Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor
Butler, Christopher R., Popiolek, Michael, McAllister, Laura A., LaChapelle, Erik A., Kramer, Melissa, Beck, Elizabeth M., Mente, Scot, Brodney, Michael A., Brown, Matthew, Gilbert, Adam, Helal, Chris, Ogilvie, Kevin, Starr, Jeremy, Uccello, Daniel, Grimwood, Sarah, Edgerton, Jeremy, Garst-Orozco, Jonathan, Kozak, Rouba, Lotarski, Susan, Rossi, Amie, Smith, Deborah, O’Connor, Rebecca, Lazzaro, John, Steppan, Claire, Steyn, Stefanus J.
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
Get full text
Journal Article
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor
Butler, Christopher R., Popiolek, Michael, McAllister, Laura A., LaChapelle, Erik A., Kramer, Melissa, Beck, Elizabeth M., Mente, Scot, Brodney, Michael A., Brown, Matthew, Gilbert, Adam, Helal, Chris, Ogilvie, Kevin, Starr, Jeremy, Uccello, Daniel, Grimwood, Sarah, Edgerton, Jeremy, Garst-Orozco, Jonathan, Kozak, Rouba, Lotarski, Susan, Rossi, Amie, Smith, Deborah, O’Connor, Rebecca, Lazzaro, John, Steppan, Claire, Steyn, Stefanus J.
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
Get full text
Journal Article
NOVEL NON-CATECHOL D1 RECEPTOR AGONISTS EXHIBIT SUSTAINED PHARMACOLOGICAL ACTIVITY
Tierney, Patrick L., Allen, John A., Volfson, Dmitri, Lotarski, Susan, Rossi, Amie, Gray, David L., Kozak, Rouba
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
Get full text
Journal Article
α5 nAChR modulation of the prefrontal cortex makes attention resilient
Howe, William M., Brooks, Julie L., Tierney, Patrick L., Pang, Jincheng, Rossi, Amie, Young, Damon, Dlugolenski, Keith, Guillmette, Ed, Roy, Marc, Hales, Katherine, Kozak, Rouba
Published in Brain Structure and Function (01.03.2018)
Published in Brain Structure and Function (01.03.2018)
Get full text
Journal Article