Search Results - "Roth, Bruce D." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

by Park, William K.C., Kennedy, Robert M., Larsen, Scott D., Miller, Steve, Roth, Bruce D., Song, Yuntao, Steinbaugh, Bruce A., Sun, Kevin, Tait, Bradley D., Kowala, Mark C., Trivedi, Bharat K., Auerbach, Bruce, Askew, Valerie, Dillon, Lisa, Hanselman, Jeffrey C., Lin, Zhiwu, Lu, Gina H., Robertson, Andrew, Sekerke, Catherine
Published in Bioorganic & medicinal chemistry (01.02.2008)

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Journal Article

Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors

Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors

by O'Brien, Patrick M, Ortwine, Daniel F, Pavlovsky, Alexander G, Picard, Joseph A, Sliskovic, Drago R, Roth, Bruce D, Dyer, Richard D, Johnson, Linda L, Man, Chiu Fai, Hallak, Hussein
Published in Journal of medicinal chemistry (27.01.2000)

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Journal Article

Medicinal chemistry approaches to personalized medicine

Medicinal chemistry approaches to personalized medicine

by Lackey, Karen, Roth, Bruce, Mannhold, Raimund, Kubinyi, Hugo, Folkers, Gerd
Year of Publication 2013

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eBook

Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor

Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor

by Li, Jie Jack, Carson, Kenneth G, Trivedi, Bharat K, Yue, Wen Song, Ye, Qing, Glynn, Roberta A, Miller, Steven R, Connor, David T, Roth, Bruce D, Luly, Jay R, Low, Joseph E, Heilig, David J, Yang, Weixing, Qin, Shixin, Hunt, Stephen
Published in Bioorganic & medicinal chemistry (15.08.2003)

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Journal Article

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series

by Song, Yuntao, Connor, David T, Doubleday, Robert, Sorenson, Roderick J, Sercel, Anthony D, Unangst, Paul C, Roth, Bruce D, Gilbertsen, Richard B, Chan, Kam, Schrier, Denis J, Guglietta, Antonio, Bornemeier, Dirk A, Dyer, Richard D
Published in Journal of medicinal chemistry (08.04.1999)

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Journal Article

1 The Discovery and Development of Atorvastatin, A Potent Novel Hypolipidemic Agent

1 The Discovery and Development of Atorvastatin, A Potent Novel Hypolipidemic Agent

by Roth, Bruce D.
Published in Progress in Medicinal Chemistry (2002)

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Book Chapter

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

by Roth, Bruce D, Blankley, C. J, Chucholowski, A. W, Ferguson, E, Hoefle, M. L, Ortwine, D. F, Newton, R. S, Sekerke, C. S, Sliskovic, D. R, Wilson, M
Published in Journal of medicinal chemistry (01.01.1991)

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Journal Article

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

by Roth, Bruce D, Blankley, C. John, Hoefle, Milton L, Holmes, Ann, Roark, W. Howard, Trivedi, Bharat K, Essenburg, Arnold D, Kieft, Karen A, Krause, Brian R, Stanfield, Richard L
Published in Journal of medicinal chemistry (01.05.1992)

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Journal Article

Contemporary drug synthesis

Contemporary drug synthesis

by Li, Jie Jack, Johnson, Douglas S, Sliskovic, Drago R, Roth, Bruce D
Year of Publication 2004

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eBook

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series

by Song, Yuntao, Connor, David T, Sercel, Anthony D, Sorenson, Roderick J, Doubleday, Robert, Unangst, Paul C, Roth, Bruce D, Beylin, Vlad G, Gilbertsen, Richard B, Chan, Kam, Schrier, Denis J, Guglietta, Antonio, Bornemeier, Dirk A, Dyer, Richard D
Published in Journal of medicinal chemistry (08.04.1999)

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Journal Article

Novel Nonpeptide CCK-B Antagonists: Design and Development of Quinazolinone Derivatives as Potent, Selective, and Orally Active CCK-B Antagonists

Novel Nonpeptide CCK-B Antagonists: Design and Development of Quinazolinone Derivatives as Potent, Selective, and Orally Active CCK-B Antagonists

by Padia, Janak K, Field, Mark, Hinton, Joanna, Meecham, Ken, Pablo, Julius, Pinnock, Rob, Roth, Bruce D, Singh, Lakhbir, Suman-Chauhan, Nirmala, Trivedi, Bharat K, Webdale, Louise
Published in Journal of medicinal chemistry (26.03.1998)

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Journal Article

Metabolism and Excretion of Atorvastatin in Rats And Dogs

Metabolism and Excretion of Atorvastatin in Rats And Dogs

by BLACK, A. E, HAYES, R. N, ROTH, B. D, WOO, P, WOOLF, T. F
Published in Drug metabolism and disposition (01.08.1999)

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Journal Article

Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus

Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus

by Roth, Bruce D, Ortwine, D. F, Hoefle, M. L, Stratton, C. D, Sliskovic, D. R, Wilson, M. W, Newton, R. S
Published in Journal of medicinal chemistry (01.01.1990)

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Journal Article

ACAT inhibitors: evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents

ACAT inhibitors: evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents

by Roth, Bruce D.
Published in Drug discovery today (1998)

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Journal Article

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

by Roth, Bruce D, Bocan, Thomas M. A, Blankley, C. John, Chucholowski, Alexander W, Creger, Paul L, Creswell, Mark W, Ferguson, Erika, Newton, Roger S, O'Brien, Patrick
Published in Journal of medicinal chemistry (01.01.1991)

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Journal Article

Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel .beta.-keto amides as hypocholesterolemic agents

Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel .beta.-keto amides as hypocholesterolemic agents

by Augelli-Szafran, Corinne E, Blankley, C. John, Roth, Bruce D, Trivedi, Bharat K, Bousley, Richard F, Essenburg, Arnold D, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L
Published in Journal of medicinal chemistry (01.10.1993)

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Journal Article

Inhibitors of lipoprotein(a) assembly

Inhibitors of lipoprotein(a) assembly

by Sexton, Karen E, Lee, Helen T, Massa, Mark, Padia, Janak, Patt, William C, Liao, Peggy, Pontrello, Jason K, Roth, Bruce D, Spahr, Mark A, Ramharack, Randy
Published in Bioorganic & medicinal chemistry (03.11.2003)

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Journal Article

THE CONVERGENT SYNTHESIS OF CI-981, AN OPTICALLY-ACTIVE, HIGHLY POTENT, TISSUE SELECTIVE INHIBITOR OF HMG-COA REDUCTASE

THE CONVERGENT SYNTHESIS OF CI-981, AN OPTICALLY-ACTIVE, HIGHLY POTENT, TISSUE SELECTIVE INHIBITOR OF HMG-COA REDUCTASE

by BAUMANN, KL, BUTLER, DE, DEERING, CF, MENNEN, KE, MILLAR, A, NANNINGA, TN, PALMER, CW, ROTH, BD
Published in Tetrahedron letters (01.04.1992)

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Journal Article

(S)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of Pain

(S)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of Pain

by Song, Yuntao, Bowersox, S. Scott, Connor, David T, Dooley, David J, Lotarski, Susan M, Malone, Thomas, Miljanich, George, Millerman, Elizabeth, Rafferty, Michael F, Rock, David, Roth, Bruce D, Schmidt, Joann, Stoehr, Sally, Szoke, Balazs G, Taylor, Charles, Vartanian, Mark, Wang, Yong-Xiang
Published in Journal of medicinal chemistry (21.09.2000)

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Journal Article

Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation

Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation

by Bocan, Thomas M.A., Mazur, Michelle J., Bak Mueller, Sandra, Brown, Edie Quenby, Sliskovic, D.Robert, O'Brien, Patrick M., Creswell, Mark W., Lee, Helen, Uhlendorf, Paul D., Roth, Bruce D., Newton, Roger S.
Published in Atherosclerosis (01.11.1994)

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