Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer
Gomez‐Roca, Carlos, Even, Caroline, Le Tourneau, Christophe, Basté, Neus, Delord, Jean‐Pierre, Sarini, Jerome, Vergez, Sebastien, Temam, Stephane, Hoffmann, Caroline, Rochaix, Philippe, Borcoman, Edith, Gavillet, Bruno, Rouits, Elisabeth, Ménétrey, Annick, Brichory, Franck, Purcea, Daniela, Vuagniaux, Gregoire, Zanna, Claudio
Published in Clinical and translational science (01.01.2022)
Published in Clinical and translational science (01.01.2022)
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Tumor Distribution by Quantitative Mass Spectrometry Imaging of the Inhibitor of Apoptosis Protein Antagonist Xevinapant in Patients with Resectable Squamous Cell Carcinoma of the Head and Neck (EudraCT Number: 2014-004655-31)
Menetrey, Annick, Legouffe, Raphael, Haouala, Amina, Bonnel, David, Rouits, Elisabeth, Bosq, Jacques, Stauber, Jonathan
Published in Analytical chemistry (Washington) (13.09.2022)
Published in Analytical chemistry (Washington) (13.09.2022)
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Leveraging the mechanism of action (MOA) of xevinapant, an IAP inhibitor, for phase 3 dosing (RP3D) strategies in combination with radiation (RT) and chemoradiotherapy (CRT) in patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN)
Vugmeyster, Yulia, Ravula, Abhigyan, Rouits, Elisabeth, Ferretti, Roberta, Glaeser, Kathrin, Esdar, Christina, Schröder, Andreas, Koenig, Andre, Venkatakrishnan, Karthik, Goteti, Kosalaram
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Model‐Informed Selection of the Recommended Phase III Dose of the Inhibitor of Apoptosis Protein Inhibitor, Xevinapant, in Combination with Cisplatin and Concurrent Radiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Vugmeyster, Yulia, Ravula, Abhigyan, Rouits, Elisabeth, Diderichsen, Paul Matthias, Kleijn, Huub Jan, Koenig, Andre, Wang, XiaoZhe, Schroeder, Andreas, Goteti, Kosalaram, Venkatakrishnan, Karthik
Published in Clinical pharmacology and therapeutics (01.01.2024)
Published in Clinical pharmacology and therapeutics (01.01.2024)
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Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study
Sun, Xu-Shan, Tao, Yungan, Le Tourneau, Christophe, Pointreau, Yoann, Sire, Christian, Kaminsky, Marie-Christine, Coutte, Alexandre, Alfonsi, Marc, Boisselier, Pierre, Martin, Laurent, Miroir, Jessica, Ramee, Jean-Francois, Delord, Jean-Pierre, Clatot, Florian, Rolland, Frederic, Villa, Julie, Magne, Nicolas, Elicin, Olgun, Gherga, Elisabeta, Nguyen, France, Lafond, Cedrick, Bera, Guillaume, Calugaru, Valentin, Geoffrois, Lionnel, Chauffert, Bruno, Zubel, Angela, Zanna, Claudio, Brienza, Silvano, Crompton, Philippa, Rouits, Elisabeth, Gollmer, Kathrin, Szyldergemajn, Sergio, Bourhis, Jean
Published in The lancet oncology (01.09.2020)
Published in The lancet oncology (01.09.2020)
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Journal Article
Relevance of Different UGT1A1 Polymorphisms in Irinotecan-Induced Toxicity
Rouits, Elisabeth, Boisdron-Celle, Michèle, Dumont, Agnès, Guérin, Olivier, Morel, Alain, Gamelin, Erick
Published in Clinical cancer research (01.08.2004)
Published in Clinical cancer research (01.08.2004)
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Journal Article
Phase I Trial of Debio 1143, an Antagonist of Inhibitor of Apoptosis Proteins, Combined with Cisplatin Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Le Tourneau, Christophe, Tao, Yungan, Gomez-Roca, Carlos, Cristina, Valerie, Borcoman, Edith, Deutsch, Eric, Bahleda, Rastislav, Calugaru, Valentin, Modesto, Anouchka, Rouits, Elisabeth, Gollmer, Kathrin, Vuagniaux, Gregoire, Crompton, Philippa, Zanna, Claudio, Szyldergemajn, Sergio, Delord, Jean-Pierre, Bourhis, Jean
Published in Clinical cancer research (15.12.2020)
Published in Clinical cancer research (15.12.2020)
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Journal Article
Safety and Efficacy of CD37-Targeting Naratuximab Emtansine PLUS Rituximab in Diffuse Large B-Cell Lymphoma and Other NON-Hodgkin'S B-Cell Lymphomas - a Phase 2 Study
Levy, Moshe Y., Jagadeesh, Deepa, Grudeva-Popova, Zhanet, Trněný, Marek, Jurczak, Wojciech, Pylypenko, Halyna, André, Marc, Dwivedy Nasta, Sunita, Rechavi-Robinson, Dalit, Toffanin, Sara, Micallef, Sandrine, Attinger, Antoine, Rouits, Elisabeth, Roubaudi-Fraschini, Marie-Claude, Orfanos, Panos, Dymkowska, Mariola, Nauwelaerts, Heidi, Woei-a-Jin, Sherida
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study
Hurwitz, Herbert I., Smith, David C., Pitot, Henry C., Brill, Jeffrey M., Chugh, Rashmi, Rouits, Elisabeth, Rubin, Joseph, Strickler, John, Vuagniaux, Gregoire, Sorensen, J. Mel, Zanna, Claudio
Published in Cancer chemotherapy and pharmacology (01.04.2015)
Published in Cancer chemotherapy and pharmacology (01.04.2015)
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Journal Article
Abstract CT140: A phase 1 study of the IAP inhibitor xevinapant (Debio 1143) to evaluate food effect and drug-drug interactions with a proton pump inhibitor in healthy volunteers
Nicolas-Métral, Valérie, Rouits, Elisabeth, Riff, Camille, Spaggiari, Dany, Wiedemann, Norbert, Colin, Pierre, Harrison-Moench, Eleanor, Crabbé, Rafael, Nauwelaerts, Heidi, Schroeder, Andreas, Haefliger, Carolina, Vugmeyster, Yulia
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article
Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: A molecular and clinical study of 75 patients
ROUITS, Elisabeth, BOISDRON-CELLE, Michèle, DUMONT, Agnès, GUERIN, Olivier, MOREL, Alain, GAMELIN, Erick
Published in Clinical cancer research (01.08.2004)
Published in Clinical cancer research (01.08.2004)
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Journal Article
Abstract 5424: Selection of RP3D of xevinapant in combination with CRT in patients with LA SCCHN
Vugmeyster, Yulia, Ravula, Abhigyan, Rouits, Elisabeth, Diderichsen, Paul M., Kleijn, Huub J., Goteti, Kosalaram, Schroeder, Andreas, Venkatakrishnan, Karthik
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 5001: Open-label, non-randomized, exploratory pre-operative window-of-opportunity trial to investigate the pharmacokinetics and pharmacodynamics of the smac mimetic Debio 1143 in patients with resectable squamous cell carcinoma of the head and neck
Gomez-Roca, Carlos, Even, Caroline, Tourneau, Christophe Le, Rotllan, Neus Basté, Delord, Jean-Pierre, Sarini, Jerome, Vergez, Sebastien, Teman, Stephane, Hoffmann, Caroline, Rochaix, Philippe, Gavillet, Bruno, Rouits, Elisabeth, Brichory, Franck, Rechavi-Robinson, Dalit, Bize, Vincent, Rizzo, Sebastien Del, Purcea, Daniela, Brienza, Silvano, Zanna, Claudio, Vuagniaux, Gregoire, Szyldergemajn, Sergio
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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A dose-finding study of the SMAC mimetic Debio 1143 when given in combination with avelumab to patients with advanced solid malignancies
Juergens, Rosalyn A., Chu, Quincy S., Renouf, Daniel John, Laurie, Scott Andrew, Purcea, Daniela, McWhirter, Elaine, Arndt, Diane, Gelmon, Karen A., Hilton, John, Gavillet, Bruno, Ellis, Peter Michael, Sawyer, Michael B., Kollmannsberger, Christian K., Andrews Wright, Natalie, Rouits, Elisabeth, Brichory, Frank, Vuagniaux, Gregoire, Szyldergemajn, Sergio A., Goss, Glenwood
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
Phase I dose-escalation study with extended daily administration of Debio1143, an oral inhibitor of apoptosis protein inhibitor, in patients with solid tumors
Pitot, Henry C., Hurwitz, Herbert, Zanna, Claudio, Brill, Jeffrey Mark, Vuagniaux, Gregoire, Rouits, Elisabeth, Sorensen, J. Mel, Smith, David C.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Abstract CT202: Xevinapant plus avelumab in patients (pts) with advanced or metastatic non-small cell lung cancer (NSCLC): Phase 1b dose-expansion results and exploratory biomarker analyses
Chu, Quincy, Ciuleanu, Tudor, Ramlau, Rodryg, Renouf, Daniel, Juergens, Rosalyn, Kalinka, Ewa, Sawrycki, Piotr, Bramson, Jonathan, Nelson, Brad, Crabbé, Rafael, Sahlender, Daniela A., Crompton, Philippa, Rouits, Elisabeth, Spaggiari, Dany, Brichory, Franck, Piggott, Luke, Schenker, Mike, Goss, Glenwood
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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589 Xevinapant plus nivolumab in patients with advanced solid tumors who progressed on prior anti–PD-1/PD-L1 treatment: results of a dose-optimization, exploratory phase 1b/2 trial
Emiliano Calvo Aller, Hanna, Glenn, Maria Vieito Villar, Even, Caroline, Moreno, Victor, Kim, Chul, Gulati, Shuchi, Morgensztern, Daniel, Acuna-Villaorduna, Ana, Cassier, Philippe, Jones, Dennie, Bouisset, Florilene, Sahlender, Daniela, Rouits, Elisabeth, Spaggiari, Dany, Damstrup, Lars, Gomez-Roca, Carlos-Alberto
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Clinical pharmacokinetic (PK)/pharmacodynamic (PD) model for Debio 1143, a novel antagonist of IAPs in cancer treatment
Rouits, Elisabeth, Gisleskog, Per Olsson, Gavillet, Bruno, Menetrey, Annick, Sorensen, Mel, Zanna, Claudio, Vuagniaux, Gregoire, Nicolas-Metral, Valerie
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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