Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Bäurle, Stefan, Nagel, Jens, Peters, Olaf, Bräuer, Nico, ter Laak, Antonius, Preusse, Cornelia, Rottmann, Antje, Heldmann, Dieter, Bothe, Ulrich, Blume, Thorsten, Zorn, Ludwig, Walter, Daryl, Zollner, Thomas M, Steinmeyer, Andreas, Langer, Gernot
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies
Möller, Carsten, Bone, Wilhelm, Cleve, Arwed, Klar, Ulrich, Rotgeri, Andrea, Rottmann, Antje, Schultze‐Mosgau, Marcus‐Hillert, Wagenfeld, Andrea, Schwede, Wolfgang
Published in ChemMedChem (06.11.2018)
Published in ChemMedChem (06.11.2018)
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Journal Article
Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis
Hilpert, Jan, Groettrup-Wolfers, Esther, Kosturski, Hristiyan, Bennett, Laura, Barnes, Catriona L. K., Gude, Kerstin, Gashaw, Isabella, Reif, Stefanie, Steger-Hartmann, Thomas, Scheerans, Christian, Solms, Alexander, Rottmann, Antje, Mao, Guangping, Chapron, Charles
Published in Drugs in R&D (01.09.2023)
Published in Drugs in R&D (01.09.2023)
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Journal Article
The Starch-Related R1 Protein is an α-Glucan, Water Dikinase
Ritte, Gerhard, Lloyd, James R., Eckermann, Nora, Rottmann, Antje, Kossmann, Jens, Steup, Martin
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2002)
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Journal Article
Metabolism and Disposition of Vatalanib (PTK787/ZK-222584) in Cancer Patients
JOST, Lorenz M, GSCHWIND, Hans-Peter, MASSON, Eric, LAURENT, Dirk, JALAVA, Tarja, YONGYU WANG, GUENTHER, Clemens, SOUPPART, Claire, ROTTMANN, Antje, DENNER, Karsten, WALDMEIER, Felix, GROSS, Gerhard
Published in Drug metabolism and disposition (01.11.2006)
Published in Drug metabolism and disposition (01.11.2006)
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Journal Article
Pharmacokinetics, Safety, and Tolerability of the Novel Tetrameric, High-Relaxivity, Macrocyclic Gadolinium-Based Contrast Agent Gadoquatrane in Healthy Adults
Hofmann, Birte Maria, Riecke, Kai, Klein, Stefan, Berse, Matthias, Rottmann, Antje, Sutter, Gabriele, Ebert, Wolfgang
Published in Investigative radiology (01.02.2024)
Published in Investigative radiology (01.02.2024)
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Journal Article
Preclinical and Clinical Pharmacokinetics and Bioavailability in Healthy Volunteers of a Novel Formulation of the Selective P2X3 Receptor Antagonist Eliapixant
Francke, Klaus, Chattopadhyay, Niladri, Klein, Stefan, Rottmann, Antje, Krickau, Dennis, van de Wetering, Jeroen, Friedrich, Christian
Published in European journal of drug metabolism and pharmacokinetics (2023)
Published in European journal of drug metabolism and pharmacokinetics (2023)
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Journal Article
Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688
Battista, Christina, Shoda, Lisl K M, Watkins, Paul B, Groettrup-Wolfers, Esther, Rottmann, Antje, Raschke, Marian, Generaux, Grant T
Published in Clinical pharmacology and therapeutics (01.11.2023)
Published in Clinical pharmacology and therapeutics (01.11.2023)
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Journal Article
Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview
Schultze-Mosgau, Marcus-Hillert, Ploeger, Bart A., Frei, Matthias, Höchel, Joachim, Rottmann, Antje
Published in Clinical pharmacokinetics (01.01.2022)
Published in Clinical pharmacokinetics (01.01.2022)
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Journal Article
Novel aldo-keto reductase 1C3 inhibitor affects androgen metabolism but not ovarian function in healthy women: a phase 1 study
Gashaw, Isabella, Reif, Stefanie, Wiesinger, Herbert, Kaiser, Andreas, Zollmann, Frank S, Scheerans, Christian, Grevel, Joachim, Piraino, Paolo, Seidel, Henrik, Peters, Michaele, Rottmann, Antje, Rohde, Beate, Arlt, Wiebke, Hilpert, Jan
Published in European journal of endocrinology (10.07.2023)
Published in European journal of endocrinology (10.07.2023)
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Journal Article
The Effects of Weak and Strong CYP3A Induction by Rifampicin on the Pharmacokinetics of Five Progestins and Ethinylestradiol Compared to Midazolam
Wiesinger, Herbert, Klein, Stefan, Rottmann, Antje, Nowotny, Bettina, Riecke, Kai, Gashaw, Isabella, Brudny‐Klöppel, Margarete, Fricke, Robert, Höchel, Joachim, Friedrich, Christian
Published in Clinical pharmacology and therapeutics (01.10.2020)
Published in Clinical pharmacology and therapeutics (01.10.2020)
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Journal Article
Characterization of the Pharmacokinetics of Vilaprisan: Bioavailability, Excretion, Biotransformation, and Drug–Drug Interaction Potential
Schultze-Mosgau, Marcus-Hillert, Höchel, Joachim, Prien, Olaf, Zimmermann, Torsten, Brooks, Ashley, Bush, Jim, Rottmann, Antje
Published in Clinical pharmacokinetics (01.08.2018)
Published in Clinical pharmacokinetics (01.08.2018)
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Journal Article
A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy
Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette
Published in Bioconjugate chemistry (15.06.2022)
Published in Bioconjugate chemistry (15.06.2022)
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Journal Article
Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate
Berger, Markus, May, Ekkehard, Rehwinkel, Hartmut, Schäcke, Heike, Neuhaus, Roland, Rottmann, Antje, Zollner, Thomas M., Jaroch, Stefan
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Mass Balance and Metabolic Pathways of Eliapixant, a P2X3 Receptor Antagonist, in Healthy Male Volunteers
Reif, Stefanie, Schultze-Mosgau, Marcus-Hillert, Engelen, Anna, Piel, Isabel, Denner, Karsten, Roffel, Ad, Tiessen, Renger, Klein, Stefan, Francke, Klaus, Rottmann, Antje
Published in European journal of drug metabolism and pharmacokinetics (2024)
Published in European journal of drug metabolism and pharmacokinetics (2024)
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Journal Article
CYP3A4‐mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1‐mediated effects on bilirubin glucuronidation in humans
Chattopadhyay, Niladri, Kanacher, Tobias, Casjens, Manuela, Frechen, Sebastian, Ligges, Sandra, Zimmermann, Torsten, Rottmann, Antje, Ploeger, Bart, Höchel, Joachim, Schultze‐Mosgau, Marcus‐Hillert
Published in British journal of clinical pharmacology (01.12.2018)
Published in British journal of clinical pharmacology (01.12.2018)
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Journal Article
Abstract 2907: Identification and optimization of a novel NAMPT inhibitor-based ADC payload class for cancer therapy
Böhnke, Niels, Berger, Markus, Griebenow, Nils, Giese, Anja, Günther, Judith, Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Beier, Rudolf, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Rottmann, Antje, Erkelenz, Michael, Barak, Naomi, Bömer, Ulf, Mumber, Dominik, Kreft, Bertolt, Linden, Lars, Nising, Carl Friedrich, Weinmann, Hilmar
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Front Cover: Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies (ChemMedChem 21/2018)
Möller, Carsten, Bone, Wilhelm, Cleve, Arwed, Klar, Ulrich, Rotgeri, Andrea, Rottmann, Antje, Schultze‐Mosgau, Marcus‐Hillert, Wagenfeld, Andrea, Schwede, Wolfgang
Published in ChemMedChem (06.11.2018)
Published in ChemMedChem (06.11.2018)
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Journal Article
3-(5-메틸-1,3-티아졸-2-일)-N-{(1R)-1-[2-(트리플루오로-메틸)피리미딘-5-일]에틸}벤즈아미드의 유사체
ROTTMANN ANTJE, ROTGERI ANDREA, HERBERT SIMON ANTHONY, POOK ELISABETH, FISCHER OLIVER MARTIN, THEDE KAI, GANZER URSULA
Year of Publication 08.03.2022
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Year of Publication 08.03.2022
Patent
13--2- 13-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
GODINHO COELHO ANNE MARIE, ROTGERI ANDREA, ROTTMANN ANTJE, NAGEL JENS, DAVENPORT ADAM JAMES, NEAGOE IOANA, FISCHER OLIVER MARTIN, KLAR JUERGEN, BRAEUER NICO
Year of Publication 03.07.2023
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Year of Publication 03.07.2023
Patent