Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
Lim, Junghyun, Park, Hyunjoo, Heisler, Jason, Maculins, Timurs, Roose-Girma, Merone, Xu, Min, Mckenzie, Brent, van Lookeren Campagne, Menno, Newton, Kim, Murthy, Aditya
Published in eLife (09.07.2019)
Published in eLife (09.07.2019)
Get full text
Journal Article
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1
He, Meng, Chaurushiya, Mira S, Webster, Joshua D, Kummerfeld, Sarah, Reja, Rohit, Chaudhuri, Subhra, Chen, Ying-Jiun, Modrusan, Zora, Haley, Benjamin, Dugger, Debra L, Eastham-Anderson, Jeffrey, Lau, Shari, Dey, Anwesha, Caothien, Roger, Roose-Girma, Merone, Newton, Kim, Dixit, Vishva M
Published in Science (American Association for the Advancement of Science) (19.04.2019)
Published in Science (American Association for the Advancement of Science) (19.04.2019)
Get full text
Journal Article
BMP1 is not required for lung fibrosis in mice
Ma, Hsiao-Yen, N’Diaye, Elsa-Noah, Caplazi, Patrick, Huang, Zhiyu, Arlantico, Alexander, Jeet, Surinder, Wong, Aaron, Brightbill, Hans D., Li, Qingling, Wong, Weng Ruth, Sandoval, Wendy, Tam, Lucinda, Newman, Robert, Roose-Girma, Merone, Ding, Ning
Published in Scientific reports (31.03.2022)
Published in Scientific reports (31.03.2022)
Get full text
Journal Article
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
Whiteley, Alexandra M, Prado, Miguel A, Peng, Ivan, Abbas, Alexander R, Haley, Benjamin, Paulo, Joao A, Reichelt, Mike, Katakam, Anand, Sagolla, Meredith, Modrusan, Zora, Lee, Dong Yun, Roose-Girma, Merone, Kirkpatrick, Donald S, McKenzie, Brent S, Gygi, Steven P, Finley, Daniel, Brown, Eric J
Published in eLife (21.09.2017)
Published in eLife (21.09.2017)
Get full text
Journal Article
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Newton, Kim, Wickliffe, Katherine E., Dugger, Debra L., Maltzman, Allie, Roose-Girma, Merone, Dohse, Monika, Kőműves, László, Webster, Joshua D., Dixit, Vishva M.
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
Get full text
Journal Article
Activity of caspase-8 determines plasticity between cell death pathways
Newton, Kim, Wickliffe, Katherine E., Maltzman, Allie, Dugger, Debra L., Reja, Rohit, Zhang, Yue, Roose-Girma, Merone, Modrusan, Zora, Sagolla, Meredith S., Webster, Joshua D., Dixit, Vishva M.
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
Get full text
Journal Article
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
Zhou, Yi, Fei, Mingjian, Zhang, Gu, Liang, Wei-Ching, Lin, WeiYu, Wu, Yan, Piskol, Robert, Ridgway, John, McNamara, Erin, Huang, Haochu, Zhang, Juan, Oh, Jaehak, Patel, Jaina M., Jakubiak, Diana, Lau, Jeff, Blackwood, Beth, Bravo, Daniel D., Shi, Yongchang, Wang, Jianyong, Hu, Hong-Ming, Lee, Wyne P., Jesudason, Rajiv, Sangaraju, Dewakar, Modrusan, Zora, Anderson, Keith R., Warming, Søren, Roose-Girma, Merone, Yan, Minhong
Published in Immunity (Cambridge, Mass.) (18.02.2020)
Published in Immunity (Cambridge, Mass.) (18.02.2020)
Get full text
Journal Article
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury
Chung, Jun-Jae, Goldstein, Leonard, Chen, Ying-Jiun J, Lee, Jiyeon, Webster, Joshua D, Roose-Girma, Merone, Paudyal, Sharad C, Modrusan, Zora, Dey, Anwesha, Shaw, Andrey S
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
Get full text
Journal Article
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
Lee, Bettina L, Stowe, Irma B, Gupta, Aaron, Kornfeld, Opher S, Roose-Girma, Merone, Anderson, Keith, Warming, Søren, Zhang, Juan, Lee, Wyne P, Kayagaki, Nobuhiko
Published in The Journal of experimental medicine (03.09.2018)
Published in The Journal of experimental medicine (03.09.2018)
Get full text
Journal Article
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death
Kist, Matthias, Kőműves, László G., Goncharov, Tatiana, Dugger, Debra L., Yu, Charles, Roose-Girma, Merone, Newton, Kim, Webster, Joshua D., Vucic, Domagoj
Published in Cell death and differentiation (01.03.2021)
Published in Cell death and differentiation (01.03.2021)
Get full text
Journal Article
A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3
Murthy, Aditya, Li, Yun, Peng, Ivan, Reichelt, Mike, Katakam, Anand Kumar, Noubade, Rajkumar, Roose-Girma, Merone, DeVoss, Jason, Diehl, Lauri, Graham, Robert R., van Lookeren Campagne, Menno
Published in Nature (London) (27.02.2014)
Published in Nature (London) (27.02.2014)
Get full text
Journal Article
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
Meunier, Etienne, Dick, Mathias S., Dreier, Roland F., Schürmann, Nura, Broz, Daniela Kenzelmann, Warming, Søren, Roose-Girma, Merone, Bumann, Dirk, Kayagaki, Nobuhiko, Takeda, Kiyoshi, Yamamoto, Masahiro, Broz, Petr
Published in Nature (London) (15.05.2014)
Published in Nature (London) (15.05.2014)
Get full text
Journal Article
Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
Newton, Kim, Dugger, Debra L., Wickliffe, Katherine E., Kapoor, Neeraj, de Almagro, M. Cristina, Vucic, Domagoj, Komuves, Laszlo, Ferrando, Ronald E., French, Dorothy M., Webster, Joshua, Roose-Girma, Merone, Warming, Søren, Dixit, Vishva M.
Published in Science (American Association for the Advancement of Science) (21.03.2014)
Published in Science (American Association for the Advancement of Science) (21.03.2014)
Get full text
Journal Article
CRISPR off-target analysis in genetically engineered rats and mice
Anderson, Keith R., Haeussler, Maximilian, Watanabe, Colin, Janakiraman, Vasantharajan, Lund, Jessica, Modrusan, Zora, Stinson, Jeremy, Bei, Qixin, Buechler, Andrew, Yu, Charles, Thamminana, Sobha R., Tam, Lucinda, Sowick, Michael-Anne, Alcantar, Tuija, O’Neil, Natasha, Li, Jinjie, Ta, Linda, Lima, Lisa, Roose-Girma, Merone, Rairdan, Xin, Durinck, Steffen, Warming, Søren
Published in Nature methods (01.07.2018)
Published in Nature methods (01.07.2018)
Get full text
Journal Article
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly
He, Feng, Antonucci, Laura, Yamachika, Shinichiro, Zhang, Zechuan, Taniguchi, Koji, Umemura, Atsushi, Hatzivassiliou, Georgia, Roose-Girma, Merone, Reina-Campos, Miguel, Duran, Angeles, Diaz-Meco, Maria T., Moscat, Jorge, Sun, Beicheng, Karin, Michael
Published in Journal of hepatology (01.06.2020)
Published in Journal of hepatology (01.06.2020)
Get full text
Journal Article
IRF2 transcriptionally induces GSDMD expression for pyroptosis
Kayagaki, Nobuhiko, Lee, Bettina L, Stowe, Irma B, Kornfeld, Opher S, O'Rourke, Karen, Mirrashidi, Kathleen M, Haley, Benjamin, Watanabe, Colin, Roose-Girma, Merone, Modrusan, Zora, Kummerfeld, Sarah, Reja, Rohit, Zhang, Yafei, Cho, Vicky, Andrews, T Daniel, Morris, Lucy X, Goodnow, Christopher C, Bertram, Edward M, Dixit, Vishva M
Published in Science signaling (21.05.2019)
Published in Science signaling (21.05.2019)
Get more information
Journal Article
OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Heger, Klaus, Wickliffe, Katherine E., Ndoja, Ada, Zhang, Juan, Murthy, Aditya, Dugger, Debra L., Maltzman, Allie, de Sousa e Melo, Felipe, Hung, Jeffrey, Zeng, Yi, Verschueren, Erik, Kirkpatrick, Donald S., Vucic, Domagoj, Lee, Wyne P., Roose-Girma, Merone, Newman, Robert J., Warming, Søren, Hsiao, Yi-Chun, Kőműves, László G., Webster, Joshua D., Newton, Kim, Dixit, Vishva M.
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
Get full text
Journal Article
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues
Kapoor, Varun N., Müller, Sören, Keerthivasan, Shilpa, Brown, Markus, Chalouni, Cecile, Storm, Elaine E., Castiglioni, Alessandra, Lane, Ryan, Nitschke, Maximilian, Dominguez, Claudia X., Astarita, Jillian L., Krishnamurty, Akshay T., Carbone, Catherine B., Senbabaoglu, Yasin, Wang, Amber W., Wu, Xiumin, Cremasco, Viviana, Roose-Girma, Merone, Tam, Lucinda, Doerr, Jonas, Chen, Mark Z., Lee, Wyne P., Modrusan, Zora, Yang, Yeqing Angela, Bourgon, Richard, Sandoval, Wendy, Shaw, Andrey S., de Sauvage, Frederic J., Mellman, Ira, Moussion, Christine, Turley, Shannon J.
Published in Nature immunology (01.05.2021)
Published in Nature immunology (01.05.2021)
Get full text
Journal Article
Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation
Zhang, Jieqiong, Webster, Joshua D., Dugger, Debra L., Goncharov, Tatiana, Roose-Girma, Merone, Hung, Jeffrey, Kwon, Youngsu C., Vucic, Domagoj, Newton, Kim, Dixit, Vishva M.
Published in Cell reports (Cambridge) (28.05.2019)
Published in Cell reports (Cambridge) (28.05.2019)
Get full text
Journal Article
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
Barreira da Silva, Rosa, Leitao, Ricardo M., Pechuan-Jorge, Ximo, Werneke, Scott, Oeh, Jason, Javinal, Vincent, Wang, Yingyun, Phung, Wilson, Everett, Christine, Nonomiya, Jim, Arnott, David, Lu, Cheng, Hsiao, Yi-Chun, Koerber, James T., Hötzel, Isidro, Ziai, James, Modrusan, Zora, Pillow, Thomas H., Roose-Girma, Merone, Schartner, Jill M., Merchant, Mark, Rutz, Sascha, Eidenschenk, Céline, Mellman, Ira, Albert, Matthew L.
Published in Nature immunology (01.04.2022)
Published in Nature immunology (01.04.2022)
Get full text
Journal Article