The TLR4 antagonist Eritoran protects mice from lethal influenza infection
Shirey, Kari Ann, Lai, Wendy, Scott, Alison J., Lipsky, Michael, Mistry, Pragnesh, Pletneva, Lioubov M., Karp, Christopher L., McAlees, Jaclyn, Gioannini, Theresa L., Weiss, Jerrold, Chen, Wilbur H., Ernst, Robert K., Rossignol, Daniel P., Gusovsky, Fabian, Blanco, Jorge C. G., Vogel, Stefanie N.
Published in Nature (London) (23.05.2013)
Published in Nature (London) (23.05.2013)
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Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist
Mullarkey, Maureen, Rose, Jeffrey R, Bristol, John, Kawata, Tsutomu, Kimura, Akufumi, Kobayashi, Seiichi, Przetak, Melinda, Chow, Jesse, Gusovsky, Fabian, Christ, William J, Rossignol, Daniel P
Published in The Journal of pharmacology and experimental therapeutics (01.03.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2003)
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Journal Article
Blocking of Responses to Endotoxin by E5564 in Healthy Volunteers with Experimental Endotoxemia
Lynn, Melvyn, Rossignol, Daniel P, Wheeler, Janice L, Kao, Richard J, Perdomo, Carlos A, Noveck, Robert, Vargas, Ramon, D’Angelo, Tony, Gotzkowsky, Sandra, McMahon, F. Gilbert
Published in The Journal of infectious diseases (15.02.2003)
Published in The Journal of infectious diseases (15.02.2003)
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Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis: The ACCESS Randomized Trial
Opal, Steven M, Laterre, Pierre-Francois, Francois, Bruno, LaRosa, Steven P, Angus, Derek C, Mira, Jean-Paul, Wittebole, Xavier, Dugernier, Thierry, Perrotin, Dominique, Tidswell, Mark, Jauregui, Luis, Krell, Kenneth, Pachl, Jan, Takahashi, Takeshi, Peckelsen, Claus, Cordasco, Edward, Chang, Chia-Sheng, Oeyen, Sandra, Aikawa, Naoki, Maruyama, Tatsuya, Schein, Roland, Kalil, Andre C, Van Nuffelen, Marc, Lynn, Melvyn, Rossignol, Daniel P, Gogate, Jagadish, Roberts, Mary B, Wheeler, Janice L, Vincent, Jean-Louis
Published in JAMA : the journal of the American Medical Association (20.03.2013)
Published in JAMA : the journal of the American Medical Association (20.03.2013)
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Journal Article
Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers
ROSSIGNOL, Daniel P, WASAN, Kishor M, CHOO, Eugene, YAU, Edwin, WONG, Nancy, ROSE, Jeffrey, MORAN, Jeffrey, LYNN, Melvyn
Published in Antimicrobial Agents and Chemotherapy (01.09.2004)
Published in Antimicrobial Agents and Chemotherapy (01.09.2004)
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Journal Article
Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia
Lynn, Melvyn, Wong, Y Nancy, Wheeler, Janice L, Kao, Richard J, Perdomo, Carlos A, Noveck, Robert, Vargas, Ramon, D'Angelo, Tony, Gotzkowsky, Sandra, McMahon, F Gilbert, Wasan, Kishor M, Rossignol, Daniel P
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
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Journal Article
A Novel Class of Endotoxin Receptor Agonists with Simplified Structure, Toll-Like Receptor 4-Dependent Immunostimulatory Action, and Adjuvant Activity
Hawkins, Lynn D, Ishizaka, Sally T, McGuinness, Pamela, Zhang, Huiming, Gavin, Wendy, DeCosta, Bruce, Meng, Zhaoyang, Yang, Hu, Mullarkey, Maureen, Young, Donna W, Yang, Hua, Rossignol, Daniel P, Nault, Anneliese, Rose, Jeffrey, Przetak, Melinda, Chow, Jesse C, Gusovsky, Fabian
Published in The Journal of pharmacology and experimental therapeutics (01.02.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2002)
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Phase I Study of E7820, an Oral Inhibitor of Integrin α-2 Expression with Antiangiogenic Properties, in Patients with Advanced Malignancies
MITA, Monica, KELLY, Kevin R, GILES, Francis J, ROWINSKY, Eric K, TAKIMOTO, Chris, MITA, Alain, RICART, Alejandro D, ROMERO, Ofelia, TOLCHER, Anthony, HOOK, Laurel, OKEREKE, Chukwuemeka, KRIVELEVICH, Ilya, ROSSIGNOL, Daniel P
Published in Clinical cancer research (2011)
Published in Clinical cancer research (2011)
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Association of the Endotoxin Antagonist E5564 with High-Density Lipoproteins In Vitro: Dependence on Low-Density and Triglyceride-Rich Lipoprotein Concentrations
WASAN, Kishor M, SIVAK, Olena, COTE, Richard A, MACLNNES, Aaron I, BOULANGER, Kathy D, LYNN, Melvyn, CHRIST, William J, HAWKINS, Lynn D, ROSSIGNOL, Daniel P
Published in Antimicrobial Agents and Chemotherapy (01.09.2003)
Published in Antimicrobial Agents and Chemotherapy (01.09.2003)
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LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation
Cooke, K R, Gerbitz, A, Crawford, J M, Teshima, T, Hill, G R, Tesolin, A, Rossignol, D P, Ferrara, J L
Published in The Journal of clinical investigation (15.06.2001)
Published in The Journal of clinical investigation (15.06.2001)
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Journal Article
Consequences of Interaction of a Lipophilic Endotoxin Antagonist with Plasma Lipoproteins
ROSE, J. R, MULLARKEY, M. A, CHRIST, W. J, HAWKINS, L. D, LYNN, M, KISHI, Y, WASAN, K. M, PETEHERYCH, K, ROSSIGNOL, D. P
Published in Antimicrobial Agents and Chemotherapy (01.03.2000)
Published in Antimicrobial Agents and Chemotherapy (01.03.2000)
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Journal Article
A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
Bennett-Guerrero, Elliott, Grocott, Hilary P, Levy, Jerrold H, Stierer, Kevin A, Hogue, Charles W, Cheung, Albert T, Newman, Mark F, Carter, Alison A, Rossignol, Daniel P, Collard, Charles D
Published in Anesthesia and analgesia (01.02.2007)
Published in Anesthesia and analgesia (01.02.2007)
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Journal Article
Suppression of Murine Endotoxin Response by E5531, a Novel Synthetic Lipid A Antagonist
KOBAYASHI, S, KAWATA, T, KIMURA, A, MIYAMOTO, K, KATAYAMA, K, YAMATSU, I, ROSSIGNOL, D. P, CHRIST, W. J, KISHI, Y
Published in Antimicrobial Agents and Chemotherapy (01.11.1998)
Published in Antimicrobial Agents and Chemotherapy (01.11.1998)
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Journal Article
TLR4 antagonists for endotoxemia and beyond
Rossignol, Daniel P, Lynn, Melvyn
Published in Current opinion in investigational drugs (London, England : 2000) (01.05.2005)
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Published in Current opinion in investigational drugs (London, England : 2000) (01.05.2005)
Journal Article
Lipoprotein Distribution of a Novel Endotoxin Antagonist, E5531, in Plasma from Human Subjects with Various Lipid Levels
WASAN, K. M, STROBEL, F. W, PARROTT, S. C, LYNN, M, CHRIST, W. J, HAWKINS, L. D, ROSSIGNOL, D. P
Published in Antimicrobial Agents and Chemotherapy (01.10.1999)
Published in Antimicrobial Agents and Chemotherapy (01.10.1999)
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Journal Article
Inhibition of endotoxin response by synthetic TLR4 antagonists
Hawkins, Lynn D, Christ, William J, Rossignol, Daniel P
Published in Current topics in medicinal chemistry (01.01.2004)
Published in Current topics in medicinal chemistry (01.01.2004)
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Journal Article
Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men
Aikawa, Naoki, Okubo, Yoshio, Lynn, Melvyn, Rossignol, Daniel P, Wong, Y Nancy, Schuck, Edgar, Kitahara, Yasumi, Nakano, Tomohisa, Sivak, Olena, Wasan, Kishor M, Nagy, Christa, Yen, Mark
Published in Innate immunity (London, England) (01.12.2012)
Published in Innate immunity (London, England) (01.12.2012)
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Journal Article
Influence of Plasma Cholesterol and Triglyceride Concentrations and Eritoran (E5564) Micelle Size on its Plasma Pharmacokinetics and Ex Vivo Activity Following Single Intravenous Bolus Dose Into Healthy Female Rabbits
Wasan, Kishor M., Risovic, Verica, Sivak, Olena, Lee, Stephen D., Mason, Douglas X., Chiklis, Gregory R., McShane, Jim, Lynn, Melvyn, Wong, Nancy, Rossignol, Daniel P.
Published in Pharmaceutical research (2008)
Published in Pharmaceutical research (2008)
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Journal Article
E5531, a synthetic non‐toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide
Kawata, Tsutomu, Bristol, John R, Rossignol, Daniel P, Rose, Jeffrey R, Kobayashi, Seiichi, Yokohama, Hiromitsu, Ishibashi, Akira, Christ, William J, Katayama, Koichi, Yamatsu, Isao, Kishi, Yoshito
Published in British journal of pharmacology (01.06.1999)
Published in British journal of pharmacology (01.06.1999)
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