CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects
González-Lizárraga, Florencia, Ploper, Diego, Ávila, César L., Socías, Sergio B., dos-Santos-Pereira, Mauricio, Machín, Belén, Del-Bel, Elaine, Michel, Patrick Pierre, Pietrasanta, Lía I., Raisman-Vozari, Rita, Chehín, Rosana
Published in Scientific reports (20.11.2020)
Published in Scientific reports (20.11.2020)
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Microglial glutamate release evoked by α‐synuclein aggregates is prevented by dopamine
dos‐Santos‐Pereira, Mauricio, Acuña, Leonardo, Hamadat, Sabah, Rocca, Jeremy, González‐Lizárraga, Florencia, Chehín, Rosana, Sepulveda‐Diaz, Julia, Del‐Bel, Elaine, Raisman‐Vozari, Rita, Michel, Patrick P.
Published in Glia (01.11.2018)
Published in Glia (01.11.2018)
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Exploiting the therapeutic potential of ready-to-use drugs: Repurposing antibiotics against amyloid aggregation in neurodegenerative diseases
Socias, Sergio B, González-Lizárraga, Florencia, Avila, Cesar L, Vera, Cecilia, Acuña, Leonardo, Sepulveda-Diaz, Julia E, Del-Bel, Elaine, Raisman-Vozari, Rita, Chehin, Rosana N
Published in Progress in neurobiology (01.03.2018)
Published in Progress in neurobiology (01.03.2018)
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C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration
Rose, Clémence, Tomas‐Grau, Rodrigo Hernán, Zabala, Brenda, Michel, Patrick Pierre, Brunel, Jean‐Michel, Chehín, Rosana, Raisman‐Vozari, Rita, Ferrié, Laurent, Figadère, Bruno
Published in ChemMedChem (17.06.2024)
Published in ChemMedChem (17.06.2024)
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Towards efficient biocatalysts: photo-immobilization of a lipase on novel lysozyme amyloid-like nanofibrils
Chaves, Silvina, Pera, Licia M., Avila, Cesar Luis, Romero, Cintia M., Baigori, Mario, Morán Vieyra, F. Eduardo, Borsarelli, Claudio D., Chehin, Rosana N.
Published in RSC advances (2016)
Published in RSC advances (2016)
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Rescue of Dopamine Neurons from Iron-Dependent Ferroptosis by Doxycycline and Demeclocycline and Their Non-Antibiotic Derivatives
Tourville, Aurore, Viguier, Sarah, González-Lizárraga, Florencia, Tomas-Grau, Rodrigo Hernán, Ramirez, Paola, Brunel, Jean-Michel, Dos Santos Pereira, Mauricio, Del-Bel, Elaine, Chehin, Rosana, Ferrié, Laurent, Raisman-Vozari, Rita, Figadère, Bruno, Michel, Patrick Pierre
Published in Antioxidants (24.02.2023)
Published in Antioxidants (24.02.2023)
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The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress
Ferreira Junior, Nilson Carlos, dos Santos Pereira, Maurício, Francis, Nour, Ramirez, Paola, Martorell, Paula, González-Lizarraga, Florencia, Figadère, Bruno, Chehin, Rosana, Del Bel, Elaine, Raisman-Vozari, Rita, Michel, Patrick Pierre
Published in Cells (Basel, Switzerland) (22.08.2021)
Published in Cells (Basel, Switzerland) (22.08.2021)
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Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo
Dominguez-Meijide, Antonio, Parrales, Valeria, Vasili, Eftychia, González-Lizárraga, Florencia, König, Annekatrin, Lázaro, Diana F., Lannuzel, Annie, Haik, Stéphane, Del Bel, Elaine, Chehín, Rosana, Raisman-Vozari, Rita, Michel, Patrick P., Bizat, Nicolas, Outeiro, Tiago Fleming
Published in Neurobiology of disease (01.04.2021)
Published in Neurobiology of disease (01.04.2021)
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Maintenance and thermal stabilization of NADH dehydrogenase-2 conformation upon elimination of its C-terminal region
Villegas, Josefina María, Torres-Bugeau, Clarisa María, Chehín, Rosana, Burgos, Martha Inés, Fidelio, Gerardo Daniel, Rintoul, María Regina, Rapisarda, Viviana Andrea
Published in Biochimie (01.02.2013)
Published in Biochimie (01.02.2013)
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Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates
Acuña, Leonardo, Hamadat, Sabah, Corbalán, Natalia S, González-Lizárraga, Florencia, Dos-Santos-Pereira, Mauricio, Rocca, Jérémy, Díaz, Julia Sepúlveda, Del-Bel, Elaine, Papy-García, Dulce, Chehín, Rosana N, Michel, Patrick P, Raisman-Vozari, Rita
Published in Cells (Basel, Switzerland) (25.07.2019)
Published in Cells (Basel, Switzerland) (25.07.2019)
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Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species
González-Lizárraga, Florencia, Socías, Sergio B., Ávila, César L., Torres-Bugeau, Clarisa M., Barbosa, Leandro R. S., Binolfi, Andres, Sepúlveda-Díaz, Julia E., Del-Bel, Elaine, Fernandez, Claudio O., Papy-Garcia, Dulce, Itri, Rosangela, Raisman-Vozari, Rita, Chehín, Rosana N.
Published in Scientific reports (03.02.2017)
Published in Scientific reports (03.02.2017)
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Design, Synthesis, and Evaluation of a Novel Conjugate Molecule with Dopaminergic and Neuroprotective Activities for Parkinson’s Disease
Ploper, Diego, Pernicone, Agustín O., Tomas-Grau, Rodrigo H., Manzano, Verónica E., Socías, Sergio B., Teran, María del Milagro, Budeguer Isa, Valentina, Sosa-Padilla, Bernardo, González-Lizárraga, Florencia, Avila, César L., Guayán, María Laura, Chaves, Silvina, Cruz, Hernán, Vera Pingitore, Esteban, Varela, Oscar, Chehín, Rosana
Published in ACS chemical neuroscience (07.08.2024)
Published in ACS chemical neuroscience (07.08.2024)
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Role of electrostatics on membrane binding, aggregation and destabilization induced by NAD(P)H dehydrogenases. Implication in membrane fusion
Avila, César L., de Arcuri, Beatriz F., Gonzalez-Nilo, Fernando, De Las Rivas, Javier, Chehín, Rosana, Morero, Roberto
Published in Biophysical chemistry (01.10.2008)
Published in Biophysical chemistry (01.10.2008)
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Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity
Medina, Luciana, González-Lizárraga, Florencia, Dominguez-Meijide, Antonio, Ploper, Diego, Parrales, Valeria, Sequeira, Sabrina, Cima-Omori, Maria-Sol, Zweckstetter, Markus, Del Bel, Elaine, Michel, Patrick P, Outeiro, Tiago Fleming, Raisman-Vozari, Rita, Chehín, Rosana, Socias, Sergio B
Published in Frontiers in aging neuroscience (22.03.2021)
Published in Frontiers in aging neuroscience (22.03.2021)
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Structural Characterization of Heparin-induced Glyceraldehyde-3-phosphate Dehydrogenase Protofibrils Preventing α-Synuclein Oligomeric Species Toxicity
Ávila, César L., Torres-Bugeau, Clarisa M., Barbosa, Leandro R.S., Sales, Elisa Morandé, Ouidja, Mohand O., Socías, Sergio B., Celej, M. Soledad, Raisman-Vozari, Rita, Papy-Garcia, Dulce, Itri, Rosangela, Chehín, Rosana N.
Published in The Journal of biological chemistry (16.05.2014)
Published in The Journal of biological chemistry (16.05.2014)
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