Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion
Scarneo, Scott A., Mansourati, Antoine, Eibschutz, Liesl S., Totzke, Juliane, Roques, Jose R., Loiselle, David, Carlson, David, Hughes, Philip, Haystead, Timothy A. J.
Published in Scientific reports (19.11.2018)
Published in Scientific reports (19.11.2018)
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Minibeam radiation therapy enhanced tumor delivery of PEGylated liposomal doxorubicin in a triple-negative breast cancer mouse model
Price, Lauren S.L., Rivera, Judith N., Madden, Andrew J., Herity, Leah B., Piscitelli, Joseph A., Mageau, Savannah, Santos, Charlene M., Roques, Jose R., Midkiff, Bentley, Feinberg, Nana N., Darr, David, Chang, Sha X., Zamboni, William C.
Published in Therapeutic advances in medical oncology (2021)
Published in Therapeutic advances in medical oncology (2021)
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Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy
Bhatt, Aadra P., Pellock, Samuel J., Biernat, Kristen A., Walton, William G., Wallace, Bret D., Creekmore, Benjamin C., Letertre, Marine M., Swann, Jonathan R., Wilson, Ian D., Roques, Jose R., Darr, David B., Bailey, Sean T., Montgomery, Stephanie A., Roach, Jeffrey M., Azcarate-Peril, M. Andrea, Sartor, R. Balfour, Gharaibeh, Raad Z., Bultman, Scott J., Redinbo, Matthew R.
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2020)
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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies
Tarpley, Michael, Oladapo, Helen O., Strepay, Dillon, Caligan, Thomas B., Chdid, Lhoucine, Shehata, Hassan, Roques, Jose R., Thomas, Rhashad, Laudeman, Christopher P., Onyenwoke, Rob U., Darr, David B., Williams, Kevin P.
Published in European journal of pharmaceutical sciences (01.07.2021)
Published in European journal of pharmaceutical sciences (01.07.2021)
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Journal Article
TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades
Scarneo, Scott A., Yang, Kelly W., Roques, Jose R., Dai, Alanna, Eibschutz, Liesl S., Hughes, Philip, Haystead, Timothy A.J.
Published in Oncotarget (26.05.2020)
Published in Oncotarget (26.05.2020)
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Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells
Oladapo, Helen O., Tarpley, Michael, Sauer, Scott J., Addo, Kezia A., Ingram, Shalonda M., Strepay, Dillon, Ehe, Ben K., Chdid, Lhoucine, Trinkler, Michael, Roques, Jose R., Darr, David B., Fleming, Jodie M., Devi, Gayathri R., Williams, Kevin P.
Published in Cancer letters (28.12.2017)
Published in Cancer letters (28.12.2017)
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Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells
Lee, Sang-Ryul, Rutan, Jennifer A, Monteith, Andrew J, Jones, Shannon Z, Kang, Sun Ah, Krum, Kristen N, Kilmon, Michelle A, Roques, Jose R, Wagner, Nikki J, Clarke, Stephen H, Vilen, Barbara J
Published in The Journal of immunology (1950) (15.10.2012)
Published in The Journal of immunology (1950) (15.10.2012)
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Journal Article
Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages
Gilbert, Mileka R, Wagner, Nikki J, Jones, Shannon Z, Wisz, Amanda B, Roques, Jose R, Krum, Kristen N, Lee, Sang-Ryul, Nickeleit, Volker, Hulbert, Chrys, Thomas, James W, Gauld, Stephen B, Vilen, Barbara J
Published in The Journal of immunology (1950) (15.07.2012)
Published in The Journal of immunology (1950) (15.07.2012)
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Abstract A138: Profiling of harmine and select analogs as differential inhibitors of DYRK1A and monoamine oxidase A: Exploring the potential for anti-cancer efficacy and minimizing off-target activity
Shehata, Hassan, Tarpley, Michael, Oladapo, Helen O, Strepay, Dillon, Roques, Jose R, Onyenwoke, Rob U, Darr, David B, Williams, Kevin P
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Abstract 2219: Cancer prevention using a novel fatty acid synthase inhibitor
Spector, Neil L., Haystead, Tim, Zhao, Sumin, Alwarawrah, Yazan, Alcorta, David, Kim, William, Roques, Jose R., Trinkler, Michael, Darr, David B.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 5051: Comparison of microbeam versus conventional broadbeam radiation therapy on tumor delivery enhancement of PEGylated liposomal doxorubicin in a triple negative breast cancer mouse model
Chang, Sha X., Rivera, Judith N., Herity, Leah B., Price, Lauren S., Madden, Andrew J., Roques, Jose R., Santos, Charlene, Darr, David, Zamboni, William C.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Receptor cross-talk spatially restricts pERK during TLR4 stimulation of autoreactive B cells
Lee, Sang-Ryul, Rutan, Jennifer A., Monteith, Andrew J., Jones, Shannon Z., Kang, Sun Ah, Krum, Kristen N., Kilmon, Michelle A., Roques, Jose R., Wagner, Nikki J., Clarke, Stephen H., Vilen, Barbara J.
Published in The Journal of immunology (1950) (14.09.2012)
Published in The Journal of immunology (1950) (14.09.2012)
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Journal Article
1Autoreactive pre-plasma cells break tolerance in the absence of regulation by dendritic cells and macrophages
Gilbert, Mileka R., Wagner, Nikki J., Jones, Shannon Z., Wisz, Amanda B., Roques, Jose R., Krum, Kristen N., Lee, Sang-Ryul, Nickeleit, Volker, Hulbert, Chrys, Thomas, James W., Gauld, Stephen B., Vilen, Barbara J.
Published in The Journal of immunology (1950) (06.06.2012)
Published in The Journal of immunology (1950) (06.06.2012)
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