Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development
Page, Natalie, Wappett, Mark, O’Dowd, Colin R., O’Rourke, Martin, Gavory, Gerald, Zhang, Lixin, Rountree, J. S. Shane, Jordan, Linda, Barker, Oliver, Gibson, Hayley, Boyd, Caroline, Feutren-Burton, Stephanie, McLean, Estelle, Trevitt, Graham, Harrison, Timothy
Published in Scientific reports (20.09.2022)
Published in Scientific reports (20.09.2022)
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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Jurisic, Anamarija, Sung, Pei‐Ju, Wappett, Mark, Daubriac, Julien, Lobb, Ian T., Kung, Wei‐Wei, Crawford, Nyree, Page, Natalie, Cassidy, Eamon, Feutren‐Burton, Stephanie, Rountree, J. S. Shane, Helm, Matthew D., O'Dowd, Colin R., Kennedy, Richard D., Gavory, Gerald, Cranston, Aaron N., Longley, Daniel B., Jacq, Xavier, Harrison, Timothy
Published in Clinical and translational medicine (01.04.2024)
Published in Clinical and translational medicine (01.04.2024)
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Synthesis and Biological Characterisation of Novel N-Alkyl-Deoxynojirimycin α-Glucosidase Inhibitors
Rawlings, Amy J, Lomas, Hannah, Pilling, Adam W, Lee, Marvin J.-R, Alonzi, Dominic S, Rountree, J.S. Shane, Jenkinson, Sarah F, Fleet, George W.J, Dwek, Raymond A, Jones, John H, Butters, Terry D
Published in Chembiochem : a European journal of chemical biology (17.04.2009)
Published in Chembiochem : a European journal of chemical biology (17.04.2009)
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Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease
Rountree, J. S. Shane, Butters, Terry D., Wormald, Mark R., Boomkamp, Stephanie D., Dwek, Raymond A., Asano, Naoki, Ikeda, Kyoko, Evinson, Emma L., Nash, Robert J., Fleet, George W. J.
Published in ChemMedChem (16.03.2009)
Published in ChemMedChem (16.03.2009)
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Abstract LB-049: Targeting the ubiquitin-proteasome system by small molecule inhibition of the DUBome
Harrison, Tim, Jacq, Xavier, O'Dowd, Colin, Gavory, Gerald, Barker, Oliver, Bell, Christina, Burkamp, Frank, Burton, Stephanie, Cassidy, Eamon, Helm, Matthew, Hewitt, Peter, Page, Natalie, Rountree, Shane, Rozycka, Ewelina, Shepherd, Steven, Whitehead, Steven, Wappett, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors
O’Dowd, Colin R, Helm, Matthew D, Rountree, J. S. Shane, Flasz, Jakub T, Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R, Jordan, Linda, Barker, Oliver, Hughes, Caroline, Rozycka, Ewelina, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Feutren-Burton, Stephanie, Dvorkin, Scarlett, Gavory, Gerald, Harrison, Timothy
Published in ACS medicinal chemistry letters (08.03.2018)
Published in ACS medicinal chemistry letters (08.03.2018)
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Abstract LB-159: A novel, potent and selective inhibitor of Wee1 with robust antitumor activity in various cancer xenograph models
Gavory, Gerald, O’Dowd, Colin, Burkamp, Frank, Rountree, Shane, Rozycka, Ewelina, Boyd, Caroline, Gorges, Beronia, Burton, Stephanie, Wilkinson, Andy, Shepherd, Steven, Janssen, Dominic, McFarland, Mary, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract LB-319: Development and characterization of ADC999 : A novel, potent orally available Wee1 inhibitor with robust antitumor efficacy in vivo
Gavory, Gerald, O'Dowd, Colin, Rozycka, Ewelina, Boyd, Caroline, Gorges, Beronia, McLean, Estelle, Daubriac, Julien, Rountree, Shane, Shepherd, Steven, Burton, Stephanie, McFarland, Mary, Treder, Adam, Wilkinson, Andy, Burkamp, Frank, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 1935: Accessing the cancer DUBome with UbiPlex: A bespoke drug discovery platform for deubiquitinase enzymes
Gavory, Gerald, O'Dowd, Colin, Barker, Oliver, Bell, Christina, Burkamp, Frank, Burton, Stephanie, Cassidy, Eamon, Costa, Joana, Dossang, Anthony, Helm, Matt, Henderson, Ashling, Hewitt, Peter, Hughes, Caroline, McFarland, Mary, Miel, Hugues, Page, Natalie, Proctor, Lauren, Rountree, Shane, Rozycka, Ewelina, Shepherd, Steven, Treder, Adam, Wappett, Mark, Whitehead, Steven, Harrison, Tim
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract B17: Development of novel, potent orally available Wee1 inhibitors with robust antitumor efficacy in vivo
Gavory, Gerald, O'Dowd, Colin, Rozycka, Ewelina, Boyd, Caroline, Gorges, Beronia, McLean, Estelle, Rountree, Shane, Sheperd, Steven, Burton, Stephanie, McFarland, Mary, Janssen, Dominic, Treder, Adam, Wilkinson, Andy, Burkamp, Frank, Harrison, Tim
Published in Molecular cancer research (01.04.2017)
Published in Molecular cancer research (01.04.2017)
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Abstract LB022: A novel first-in-class USP19 inhibitor for the treatment of cancer-induced muscle atrophy
Page, Natalie, Karthikaisamy, Vignesh, O'Hara, Darren, Cranston, Aaron N., O'Dowd, Colin R., Jacq, Xavier, Wilkinson, Richard, Burton, Stephanie, Gibson, Hayley, Costa, Joana, Longley, Daniel, Helm, Matthew, McGivern, Chris, Shepherd, Steven, Bell, Christina, Hewitt, Peter, McFarland, Mary, Miel, Hugues, Whitehead, Steven, Proctor, Lauren, Rountree, Shane J., Wappett, Mark, Diaz, Mauricio Berriel, Herzig, Stephan, Harrison, Timothy
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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유비퀴틴 특이적 프로테아제 7의 억제제로서 피페리딘 유도체
JORDAN LINDA, WERTZ INGRID, O'DOWD COLIN, LEE WENDY, BROCCATELLI FABIO, HUGUES MIEL, HELM MATTHEW, ROUNTREE SHANE, HEWITT PETER, CRAWFORD JAMES JOHN, BURKAMP FRANK, GAZZARD LEWIS, HARRISON TIM
Year of Publication 19.06.2019
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Year of Publication 19.06.2019
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2-Acetamido- N -benzyl-1,4-imino-1,2,4-trideoxy- L -ribitol
Harding, Christopher C., Watkin, David J., Rountree, J. S. Shane, Butters, Terry D., Wormald, Mark R., Dwek, Raymond A., Fleet, George W. J.
Published in Acta crystallographica. Section E, Structure reports online (01.04.2005)
Published in Acta crystallographica. Section E, Structure reports online (01.04.2005)
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PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
CRAWFORD, James John, HUGUES, Miel, O'DOWD, Colin, ROUNTREE, Shane, BURKAMP, Frank, HARRISON, Tim, HEWITT, Peter, GAZZARD, Lewis, HELM, Matthew, BROCCATELLI, Fabio, WERTZ, Ingrid, LEE, Wendy, JORDAN, Linda
Year of Publication 13.07.2022
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Year of Publication 13.07.2022
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Pireridinderivater som inhibitorer af ubiquitin-specifik protease 7
CRAWFORD, James John, HUGUES, Miel, O'DOWD, Colin, ROUNTREE, Shane, BURKAMP, Frank, HARRISON, Tim, HEWITT, Peter, GAZZARD, Lewis, HELM, Matthew, BROCCATELLI, Fabio, WERTZ, Ingrid, LEE, Wendy, JORDAN, Linda
Year of Publication 11.07.2022
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Year of Publication 11.07.2022
Patent
PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
CRAWFORD, James John, HUGUES, Miel, O'DOWD, Colin, ROUNTREE, Shane, BURKAMP, Frank, HARRISON, Tim, HEWITT, Peter, GAZZARD, Lewis, HELM, Matthew, BROCCATELLI, Fabio, WERTZ, Ingrid, LEE, Wendy, JORDAN, Linda
Year of Publication 06.04.2022
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Year of Publication 06.04.2022
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Piperidine derivatives as inhibitors of ubiquitin specific protease 7
Hewitt, Peter, Broccatelli, Fabio, Gazzard, Lewis, Burkamp, Frank, Helm, Matthew, Jordan, Linda, Rountree, Shane, Lee, Wendy, O'Dowd, Colin, Crawford, James John, Hugues, Miel, Harrison, Tim, Wertz, Ingrid
Year of Publication 14.10.2021
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Year of Publication 14.10.2021
Patent