Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5‑d]azepines as Potent 5‑Hydroxytryptamine 2C (5-HT2C) Receptor Agonists with Exquisite Functional Selectivity over 5‑HT2A and 5‑HT2B Receptors
Storer, R. Ian, Brennan, Paul E, Brown, Alan D, Bungay, Peter J, Conlon, Kelly M, Corbett, Matthew S, DePianta, Robert P, Fish, Paul V, Heifetz, Alexander, Ho, Danny K. H, Jessiman, Alan S, McMurray, Gordon, de Oliveira, Cesar Augusto F, Roberts, Lee R, Root, James A, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Skerten, Melanie, Westbrook, Dominique, Wheeler, Simon, Whitlock, Gavin A, Wright, John
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Journal Article
Pyrimido[4,5-d]azepines as potent and selective 5-HT₂C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence
Andrews, Mark D, Fish, Paul V, Blagg, Julian, Brabham, Tiffini K, Brennan, Paul E, Bridgeland, Alison, Brown, Alan D, Bungay, Peter J, Conlon, Kelly M, Edmunds, Nicholas J, af Forselles, Kerry, Gibbons, Colleen P, Green, Martin P, Hanton, Giles, Holbrook, Mark, Jessiman, Alan S, McIntosh, Karin, McMurray, Gordon, Nichols, Carly L, Root, James A, Storer, R. Ian, Sutton, Michael R, Ward, Robin V, Westbrook, Dominique, Whitlock, Gavin A
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Get full text
Journal Article
Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5- d ]azepines as Potent 5-Hydroxytryptamine 2C (5-HT 2C ) Receptor Agonists with Exquisite Functional Selectivity over 5-HT 2A and 5-HT 2B Receptors
Storer, R. Ian, Brennan, Paul E., Brown, Alan D., Bungay, Peter J., Conlon, Kelly M., Corbett, Matthew S., DePianta, Robert P., Fish, Paul V., Heifetz, Alexander, Ho, Danny K. H., Jessiman, Alan S., McMurray, Gordon, de Oliveira, Cesar Augusto F., Roberts, Lee R., Root, James A., Shanmugasundaram, Veerabahu, Shapiro, Michael J., Skerten, Melanie, Westbrook, Dominique, Wheeler, Simon, Whitlock, Gavin A., Wright, John
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
Get full text
Journal Article
Pyrimido[4,5-d]azepines as potent and selective 5-HT sub(2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence)
Andrews, Mark D, Fish, Paul V, Blagg, Julian, Brabham, Tiffini K, Brennan, Paul E, Bridgeland, Alison, Brown, Alan D, Bungay, Peter J, Conlon, Kelly M, Edmunds, Nicholas J, selles, Kerry af, Gibbons, Colleen P, Green, Martin P, Hanton, Giles, Holbrook, Mark, Jessiman, Alan S, McIntosh, Karin, McMurray, Gordon, Nichols, Carly L, Root, James A, Storer, RIan, Sutton, Michael R, Ward, Robin V, Westbrook, Dominique, Whitlock, Gavin A
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Get full text
Journal Article
Pyrimido[4,5- d]azepines as potent and selective 5-HT 2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence
Andrews, Mark D., Fish, Paul V., Blagg, Julian, Brabham, Tiffini K., Brennan, Paul E., Bridgeland, Alison, Brown, Alan D., Bungay, Peter J., Conlon, Kelly M., Edmunds, Nicholas J., af Forselles, Kerry, Gibbons, Colleen P., Green, Martin P., Hanton, Giles, Holbrook, Mark, Jessiman, Alan S., McIntosh, Karin, McMurray, Gordon, Nichols, Carly L., Root, James A., Storer, R. Ian, Sutton, Michael R., Ward, Robin V., Westbrook, Dominique, Whitlock, Gavin A.
Published in Bioorganic & medicinal chemistry letters (2011)
Published in Bioorganic & medicinal chemistry letters (2011)
Get full text
Journal Article