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Calle, Roberto A, Amin, Neeta B, Carvajal-Gonzalez, Santos, Ross, Trenton T, Bergman, Arthur, Aggarwal, Sudeepta, Crowley, Collin, Rinaldi, Anthony, Mancuso, Jessica, Aggarwal, Naresh, Somayaji, Veena, Inglot, Malgorzata, Tuthill, Theresa A, Kou, Kou, Boucher, Magalie, Tesz, Greg, Dullea, Robert, Bence, Kendra K, Kim, Albert M, Pfefferkorn, Jeffrey A, Esler, William P
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Published in Nature medicine (01.10.2021)
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Murine HSD17β13 does not control liver steatosis and modestly impacts fibrosis in a sex- and diet-specific manner
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The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats
Erion, Derek M, Lapworth, Amanda, Amor, Paul A, Bai, Guoyun, Vera, Nicholas B, Clark, Ronald W, Yan, Qingyun, Zhu, Yimin, Ross, Trenton T, Purkal, Julie, Gorgoglione, Matthew, Zhang, Guodong, Bonato, Vinicius, Baker, Levenia, Barucci, Nicole, D'Aquila, Theresa, Robertson, Alan, Aiello, Robert J, Yan, Jiangli, Trimmer, Jeff, Rolph, Timothy P, Pfefferkorn, Jeffrey A
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Published in PloS one (23.05.2014)
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The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes
Linden, Melissa A., Ross, Trenton T., Beebe, David A., Gorgoglione, Matthew F., Hamilton, Karyn L., Miller, Benjamin F., Braun, Barry, Esler, William P.
Published in Metabolism, clinical and experimental (01.08.2019)
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Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
Gutierrez, Jemy A., Liu, Wei, Perez, Sylvie, Xing, Gang, Sonnenberg, Gabriele, Kou, Kou, Blatnik, Matt, Allen, Richard, Weng, Yan, Vera, Nicholas B., Chidsey, Kristin, Bergman, Arthur, Somayaji, Veena, Crowley, Collin, Clasquin, Michelle F., Nigam, Anu, Fulham, Melissa A., Erion, Derek M., Ross, Trenton T., Esler, William P., Magee, Thomas V., Pfefferkorn, Jeffrey A., Bence, Kendra K., Birnbaum, Morris J., Tesz, Gregory J.
Published in Molecular metabolism (Germany) (01.06.2021)
Published in Molecular metabolism (Germany) (01.06.2021)
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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Futatsugi, Kentaro, Cabral, Shawn, Kung, Daniel W., Huard, Kim, Lee, Esther, Boehm, Markus, Bauman, Jonathan, Clark, Ronald W., Coffey, Steven B., Crowley, Collin, Dechert-Schmitt, Anne-Marie, Dowling, Matthew S., Dullea, Robert, Gosset, James R., Kalgutkar, Amit S., Kou, Kou, Li, Qifang, Lian, Yajing, Loria, Paula M., Londregan, Allyn T., Niosi, Mark, Orozco, Christine, Pettersen, John C., Pfefferkorn, Jeffrey A., Polivkova, Jana, Ross, Trenton T., Sharma, Raman, Stock, Ingrid A., Tesz, Gregory, Wisniewska, Hanna, Goodwin, Bryan, Price, David A.
Published in Journal of medicinal chemistry (24.11.2022)
Published in Journal of medicinal chemistry (24.11.2022)
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Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Ross, Trenton T., Crowley, Collin, Kelly, Kenneth L., Rinaldi, Anthony, Beebe, David A., Lech, Matthew P., Martinez, Robert V., Carvajal-Gonzalez, Santos, Boucher, Magalie, Hirenallur-Shanthappa, Dinesh, Morin, Jeffrey, Opsahl, Alan C., Vargas, Sarah R., Bence, Kendra K., Pfefferkorn, Jeffrey A., Esler, William P.
Published in Cellular and molecular gastroenterology and hepatology (01.01.2020)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2020)
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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Huard, Kim, Ahn, Kay, Amor, Paul, Beebe, David A, Borzilleri, Kris A, Chrunyk, Boris A, Coffey, Steven B, Cong, Yang, Conn, Edward L, Culp, Jeffrey S, Dowling, Matthew S, Gorgoglione, Matthew F, Gutierrez, Jemy A, Knafels, John D, Lachapelle, Erik A, Pandit, Jayvardhan, Parris, Kevin D, Perez, Sylvie, Pfefferkorn, Jeffrey A, Price, David A, Raymer, Brian, Ross, Trenton T, Shavnya, Andre, Smith, Aaron C, Subashi, Timothy A, Tesz, Gregory J, Thuma, Benjamin A, Tu, Meihua, Weaver, John D, Weng, Yan, Withka, Jane M, Xing, Gang, Magee, Thomas V
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Huard, Kim, Smith, Aaron C, Cappon, Gregg, Dow, Robert L, Edmonds, David J, El-Kattan, Ayman, Esler, William P, Fernando, Dilinie P, Griffith, David A, Kalgutkar, Amit S, Ross, Trenton T, Bagley, Scott W, Beebe, David, Bi, Yi-An, Cabral, Shawn, Crowley, Collin, Doran, Shawn D, Dowling, Matthew S, Liras, Spiros, Mascitti, Vincent, Niosi, Mark, Pfefferkorn, Jeffrey A, Polivkova, Jana, Préville, Cathy, Price, David A, Shavnya, Andre, Shirai, Norimitsu, Smith, Andrew H, Southers, James R, Tess, David A, Thuma, Benjamin A, Varma, Manthena V, Yang, Xiaojing
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays
Catlin, Natasha R, Bowman, Christopher J, Campion, Sarah N, Davenport, Scott D, Esler, William P, Kumpf, Steven W, Lewis, Elise M, Nowland, William S, Ross, Trenton T, Stedman, Donald S, Stethem, Christine, Cappon, Gregg D
Published in Toxicological sciences (01.02.2021)
Published in Toxicological sciences (01.02.2021)
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GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner
Smith, Kathleen R, Wang, Wenshan, Miller, Melissa R, Boucher, Magalie, Reynold, Jessica E, Daurio, Natalie A, Li, Dongmei, Hirenallur-Shanthappa, Dinesh, Ahn, Youngwook, Beebe, David A, Kelly, Kenneth L, Ross, Trenton T, Bence, Kendra K, Wan, Min
Published in Cellular and molecular gastroenterology and hepatology (01.01.2024)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2024)
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De novo lipogenesis is essential for platelet production in humans
Kelly, Kenneth L, Reagan, William J, Sonnenberg, Gabriele E, Clasquin, Michelle, Hales, Katherine, Asano, Shoh, Amor, Paul A, Carvajal-Gonzalez, Santos, Shirai, Norimitsu, Matthews, Marcy D, Li, Kelvin W, Hellerstein, Marc K, Vera, Nicholas B, Ross, Trenton T, Cappon, Gregg, Bergman, Arthur, Buckeridge, Clare, Sun, Zhongyuan, Qejvanaj, Enida Ziso, Schmahai, Theodore, Beebe, David, Pfefferkorn, Jeffrey A, Esler, William P
Published in Nature metabolism (01.10.2020)
Published in Nature metabolism (01.10.2020)
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Co-administration of PF-05221304 and PF-06865571 delivers robust whole liver fat reduction and mitigation of acetyl-coa carboxilase inhibitor induced hypertriglyceridemia in patients with NAFLD
Calle, Roberto, Aggarwal, Sudeepta, Mancuso, Jessica, Bergman, Arthur, Somayaji, Veena, Ross, Trenton, Esler, William
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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FRI114 - Co-administration of PF-05221304 and PF-06865571 delivers robust whole liver fat reduction and mitigation of acetyl-coa carboxilase inhibitor induced hypertriglyceridemia in patients with NAFLD
Calle, Roberto, Aggarwal, Sudeepta, Mancuso, Jessica, Bergman, Arthur, Somayaji, Veena, Ross, Trenton, Esler, William
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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PS-109-Partial inhibition of de novo lipogenesis with the acetyl-CoA carboxylase inhibitor PF-05221304 does not increase circulating triglycerides in humans and is sufficient to lower steatosis in rats
Esler, William, Ross, Trenton, Bergman, Arthur, Crowley, Collin, Gonzalez, Santos Carvajal, Beebe, David, Pfefferkorn, Jeffrey A, Amin, Neeta
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis
Mózes, Ferenc E, Lee, Jenny A, Vali, Yasaman, Alzoubi, Osama, Staufer, Katharina, Trauner, Michael, Paternostro, Rafael, Stauber, Rudolf E, Holleboom, Adriaan G, van Dijk, Anne-Marieke, Mak, Anne Linde, Boursier, Jérôme, de Saint Loup, Marc, Shima, Toshihide, Bugianesi, Elisabetta, Gaia, Silvia, Armandi, Angelo, Shalimar, Lupșor-Platon, Monica, Wong, Vincent Wai-Sun, Li, Guanlin, Wong, Grace Lai-Hung, Cobbold, Jeremy, Karlas, Thomas, Wiegand, Johannes, Sebastiani, Giada, Tsochatzis, Emmanuel, Liguori, Antonio, Yoneda, Masato, Nakajima, Atsushi, Hagström, Hannes, Akbari, Camilla, Hirooka, Masashi, Chan, Wah-Kheong, Mahadeva, Sanjiv, Rajaram, Ruveena, Zheng, Ming-Hua, George, Jacob, Eslam, Mohammed, Petta, Salvatore, Pennisi, Grazia, Viganò, Mauro, Ridolfo, Sofia, Aithal, Guruprasad Padur, Palaniyappan, Naaventhan, Lee, Dae Ho, Ekstedt, Mattias, Nasr, Patrik, Cassinotto, Christophe, de Lédinghen, Victor, Berzigotti, Annalisa, Mendoza, Yuly P, Noureddin, Mazen, Truong, Emily, Fournier-Poizat, Céline, Geier, Andreas, Martic, Miljen, Tuthill, Theresa, Anstee, Quentin M, Harrison, Stephen A, Bossuyt, Patrick M, Pavlides, Michael
Published in The lancet. Gastroenterology & hepatology (01.08.2023)
Published in The lancet. Gastroenterology & hepatology (01.08.2023)
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