TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
Zang, Ruochen, Gomez Castro, Maria Florencia, McCune, Broc T, Zeng, Qiru, Rothlauf, Paul W, Sonnek, Naomi M, Liu, Zhuoming, Brulois, Kevin F, Wang, Xin, Greenberg, Harry B, Diamond, Michael S, Ciorba, Matthew A, Whelan, Sean P J, Ding, Siyuan
Published in Science Immunology (13.05.2020)
Published in Science Immunology (13.05.2020)
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Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Kang, Yuan-Lin, Chou, Yi-ying, Rothlauf, Paul W., Liu, Zhuoming, Soh, Timothy K., Cureton, David, Case, James Brett, Chen, Rita E., Diamond, Michael S., Whelan, Sean P. J., Kirchhausen, Tom
Published in Proceedings of the National Academy of Sciences - PNAS (25.08.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (25.08.2020)
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Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2
Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Liu, Zhuoming, Zhao, Haiyan, Kim, Arthur S., Bloyet, Louis-Marie, Zeng, Qiru, Tahan, Stephen, Droit, Lindsay, Ilagan, Ma. Xenia G., Tartell, Michael A., Amarasinghe, Gaya, Henderson, Jeffrey P., Miersch, Shane, Ustav, Mart, Sidhu, Sachdev, Virgin, Herbert W., Wang, David, Ding, Siyuan, Corti, Davide, Theel, Elitza S., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.
Published in Cell Host & Microbe (09.09.2020)
Published in Cell Host & Microbe (09.09.2020)
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Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
Zang, Ruochen, Case, James Brett, Yutuc, Eylan, Ma, Xiucui, Shen, Sheng, Castro, Maria Florencia Gomez, Liu, Zhuoming, Zeng, Qiru, Zhao, Haiyan, Son, Juhee, Rothlauf, Paul W., Kreutzberger, Alex J. B., Hou, Gaopeng, Zhang, Hu, Bose, Sayantan, Wang, Xin, Vahey, Michael D., Mani, Kartik, Griffiths, William J., Kirchhausen, Tom, Fremont, Daved H., Guo, Haitao, Diwan, Abhinav, Wang, Yuqin, Diamond, Michael S., Whelan, Sean P. J., Ding, Siyuan
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2020)
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Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice
Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Kafai, Natasha M., Fox, Julie M., Smith, Brittany K., Shrihari, Swathi, McCune, Broc T., Harvey, Ian B., Keeler, Shamus P., Bloyet, Louis-Marie, Zhao, Haiyan, Ma, Meisheng, Adams, Lucas J., Winkler, Emma S., Holtzman, Michael J., Fremont, Daved H., Whelan, Sean P.J., Diamond, Michael S.
Published in Cell Host & Microbe (09.09.2020)
Published in Cell Host & Microbe (09.09.2020)
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Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7
Doyle, Catherine A., Busey, Gregory W., Iobst, Wesley H., Kiessling, Volker, Renken, Chloe, Doppalapudi, Hansa, Stremska, Marta E., Manjegowda, Mohan C., Arish, Mohd, Wang, Weiming, Naphade, Shardul, Kennedy, Joel, Bloyet, Louis-Marie, Thompson, Cassandra E., Rothlauf, Paul W., Stipes, Eric J., Whelan, Sean P. J., Tamm, Lukas K., Kreutzberger, Alex J. B., Sun, Jie, Desai, Bimal N.
Published in Nature communications (01.10.2024)
Published in Nature communications (01.10.2024)
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N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
McCallum, Matthew, De Marco, Anna, Lempp, Florian A., Tortorici, M. Alejandra, Pinto, Dora, Walls, Alexandra C., Beltramello, Martina, Chen, Alex, Liu, Zhuoming, Zatta, Fabrizia, Zepeda, Samantha, di Iulio, Julia, Bowen, John E., Montiel-Ruiz, Martin, Zhou, Jiayi, Rosen, Laura E., Bianchi, Siro, Guarino, Barbara, Fregni, Chiara Silacci, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Rothlauf, Paul W., Bloyet, Louis-Marie, Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Riva, Agostino, Snell, Gyorgy, Telenti, Amalio, Whelan, Sean P.J., Virgin, Herbert W., Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David
Published in Cell (29.04.2021)
Published in Cell (29.04.2021)
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A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex
Chen, Han, Lye, Ming F, Gorgulla, Christoph, Ficarro, Scott B, Cuny, Gregory D, Scott, David A, Wu, Fan, Rothlauf, Paul W, Wang, Xiaoou, Fernandez, Rosio, Pesola, Jean M, Draga, Sorin, Marto, Jarrod A, Hogle, James M, Arthanari, Haribabu, Coen, Donald M
Published in PLoS pathogens (17.11.2023)
Published in PLoS pathogens (17.11.2023)
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Noninvasive Immuno-PET Imaging of CD8 + T Cell Behavior in Influenza A Virus-Infected Mice
Rothlauf, Paul W, Li, Zeyang, Pishesha, Novalia, Xie, Yushu Joy, Woodham, Andrew W, Bousbaine, Djenet, Kolifrath, Stephen C, Verschoor, Vincent L, Ploegh, Hidde L
Published in Frontiers in immunology (03.11.2021)
Published in Frontiers in immunology (03.11.2021)
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Saliva enhances infection of gingival fibroblasts by herpes simplex virus 1
Zuo, Yi, Whitbeck, J Charles, Haila, Gabriel J, Hakim, Abraham A, Rothlauf, Paul W, Eisenberg, Roselyn J, Cohen, Gary H, Krummenacher, Claude
Published in PloS one (03.10.2019)
Published in PloS one (03.10.2019)
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Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Zost, Seth J., Gilchuk, Pavlo, Chen, Rita E., Case, James Brett, Reidy, Joseph X., Trivette, Andrew, Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Chen, Elaine C., Binshtein, Elad, Shrihari, Swathi, Ostrowski, Mario, Chu, Helen Y., Didier, Jonathan E., MacRenaris, Keith W., Jones, Taylor, Day, Samuel, Myers, Luke, Eun-Hyung Lee, F., Nguyen, Doan C., Sanz, Ignacio, Martinez, David R., Rothlauf, Paul W., Bloyet, Louis-Marie, Whelan, Sean P. J., Baric, Ralph S., Thackray, Larissa B., Diamond, Michael S., Carnahan, Robert H., Crowe, James E.
Published in Nature medicine (01.09.2020)
Published in Nature medicine (01.09.2020)
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BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein
Manangeeswaran, Mohanraj, Ireland, Derek D. C., Thacker, Seth G., Lee, Ha-Na, Kelley-Baker, Logan, Lewkowicz, Aaron P., Rothlauf, Paul W., Cornejo Pontelli, Marjorie, Bloyet, Louis-Marie, Eckhaus, Michael A., Mendoza, Mirian I., Whelan, Sean, Verthelyi, Daniela
Published in Frontiers in immunology (28.07.2022)
Published in Frontiers in immunology (28.07.2022)
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
Puray-Chavez, Maritza, LaPak, Kyle M., Schrank, Travis P., Elliott, Jennifer L., Bhatt, Dhaval P., Agajanian, Megan J., Jasuja, Ria, Lawson, Dana Q., Davis, Keanu, Rothlauf, Paul W., Liu, Zhuoming, Jo, Heejoon, Lee, Nakyung, Tenneti, Kasyap, Eschbach, Jenna E., Shema Mugisha, Christian, Cousins, Emily M., Cloer, Erica W., Vuong, Hung R., VanBlargan, Laura A., Bailey, Adam L., Gilchuk, Pavlo, Crowe, James E., Diamond, Michael S., Hayes, D. Neil, Whelan, Sean P.J., Horani, Amjad, Brody, Steven L., Goldfarb, Dennis, Major, M. Ben, Kutluay, Sebla B.
Published in Cell reports (Cambridge) (13.07.2021)
Published in Cell reports (Cambridge) (13.07.2021)
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Detection of Bourbon Virus-Specific Serum Neutralizing Antibodies in Human Serum in Missouri, USA
Bamunuarachchi, Gayan, Harastani, Houda, Rothlauf, Paul W, Dai, Ya-Nan, Ellebedy, Ali, Fremont, Daved, Whelan, Sean P J, Wang, David, Boon, Adrianus C M
Published in mSphere (29.06.2022)
Published in mSphere (29.06.2022)
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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition
Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.
Published in Cell Host & Microbe (13.01.2021)
Published in Cell Host & Microbe (13.01.2021)
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Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
Liu, Zhuoming, VanBlargan, Laura A., Bloyet, Louis-Marie, Rothlauf, Paul W., Chen, Rita E., Stumpf, Spencer, Zhao, Haiyan, Errico, John M., Theel, Elitza S., Liebeskind, Mariel J., Alford, Brynn, Buchser, William J., Ellebedy, Ali H., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.
Published in Cell host & microbe (10.03.2021)
Published in Cell host & microbe (10.03.2021)
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JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis
Son, Juhee, Huang, Shimeng, Zeng, Qiru, Bricker, Traci L, Case, James Brett, Zhou, Jinzhu, Zang, Ruochen, Liu, Zhuoming, Chang, Xinjian, Darling, Tamarand L, Xu, Jian, Harastani, Houda H, Chen, Lu, Gomez Castro, Maria Florencia, Zhao, Yongxiang, Kohio, Hinissan P, Hou, Gaopeng, Fan, Baochao, Niu, Beibei, Guo, Rongli, Rothlauf, Paul W, Bailey, Adam L, Wang, Xin, Shi, Pei-Yong, Martinez, Elisabeth D, Brody, Steven L, Whelan, Sean P J, Diamond, Michael S, Boon, Adrianus C M, Li, Bin, Ding, Siyuan
Published in mBio (22.02.2022)
Published in mBio (22.02.2022)
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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Mahoney, Matthew, Damalanka, Vishnu C., Tartell, Michael A., Chung, Dong hee, Lourenço, André Luiz, Pwee, Dustin, Bridwell, Anne E. Mayer, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P., Klingler, Andrea M., Rothlauf, Paul W., Thompson, Cassandra E., Lee, Melody, Klampfer, Lidija, Stallings, Christina L., Rothenberg, Marc E., Pöhlmann, Stefan, Whelan, Sean P. J., O’Donoghue, Anthony J., Craik, Charles S., Janetka, James W.
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
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Herpes simplex virus glycoprotein D relocates nectin-1 from intercellular contacts
Bhargava, Arjun K, Rothlauf, Paul W, Krummenacher, Claude
Published in Virology (New York, N.Y.) (01.12.2016)
Published in Virology (New York, N.Y.) (01.12.2016)
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A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants
Pishesha, Novalia, Harmand, Thibault J., Rothlauf, Paul W., Praest, Patrique, Alexander, Ryan K., van den Doel, Renate, Liebeskind, Mariel J., Vakaki, Maria A., McCaul, Nicholas, Wijne, Charlotte, Verhaar, Elisha, Pinney, William, Heston, Hailey, Bloyet, Louis-Marie, Pontelli, Marjorie Cornejo, Ilagan, Ma. Xenia G., Lebbink, Robert Jan, Buchser, William J., Wiertz, Emmanuel J. H. J., Whelan, Sean P. J., Ploegh, Hidde L.
Published in Proceedings of the National Academy of Sciences - PNAS (02.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (02.11.2021)
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