Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
John, Alison E, Graves, Rebecca H, Pun, K Tao, Vitulli, Giovanni, Forty, Ellen J, Mercer, Paul F, Morrell, Josie L, Barrett, John W, Rogers, Rebecca F, Hafeji, Maryam, Bibby, Lloyd I, Gower, Elaine, Morrison, Valerie S, Man, Yim, Roper, James A, Luckett, Jeni C, Borthwick, Lee A, Barksby, Ben S, Burgoyne, Rachel A, Barnes, Rory, Le, Joelle, Flint, David J, Pyne, Susan, Habgood, Anthony, Organ, Louise A, Joseph, Chitra, Edwards-Pritchard, Rochelle C, Maher, Toby M, Fisher, Andrew J, Gudmann, Natasja Stæhr, Leeming, Diana J, Chambers, Rachel C, Lukey, Pauline T, Marshall, Richard P, Macdonald, Simon J F, Jenkins, R Gisli, Slack, Robert J
Published in Nature communications (16.09.2020)
Published in Nature communications (16.09.2020)
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Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues
Hazell, Georgina G J, Yao, Song T, Roper, James A, Prossnitz, Eric R, O'Carroll, Anne-Marie, Lolait, Stephen J
Published in Journal of endocrinology (01.08.2009)
Published in Journal of endocrinology (01.08.2009)
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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.
Published in Frontiers in immunology (28.08.2023)
Published in Frontiers in immunology (28.08.2023)
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Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
Kim, Henry, Kretz, Louis, Ronin, Céline, Starck, Christina, Roper, James A, Kahl-Knutson, Barbro, Peterson, Kristoffer, Leffler, Hakon, Nilsson, Ulf J, Pedersen, Anders, Zetterberg, Fredrik R, Slack, Robert J
Published in International journal of molecular sciences (01.06.2024)
Published in International journal of molecular sciences (01.06.2024)
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Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1
Roper, James A., Williamson, Rosalind C., Bally, Blandine, Cowell, Christopher A.M., Brooks, Rebecca, Stephens, Phil, Harrison, Andrew J., Bass, Mark D.
Published in Journal of investigative dermatology (01.11.2015)
Published in Journal of investigative dermatology (01.11.2015)
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Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking
Williamson, Rosalind C., Cowell, Christopher A.M., Reville, Thomas, Roper, James A., Rendall, Thomas C.S., Bass, Mark D.
Published in The Journal of biological chemistry (19.06.2015)
Published in The Journal of biological chemistry (19.06.2015)
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Journal Article
G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis
Hazell, Georgina G.J, Hindmarch, Charles C, Pope, George R, Roper, James A, Lightman, Stafford L, Murphy, David, O’Carroll, Anne-Marie, Lolait, Stephen J
Published in Frontiers in neuroendocrinology (01.01.2012)
Published in Frontiers in neuroendocrinology (01.01.2012)
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Discovery and Optimization of the First Highly Effective and Orally Available Galectin‑3 Inhibitors for Treatment of Fibrotic Disease
Zetterberg, Fredrik R., MacKinnon, Alison, Brimert, Thomas, Gravelle, Lise, Johnsson, Richard E., Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Peterson, Kristoffer, Roper, James A., Schambye, Hans, Slack, Robert J., Tantawi, Susan
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Journal Article
Integrins as a drug target in liver fibrosis
Rahman, Syedia R., Roper, James A., Grove, Jane I., Aithal, Guruprasad P., Pun, K. Tao, Bennett, Andrew J.
Published in Liver international (01.03.2022)
Published in Liver international (01.03.2022)
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Journal Article
Discovery of Selective and Orally Available Galectin‑1 Inhibitors
Zetterberg, Fredrik R., Diehl, Carl, Håkansson, Maria, Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Peterson, Kristoffer, Roper, James A., Slack, Robert J.
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
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Journal Article
Discovery of the Selective and Orally Available Galectin‑1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R., Peterson, Kristoffer, Nilsson, Ulf J., Andréasson Dahlgren, Kajsa, Diehl, Carl, Holyer, Ian, Håkansson, Maria, Khabut, Areej, Kahl-Knutson, Barbro, Leffler, Hakon, MacKinnon, Alison C., Roper, James A., Slack, Robert J., Zarrizi, Reihaneh, Pedersen, Anders
Published in Journal of medicinal chemistry (28.05.2024)
Published in Journal of medicinal chemistry (28.05.2024)
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Journal Article
Syndecan and integrin interactomes: large complexes in small spaces
Roper, James A, Williamson, Rosalind C, Bass, Mark D
Published in Current opinion in structural biology (01.10.2012)
Published in Current opinion in structural biology (01.10.2012)
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Journal Article
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease
Wilkinson, Alex L., John, Alison E., Barrett, John W., Gower, E., Morrison, Valerie S., Man, Yim, Pun, K. Tao, Roper, James A., Luckett, Jeni C., Borthwick, Lee A., Barksby, Ben S., Burgoyne, Rachel A., Barnes, Rory, Fisher, Andrew J., Procopiou, Panayiotis A., Hatley, Richard J.D., Barrett, Tim N., Marshall, Richard P., Macdonald, Simon J.F., Jenkins, R. Gisli, Slack, Robert J.
Published in European journal of pharmacology (15.12.2021)
Published in European journal of pharmacology (15.12.2021)
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Journal Article
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure
Williamson, Rosalind C, Cowell, Christopher A M, Hammond, Christina L, Bergen, Dylan J M, Roper, James A, Feng, Yi, Rendall, Thomas C S, Race, Paul R, Bass, Mark D
Published in Journal of cell science (01.10.2014)
Published in Journal of cell science (01.10.2014)
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Journal Article
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor(3S)‑3-(3-(3,5-Dimethyl‑1H‑pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)‑1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation
Barrett, Tim N, Taylor, Jonathan A, Barker, Daniel, Procopiou, Panayiotis A, Thompson, James D. F, Barrett, John, Le, Joelle, Lynn, Sean M, Pogany, Peter, Pratley, Cassie, Pritchard, John M, Roper, James A, Rowedder, James E, Slack, Robert J, Vitulli, Giovanni, Macdonald, Simon J. F, Kerr, William J
Published in Journal of medicinal chemistry (22.08.2019)
Published in Journal of medicinal chemistry (22.08.2019)
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Journal Article
Profile of a Highly Selective Quaternized Pyrrolidine Betaine α v β 6 Integrin Inhibitor-(3 S )-3-(3-(3,5-Dimethyl-1 H -pyrazol-1-yl)phenyl)-4-((1 S and 1 R ,3 R )-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation
Barrett, Tim N, Taylor, Jonathan A, Barker, Daniel, Procopiou, Panayiotis A, Thompson, James D F, Barrett, John, Le, Joelle, Lynn, Sean M, Pogany, Peter, Pratley, Cassie, Pritchard, John M, Roper, James A, Rowedder, James E, Slack, Robert J, Vitulli, Giovanni, Macdonald, Simon J F, Kerr, William J
Published in Journal of medicinal chemistry (22.08.2019)
Published in Journal of medicinal chemistry (22.08.2019)
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