J., Friedrich, Jillian, Twaroski, Kirk, Chen, Weili, Tolar, Jakub, Henzler, Christine, Sharma, Ajay, Bajić, Aleksandar, Lin, Tao, Duvick, Lisa, Liu, Zhandong, Sillitoe, Roy V., Zoghbi, Huda Y., Orr, Harry T.
Published in Neuron (Cambridge, Mass.) (21.03.2018)
Published in Neuron (Cambridge, Mass.) (21.03.2018)
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