The Potent Oxidant Anticancer Activity of Organoiridium Catalysts
Liu, Zhe, Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J., Sadler, Peter J.
Published in Angewandte Chemie (International ed.) (07.04.2014)
Published in Angewandte Chemie (International ed.) (07.04.2014)
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Journal Article
The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway
Romero-Canelón, Isolda, Salassa, Luca, Sadler, Peter J
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Journal Article
Towards Identification of Essential Structural Elements of Organoruthenium(II)‐Pyrithionato Complexes for Anticancer Activity
Kladnik, Jerneja, Kljun, Jakob, Burmeister, Hilke, Ott, Ingo, Romero‐Canelón, Isolda, Turel, Iztok
Published in Chemistry : a European journal (07.11.2019)
Published in Chemistry : a European journal (07.11.2019)
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Journal Article
In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes
Needham, Russell J., Sanchez‐Cano, Carlos, Zhang, Xin, Romero‐Canelón, Isolda, Habtemariam, Abraha, Cooper, Margaret S., Meszaros, Levente, Clarkson, Guy J., Blower, Philip J., Sadler, Peter J.
Published in Angewandte Chemie International Edition (19.01.2017)
Published in Angewandte Chemie International Edition (19.01.2017)
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Journal Article
Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation
Romero-Canelón, Isolda, Mos, Magdalena, Sadler, Peter J.
Published in Journal of medicinal chemistry (08.10.2015)
Published in Journal of medicinal chemistry (08.10.2015)
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Journal Article
Synchrotron X‐Ray Fluorescence Nanoprobe Reveals Target Sites for Organo‐Osmium Complex in Human Ovarian Cancer Cells
Sanchez‐Cano, Carlos, Romero‐Canelón, Isolda, Yang, Yang, Hands‐Portman, Ian J., Bohic, Sylvain, Cloetens, Peter, Sadler, Peter J.
Published in Chemistry : a European journal (21.02.2017)
Published in Chemistry : a European journal (21.02.2017)
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Journal Article
Designing Ruthenium Anticancer Drugs: What Have We Learnt from the Key Drug Candidates?
Coverdale, James, Laroiya-McCarron, Thaisa, Romero-Canelón, Isolda
Published in Inorganics (01.03.2019)
Published in Inorganics (01.03.2019)
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Journal Article
Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells
Hearn, Jessica M, Isolda Romero-CaneloÌn, Alison F. Munro, Ying Fu, Ana M. Pizarro, Mathew J. Garnett, Ultan McDermott, Neil O. Carragher, Peter J. Sadler
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2015)
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Journal Article
Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity
Gatti, Anna, Habtemariam, Abraha, Romero-Canelón, Isolda, Song, Ji-Inn, Heer, Bindy, Clarkson, Guy J, Rogolino, Dominga, Sadler, Peter J, Carcelli, Mauro
Published in Organometallics (26.03.2018)
Published in Organometallics (26.03.2018)
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Journal Article
Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism
Nakou, Ioanna T., Jenner, Matthew, Dashti, Yousef, Romero‐Canelón, Isolda, Masschelein, Joleen, Mahenthiralingam, Eshwar, Challis, Gregory L.
Published in Angewandte Chemie International Edition (14.12.2020)
Published in Angewandte Chemie International Edition (14.12.2020)
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Journal Article
Supramolecular Photoactivatable Anticancer Hydrogels
Venkatesh, V, Mishra, Narendra Kumar, Romero-Canelón, Isolda, Vernooij, Robbin R, Shi, Huayun, Coverdale, James P. C, Habtemariam, Abraha, Verma, Sandeep, Sadler, Peter J
Published in Journal of the American Chemical Society (26.04.2017)
Published in Journal of the American Chemical Society (26.04.2017)
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Journal Article
Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis
Hearn, Jessica M, Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe, Hands-Portman, Ian, Sadler, Peter J
Published in ACS chemical biology (21.06.2013)
Published in ACS chemical biology (21.06.2013)
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Journal Article
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance
Chellan, Prinessa, Avery, Vicky M., Duffy, Sandra, Triccas, James A., Nagalingam, Gayathri, Tam, Christina, Cheng, Luisa W., Liu, Jenny, Land, Kirkwood M., Clarkson, Guy J., Romero‐Canelón, Isolda, Sadler, Peter J.
Published in Chemistry : a European journal (17.07.2018)
Published in Chemistry : a European journal (17.07.2018)
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Journal Article
Effect of Regiochemistry and Methylation on the Anticancer Activity of a Ferrocene‐Containing Organometallic Nucleoside Analogue
Ismail, Media K., Khan, Zahra, Rana, Marium, Horswell, Sarah L., Male, Louise, Nguyen, Huy V., Perotti, Alessio, Romero‐Canelón, Isolda, Wilkinson, Edward A., Hodges, Nikolas J., Tucker, James H. R.
Published in Chembiochem : a European journal of chemical biology (01.09.2020)
Published in Chembiochem : a European journal of chemical biology (01.09.2020)
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Journal Article
Systems approach to metal-based pharmacology
Romero-Canelón, Isolda, Sadler, Peter J.
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
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Journal Article
Cyclic Peptide–Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes
Larnaudie, Sophie C, Brendel, Johannes C, Romero-Canelón, Isolda, Sanchez-Cano, Carlos, Catrouillet, Sylvain, Sanchis, Joaquin, Coverdale, James P. C, Song, Ji-Inn, Habtemariam, Abraha, Sadler, Peter J, Jolliffe, Katrina A, Perrier, Sébastien
Published in Biomacromolecules (08.01.2018)
Published in Biomacromolecules (08.01.2018)
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Journal Article
In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
Coverdale, James P. C, Bridgewater, Hannah E, Song, Ji-Inn, Smith, Nichola A, Barry, Nicolas P. E, Bagley, Ian, Sadler, Peter J, Romero-Canelón, Isolda
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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Journal Article