CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging
Stebbeds, William, Raniga, Kavita, Standing, David, Wallace, Iona, Bayliss, James, Brown, Andrew, Kasprowicz, Richard, Dalmas Wilk, Deidre, Deakyne, Julianna, Clements, Peter, Chaudhary, Khuram W, Rossman, Eric I, Bahinski, Anthony, Francis, Jo
Published in Toxicological sciences (18.07.2023)
Published in Toxicological sciences (18.07.2023)
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Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes
Saleem, Umber, van Meer, Berend J, Katili, Puspita A, Mohd Yusof, Nurul A N, Mannhardt, Ingra, Garcia, Ana Krotenberg, Tertoolen, Leon, de Korte, Tessa, Vlaming, Maria L H, McGlynn, Karen, Nebel, Jessica, Bahinski, Anthony, Harris, Kate, Rossman, Eric, Xu, Xiaoping, Burton, Francis L, Smith, Godfrey L, Clements, Peter, Mummery, Christine L, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris
Published in Toxicological sciences (01.07.2020)
Published in Toxicological sciences (01.07.2020)
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Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute
Vargas, Hugo M., Rossman, Eric I., Wisialowski, Todd A., Nichols, Jill, Pugsley, Michael K., Roche, Brian, Gintant, Gary A., Greiter-Wilke, Andrea, Kleiman, Robert B., Valentin, Jean-Pierre, Leishman, Derek J.
Published in Journal of pharmacological and toxicological methods (01.05.2023)
Published in Journal of pharmacological and toxicological methods (01.05.2023)
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Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As
Rossman, Eric I., Wisialowski, Todd A., Vargas, Hugo M., Valentin, Jean-Pierre, Rolf, Michael G., Roche, Brian M., Riley, Steve, Pugsley, Michael K., Nichols, Jill, Li, Dingzhou, Leishman, Derek J., Kleiman, Robert B., Greiter-Wilke, Andrea, Gintant, Gary A., Engwall, Michael J., Delaunois, Annie, Authier, Simon
Published in Journal of pharmacological and toxicological methods (01.09.2023)
Published in Journal of pharmacological and toxicological methods (01.09.2023)
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Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment
Wisialowski, Todd A., Ether, Nick, Foley, C. Michael, Kleiman, Robert, Koshman, Yevgeniya, Leishman, Derek, Martel, Eric, Nichols, Jill V., Popp, Julia, Rajamani, Sridharan, Riley, Steve, Rossman, Eric I., Vargas, Hugo M.
Published in Journal of pharmacological and toxicological methods (01.07.2024)
Published in Journal of pharmacological and toxicological methods (01.07.2024)
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Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium
Boulay, Emmanuel, Authier, Simon, Bartko, Theresa, Greiter-Wilke, Andrea, Leishman, Derek, Li, Dingzhou, Nichols, Jill V., Pierson, Jennifer, Rossman, Eric I., Valentin, Jean-Pierre, Vicente, Jose, Walisser, Jacqueline, Troncy, Eric, Wisialowski, Todd A.
Published in Journal of pharmacological and toxicological methods (01.09.2024)
Published in Journal of pharmacological and toxicological methods (01.09.2024)
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A novel cardiovascular systems model to quantify drugs effects on the inter‐relationship between contractility and other hemodynamic variables
Fu, Yu, Taghvafard, Hadi, Said, Medhat M., Rossman, Eric I., Collins, Teresa A., Billiald‐Desquand, Stéphanie, Leishman, Derek, Graaf, Piet H., Hasselt, J. G. Coen, Snelder, Nelleke
Published in CPT: pharmacometrics and systems pharmacology (01.05.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.05.2022)
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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
Delaunois, Annie, Abernathy, Matthew, Anderson, Warren D., Beattie, Kylie A., Chaudhary, Khuram W., Coulot, Julie, Gryshkova, Vitalina, Hebeisen, Simon, Holbrook, Mark, Kramer, James, Kuryshev, Yuri, Leishman, Derek, Lushbough, Isabel, Passini, Elisa, Redfern, Will S., Rodriguez, Blanca, Rossman, Eric I., Trovato, Cristian, Wu, Caiyun, Valentin, Jean‐Pierre
Published in Clinical and Translational Science (01.05.2021)
Published in Clinical and Translational Science (01.05.2021)
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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium
Boulay, Emmanuel, Abernathy, Matthew M, Chui, Ray, Friedrichs, Gregory S, Gendron-Parra, Nicolas, Greiter-Wilke, Andrea, Guillon, Jean-Michel, Koerner, John E, Menard, Ariane, Steidl-Nichols, Jill, Pierson, Jennifer, Pugsley, Michael K, Rossman, Eric I, Strauss, David, Troncy, Eric, Valentin, Jean-Pierre, Wisialowski, Todd, Authier, Simon
Published in International journal of toxicology (01.01.2019)
Published in International journal of toxicology (01.01.2019)
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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium
Guth, Brian D., Chiang, Alan Y., Doyle, Jennifer, Engwall, Michael J., Guillon, Jean-Michel, Hoffmann, Peter, Koerner, John, Mittelstadt, Scott, Ottinger, Sean, Pierson, Jennifer Beck, Pugsley, Michael K., Rossman, Eric I., Walisser, Jacqueline, Sarazan, R. Dustan
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis
Boulay, Emmanuel, Miraucourt, Loïs S., Pugsley, Michael K., Abernathy, Matthew M., Chui, Ray, Dalton, Jill, Demers, Marjorie, Dybdal, Noel, Gazaille, Elissa, Greiter-Wilke, Andrea, Hoffmann, Peter, Huang, Hai, LaDuke, Carrie, Norton, Kevin, Pierson, Jennifer B., Reeves, Isabelle, Roche, Brian, Rossman, Eric I., Schultze, Albert E., Tang, Hai-Ming, Wisialowski, Todd, Authier, Simon
Published in Journal of pharmacological and toxicological methods (01.05.2023)
Published in Journal of pharmacological and toxicological methods (01.05.2023)
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The effect of DMSO on the contraction and relaxation of isolated thoracic aorta of the CRL:WI(Han) rat
Payseur, Jason D., Wu, Xuejun, Turner, Sandra L., Bayrak, Konuralp, Bahinski, Anthony, Rossman, Eric I.
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Simultaneous measurement of contraction, voltage and calcium in HIPSC-CMS for the detection of inotropic effects under blinded conditions
de Korte, Tessa, van Meer, Berend, Garcia, Ana Krotenberg, Tertoolen, Leon, Clements, Peter J., Bahinski, Anthony, Rossman, Eric I., Xu, Xiaoping, Turner, Samantha, Denning, Chris, Vlaming, Marijn, Braam, Stefan, Mummery, Christine
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation
Rossman, Eric I., Cools, Frank, Cordes, Jason, Dhuyvetter, Deborah, Doyle, Jennifer M., Friedrichs, Gregory S., Guth, Brian, Neradilek, Moni B., Parish, Stanley T., Pierson, Jennifer B., Polissar, Nayak, Tang, Hai-Ming
Published in Journal of pharmacological and toxicological methods (01.09.2020)
Published in Journal of pharmacological and toxicological methods (01.09.2020)
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Evaluation of a method utilizing PhysioFlow®, a novel signal morphology-based form of impedance cardiography, to measure cardiac output in the conscious beagle
Payseur, Jason D., Rigney, John J., Turner, Sandra L., Wu, XueJun, Murphy, Dennis J., Rossman, Eric I.
Published in Journal of pharmacological and toxicological methods (01.09.2016)
Published in Journal of pharmacological and toxicological methods (01.09.2016)
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The Gap Junction Modifier, GAP-134 [(2S,4R)-1-(2-Aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic Acid], Improves Conduction and Reduces Atrial Fibrillation/Flutter in the Canine Sterile Pericarditis Model
Rossman, Eric I, Liu, Kun, Morgan, Gwen A, Swillo, Robert E, Krueger, Julie A, Gardell, Stephen J, Butera, John, Gruver, Matthew, Kantrowitz, Joel, Feldman, Hal S, Petersen, Jørgen S, Haugan, Ketil, Hennan, James K
Published in The Journal of pharmacology and experimental therapeutics (01.06.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2009)
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An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs
Pugsley, Michael K., Guth, Brian, Chiang, Alan Y., Doyle, Jennifer M., Engwall, Michael, Guillon, Jean-Michel, Hoffmann, Peter K., Koerner, John E., Mittelstadt, Scott W., Pierson, Jennifer Beck, Rossman, Eric I., Sarazan, Dustan R., Parish, Stanley T.
Published in Journal of pharmacological and toxicological methods (01.05.2017)
Published in Journal of pharmacological and toxicological methods (01.05.2017)
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Journal Article
An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs
Pugsley, Michael K, Guth, Brian, Chiang, Alan Y, Doyle, Jennifer M, Engwall, Michael, Guillon, Jean-Michel, Hoffmann, Peter K, Koerner, John E, Mittelstadt, Scott W, Pierson, Jennifer Beck, Rossman, Eric I, Sarazan, Dustan R, Parish, Stanley T
Published in Journal of pharmacological and toxicological methods (01.05.2017)
Published in Journal of pharmacological and toxicological methods (01.05.2017)
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Journal Article
Sex-based differences in myocardial contractile reserve
Petre, Rebecca E, Quaile, Michael P, Rossman, Eric I, Ratcliffe, Sarah J, Bailey, Beth A, Houser, Steven R, Margulies, Kenneth B
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.02.2007)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.02.2007)
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Journal Article
Effects of Chronic Gap Junction Conduction–Enhancing Antiarrhythmic Peptide GAP-134 Administration on Experimental Atrial Fibrillation in Dogs
Laurent, Gabriel, Leong-Poi, Howard, Mangat, Iqwal, Moe, Gordon W, Hu, Xudong, So, Petsy Pui-Sze, Tarulli, Emidio, Ramadeen, Andrew, Rossman, Eric I, Hennan, James K, Dorian, Paul
Published in Circulation. Arrhythmia and electrophysiology (01.04.2009)
Published in Circulation. Arrhythmia and electrophysiology (01.04.2009)
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