Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors
Woodhead, Jeffrey L, Brock, William J, Roth, Sharin E, Shoaf, Susan E, Brouwer, Kim L R, Church, Rachel, Grammatopoulos, Tom N, Stiles, Linsey, Siler, Scott Q, Howell, Brett A, Mosedale, Merrie, Watkins, Paul B, Shoda, Lisl K M
Published in Toxicological sciences (01.01.2017)
Published in Toxicological sciences (01.01.2017)
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Clinical Pattern of Tolvaptan-Associated Liver Injury in Trial Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD): An Analysis of Pivotal Clinical Trials
Alpers, David H., Lewis, James H., Hunt, Christine M., Freston, James W., Torres, Vicente E., Li, Hui, Wang, Wenchyi, Hoke, Molly E., Roth, Sharin E., Westcott-Baker, Lucas, Estilo, Alvin
Published in American journal of kidney diseases (01.03.2023)
Published in American journal of kidney diseases (01.03.2023)
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Journal Article
Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease
Bezençon, Jacqueline, Beaudoin, James J, Ito, Katsuaki, Fu, Dong, Roth, Sharin E, Brock, William J, Brouwer, Kim L R
Published in Drug metabolism and disposition (01.08.2019)
Published in Drug metabolism and disposition (01.08.2019)
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Journal Article
Next‐Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development
Roth, Sharin E., Avigan, Mark I., Bourdet, David, Brott, David, Church, Rachel, Dash, Ajit, Keller, Douglas, Sherratt, Philip, Watkins, Paul B., Westcott‐Baker, Lucas, Lentini, Silvia, Merz, Michael, Ramaiah, Lila, Ramaiah, Shashi K., Stanley, Ann Marie, Marcinak, John
Published in Clinical pharmacology and therapeutics (01.02.2020)
Published in Clinical pharmacology and therapeutics (01.02.2020)
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Journal Article
miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model
Mosedale, Merrie, Eaddy, J Scott, Trask, O Joseph, Holman, Natalie S, Wolf, Kristina K, LeCluyse, Edward, Ware, Brenton R, Khetani, Salman R, Lu, Jingtao, Brock, William J, Roth, Sharin E, Watkins, Paul B
Published in Toxicological sciences (01.01.2018)
Published in Toxicological sciences (01.01.2018)
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Journal Article
Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease
Beaudoin, James J, Bezençon, Jacqueline, Cao, Yanguang, Mizuno, Katsuhiko, Roth, Sharin E, Brock, William J, Brouwer, Kim L R
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Journal Article
Simultaneous quantitation of delamanid (OPC-67683) and its eight metabolites in human plasma using UHPLC–MS/MS
Meng, Min, Smith, Benjamin, Johnston, Brad, Carter, Spencer, Brisson, Jerry, Roth, Sharin E.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2015)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2015)
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Journal Article
Bile Acids as Potential Biomarkers to Assess Liver Impairment in Polycystic Kidney Disease
Brock, William J, Beaudoin, James J, Slizgi, Jason R, Su, Mingming, Jia, Wei, Roth, Sharin E, Brouwer, Kim L R
Published in International journal of toxicology (01.03.2018)
Published in International journal of toxicology (01.03.2018)
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Journal Article
Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach
Mosedale, Merrie, Kim, Yunjung, Brock, William J, Roth, Sharin E, Wiltshire, Tim, Eaddy, J Scott, Keele, Gregory R, Corty, Robert W, Xie, Yuying, Valdar, William, Watkins, Paul B
Published in Toxicological sciences (01.04.2017)
Published in Toxicological sciences (01.04.2017)
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Journal Article
Polycystic kidney disease alters the hepatobiliary disposition of tolvaptan and metabolites
Beaudoin, James J., Bezençon, Jacqueline, Cao, Yanguang, Roth, Sharin, Brock, William, Mizuno, Katsuhiko, Brouwer, Kim L.R.
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Journal Article
The Predicting Renal Outcomes in Polycystic Kidney Disease (PROPKD) Score for Estimating Risk of Rapid Progression and Treatment Benefit in Autosomal Dominant Polycystic Kidney Disease (ADPKD): TH-PO387
Fomin, Vitalay, Jiang, Huan, Roth, Sharin
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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Journal Article
Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite
Hammond, Sean, Gibson, Andrew, Jaruthamsophon, Kanoot, Roth, Sharin, Mosedale, Merrie, Naisbitt, Dean J
Published in Toxicological sciences (06.01.2021)
Published in Toxicological sciences (06.01.2021)
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Journal Article
Metabolomic Analysis of Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD): Associations with Disease Progression and Treatment: PO1218
Sundar, Shirin, Roth, Sharin, Hajarnis, Sachin S., Westcott-Baker, Lucas, Mccormick, Linda, Ramaswamy, Bharath, Chapman, Arlene B.
Published in Journal of the American Society of Nephrology (01.10.2021)
Published in Journal of the American Society of Nephrology (01.10.2021)
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Journal Article
Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach
Mosedale, Merrie, Kim, Yunjung, Brock, William J., Roth, Sharin E., Wiltshire, Tim, Scott Eaddy, J., Keele, Gregory R., Corty, Robert W., Xie, Yuying, Valdar, William, Watkins, Paul B.
Published in Toxicological sciences (01.04.2017)
Published in Toxicological sciences (01.04.2017)
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Journal Article
Soluble Urokinase Plasminogen Activator Receptor and Decline in Kidney Function in Autosomal Dominant Polycystic Kidney Disease
Hayek, Salim S, Landsittel, Douglas P, Wei, Changli, Zeier, Martin, Yu, Alan S L, Torres, Vicente E, Roth, Sharin, Pao, Christina S, Reiser, Jochen
Published in Journal of the American Society of Nephrology (01.07.2019)
Published in Journal of the American Society of Nephrology (01.07.2019)
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Journal Article
SP262CAN WE FURTHER ENRICH ADPKD CLINICAL TRIALS FOR RAPIDLY PROGRESSIVE PATIENTS? APPLICATION OF THE PROPKD SCORE IN THE TEMPO TRIAL
Cornec-Le Gall, Emilie, Devuyst, Olivier, Gansevoort, Ron, Perrone, Ron, Chapman, Arlene, Czerwiec, Frank, Ouyang, John, Zhou-CW, Wen, Blais, Jaime, Roth, Sharin, Heyer, Christina, Mauritz, Sarah, Le Meur, Yannick, Torres, Vicente, Harris, Peter
Published in Nephrology, dialysis, transplantation (01.05.2016)
Published in Nephrology, dialysis, transplantation (01.05.2016)
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Development of Calcitonin Salmon Nasal Spray: Similarity of Peptide Formulated in Chlorobutanol Compared to Benzalkonium Chloride as Preservative
Costantino, Henry R., Culley, Heather, Chen, Lishan, Morris, Daniel, Houston, Michael, Roth, Sharin, Phoenix, Mary Jo, Foerder, Chuck, Philo, John S., Arakawa, Tsutomu, Eidenschink, Lisa, Andersen, Niels H., Brandt, Gordon, Quay, Steven C.
Published in Journal of pharmaceutical sciences (01.10.2009)
Published in Journal of pharmaceutical sciences (01.10.2009)
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