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Published in Journal of clinical oncology (01.05.2017)
Published in Journal of clinical oncology (01.05.2017)
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The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
Herman, Sarah E M, Montraveta, Arnau, Niemann, Carsten U, Mora-Jensen, Helena, Gulrajani, Michael, Krantz, Fanny, Mantel, Rose, Smith, Lisa L, McClanahan, Fabienne, Harrington, Bonnie K, Colomer, Dolors, Covey, Todd, Byrd, John C, Izumi, Raquel, Kaptein, Allard, Ulrich, Roger, Johnson, Amy J, Lannutti, Brian J, Wiestner, Adrian, Woyach, Jennifer A
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Published in Clinical cancer research (01.06.2017)
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Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients
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Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
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Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL
Reiff, Sean D., Muhowski, Elizabeth M., Guinn, Daphne, Lehman, Amy, Fabian, Catherine A., Cheney, Carolyn, Mantel, Rose, Smith, Lisa, Johnson, Amy J., Young, Wendy B., Johnson, Adam R., Liu, Lichuan, Byrd, John C., Woyach, Jennifer A.
Published in Blood (06.09.2018)
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The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation
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Published in Cancer discovery (01.10.2018)
Published in Cancer discovery (01.10.2018)
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Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia
Maddocks, Kami J, Ruppert, Amy S, Lozanski, Gerard, Heerema, Nyla A, Zhao, Weiqiang, Abruzzo, Lynne, Lozanski, Arletta, Davis, Melanie, Gordon, Amber, Smith, Lisa L, Mantel, Rose, Jones, Jeffrey A, Flynn, Joseph M, Jaglowski, Samantha M, Andritsos, Leslie A, Awan, Farrukh, Blum, Kristie A, Grever, Michael R, Johnson, Amy J, Byrd, John C, Woyach, Jennifer A
Published in JAMA oncology (01.04.2015)
Published in JAMA oncology (01.04.2015)
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Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia
Hing, Zachary A., Mantel, Rose, Beckwith, Kyle A., Guinn, Daphne, Williams, Erich, Smith, Lisa L., Williams, Katie, Johnson, Amy J., Lehman, Amy M., Byrd, John C., Woyach, Jennifer A., Lapalombella, Rosa
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Eμ-TCL1xMyc: A Novel Mouse Model for Concurrent CLL and B-Cell Lymphoma
Lucas, Fabienne, Rogers, Kerry A, Harrington, Bonnie K, Pan, Alexander, Yu, Lianbo, Breitbach, Justin, Bundschuh, Ralf, Goettl, Virginia M, Hing, Zachary A, Kanga, Parviz, Mantel, Rose, Sampath, Deepa, Smith, Lisa L, Wasmuth, Ronni, White, Danielle K, Yan, Pearlly, Byrd, John C, Lapalombella, Rosa, Woyach, Jennifer A
Published in Clinical cancer research (15.10.2019)
Published in Clinical cancer research (15.10.2019)
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Targeting BTK through microRNA in chronic lymphocytic leukemia
Bottoni, Arianna, Rizzotto, Lara, Lai, Tzung-Huei, Liu, Chaomei, Smith, Lisa L., Mantel, Rose, Reiff, Sean, El-Gamal, Dalia, Larkin, Karilyn, Johnson, Amy J., Lapalombella, Rosa, Lehman, Amy, Plunkett, William, Byrd, John C., Blachly, James S., Woyach, Jennifer A., Sampath, Deepa
Published in Blood (29.12.2016)
Published in Blood (29.12.2016)
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The Protein Kinase C Inhibitor MS-553 for the Treatment of Chronic Lymphocytic Leukemia
Muhowski, Elizabeth M., Lehman, Amy M., Reiff, Sean D., Ravikrishnan, Janani, Mantel, Rose, Misra, Shrilekha, Niesman, Michael, Zhang, Kai, Blachly, James S., Sampath, Deepa, Byrd, John C., Woyach, Jennifer
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Evaluation of the novel Bruton′s tyrosine kinase (BTK) inhibitor GDC-0853 in chronic lymphocytic leukemia (CLL) with wild type or C481S mutated BTK
Reiff, Sean David, Guinn, Daphne, Mantel, Rose, Smith, Lisa, Cheney, Carolyn, Johnson, Amy J., Byrd, John C., Woyach, Jennifer Ann
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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The Bruton's Tyrosine Kinase (BTK) Inhibitor ARQ 531 Effectively Inhibits Wild Type and C481S Mutant BTK and Is Superior to Ibrutinib in a Mouse Model of Chronic Lymphocytic Leukemia
Reiff, Sean D., Mantel, Rose, Smith, Lisa L., McWhorter, Samantha, Goettl, Virginia M., Johnson, Amy J., Eathiraj, Sudharsan, Abbadessa, Giovanni, Schwartz, Brian, Byrd, John C., Woyach, Jennifer A.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Exploring the Functional Relevance of BTK Beyond Chronic Lymphocytic Leukemia (CLL) Cells: BTK Expression in Non-Malignant Immune Cells of the Microenvironment Mediates CLL Development and Progression In Vivo
McClanahan, Fabienne, Reiff, Sean D., Guinn, Daphne, Tran, Minh, Beaver, Larry, McWorther, Samantha, Mantel, Rose, Smith, Lisa L., Johnson, Amy J., Byrd, John C., Woyach, Jennifer A.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Inhibitors of Bruton's Tyrosine Kinase Reduce Anti-Red Blood Cell Response in a Murine Model of Autoimmune Hemolytic Anemia
Rogers, Kerry A., Lehman, Amy M., Cheney, Carolyn, Goettl, Virginia M., Mantel, Rose, Smith, Lisa L., Tran, Minh, Johnson, Amy J., Byrd, John C., Woyach, Jennifer A.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Abstract 4471: Novel SF3B1 deletion mutations result in aberrant RNA splicing in CLL patients
Agrawal, Anant A., Seiler, Michael, Brinton, Lindsey, Mantel, Rose, Lapalombella, Rosa, Woyach, Jennifer A., Johnson, Amy J., Yu, Lihua, Byrd, John C., Smith, Peter G., Blachly, James S., Buonamici, Silvia
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Targeting BTK By a microRNA Mechanism in Chronic Lymphocytic Leukemia
Bottoni, Arianna, Lara, Rizzotto, Tzung-Huei, Lai, Mantel, Rose, Simith, Lisa, El-Gamal, Dalia, Johnson, Amy J., Lapalombella, Rosa, Blachly, James S., Byrd, John C., Woyach, Jennifer A., Sampath, Deepa
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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The Eµ-Myc/TCL1 Transgenic Mouse As a New Aggressive B-Cell Malignancy Model Suitable for Preclinical Therapeutics Testing
Rogers, Kerry A., El-Gamal, Dalia, Bonnie, Harrington K., Zachary, Hing A., Virginia, Goettl M., Rose, Mantel, Smith, Lisa L., Yu, Lianbo, Johnson, Amy J., Byrd, John C., Lapalombella, Rosa, Woyach, Jennifer A.
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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The BTK Inhibitor ARQ 531 Targets Ibrutinib Resistant CLL and Richter’s Transformation
Reiff, Sean D., Mantel, Rose, Smith, Lisa L., Greene, JT, Muhowski, Elizabeth M., Fabian, Catherine A., Goettl, Virginia M., Tran, Minh, Harrington, Bonnie K., Rogers, Kerry A., Awan, Farrukh T., Maddocks, Kami, Andritsos, Leslie, Lehman, Amy M., Sampath, Deepa, Lapalombella, Rosa, Eathiraj, Sudharshan, Abbadessa, Giovanni, Schwartz, Brian, Johnson, Amy J., Byrd, John C., Woyach, Jennifer A.
Published in Cancer discovery (09.08.2018)
Published in Cancer discovery (09.08.2018)
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REDX08608, a Novel, Potent and Selective, Reversible BTK Inhibitor with Efficacy and Equivalent Potency Against Wild-Type and Mutant C481S BTK
Guisot, Nicolas E.S., Best, Stuart A., Wright, Victoria, Thomason, Andrew, Woyach, Jennifer A., Mantel, Rose, McClanahan, Fabienne, Abet, Valentina, Castagna, Diana, Cousin, Peggy, Emmerich, Juliette, Ho, Kelvin, Kelly, James Russell, King-Tours, James, Lyons, Kristina, Muller, Melanie, Refuerzo, Julienne, Sargent, Louise, Talab, Fatima, Bingham, Matilda, Phillips, Caroline, Armer, Richard
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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