Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi
Varela, Marina T., Amaral, Maiara, Romanelli, Maiara M., de Castro Levatti, Erica V., Tempone, Andre G., Fernandes, João Paulo S.
Published in European journal of pharmaceutical sciences (01.04.2022)
Published in European journal of pharmaceutical sciences (01.04.2022)
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Antileishmanial Effects of Acetylene Acetogenins from Seeds of Porcelia macrocarpa (Warm.) R.E. Fries (Annonaceae) and Semisynthetic Derivatives
Brito, Ivanildo A, Thevenard, Fernanda, Costa-Silva, Thais A, Oliveira, Samuel S, Cunha, Rodrigo L O R, de Oliveira, Emerson A, Sartorelli, Patricia, Guadagnin, Rafael C, Romanelli, Maiara M, Tempone, Andre G, Lago, João Henrique G
Published in Molecules (Basel, Switzerland) (28.01.2022)
Published in Molecules (Basel, Switzerland) (28.01.2022)
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Selective Activity Against Amastigote Forms of Trypanosoma cruzi and Leishmania infantum of Diastereomeric Dicentrine N-oxides
Tristão, Daniela C, Barbosa, Henrique, de Castro Levatti, Erica V, Andrade, Beatriz A, Romanelli, Maiara M, Antar, Guilherme M, Tempone, Andre G, Lago, João Henrique G
Published in Chemistry & biodiversity (19.06.2024)
Published in Chemistry & biodiversity (19.06.2024)
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Journal Article
Calanolides E1 and E2, two related coumarins from Calophyllum brasiliense Cambess. (Clusiaceae), displayed in vitro activity against amastigote forms of Trypanosoma cruzi and Leishmania infantum
Silva, Luciana Grus, Gomes, Kaio S., Costa-Silva, Thais A., Romanelli, Maiara M., Tempone, Andre G., Sartorelli, Patricia, Lago, João Henrique G.
Published in Natural product research (02.12.2021)
Published in Natural product research (02.12.2021)
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Journal Article
Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity
Varela, Marina T., Romanelli, Maiara, Amaral, Maiara, Tempone, Andre G., Fernandes, João Paulo S.
Published in Saudi pharmaceutical journal (01.07.2023)
Published in Saudi pharmaceutical journal (01.07.2023)
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Journal Article
Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa)
Lima, Marta L., Romanelli, Maiara M., Borborema, Samanta E.T., Johns, Deidre M., Migotto, Alvaro Esteves, Lago, João Henrique G., Tempone, Andre G.
Published in Bioorganic chemistry (01.08.2019)
Published in Bioorganic chemistry (01.08.2019)
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Dereplication of Aporphine Alkaloids by UHPLC-HR-ESI-MS/MS and NMR from Duguetia lanceolata St.-Hil (Annonaceae) and Antiparasitic Activity Evaluation
Dantas, Erick, Monteiro, Jackson, de Medeiros, Lívia, Romanelli, Maiara, Amaral, Maiara, Tempone, Andre, Lago, João Henrique, Soares, Marisi, Sartorelli, Patricia
Published in Journal of the Brazilian Chemical Society (01.09.2020)
Published in Journal of the Brazilian Chemical Society (01.09.2020)
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Journal Article
Mitochondrial Imbalance of Trypanosoma cruzi Induced by the Marine Alkaloid 6‑Bromo-2′-de‑N‑Methylaplysinopsin
Romanelli, Maiara M., Amaral, Maiara, Thevenard, Fernanda, Santa Cruz, Lucas M., Regasini, Luis O., Migotto, Alvaro E., Lago, João Henrique G., Tempone, Andre G.
Published in ACS omega (16.08.2022)
Published in ACS omega (16.08.2022)
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Journal Article
Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi
Sear, Claire E, Pieper, Pauline, Amaral, Maiara, Romanelli, Maiara M, Costa-Silva, Thais A, Haugland, Marius M, Tate, Joseph A, Lago, João H. G, Tempone, Andre G, Anderson, Edward A
Published in ACS infectious diseases (13.11.2020)
Published in ACS infectious diseases (13.11.2020)
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Journal Article
Sertraline Delivered in Phosphatidylserine Liposomes Is Effective in an Experimental Model of Visceral Leishmaniasis
Romanelli, Maiara Maria, da Costa-Silva, Thais Alves, Cunha-Junior, Edezio, Dias Ferreira, Daiane, Guerra, Juliana M, Galisteo, Jr, Andres Jimenez, Pinto, Erika Gracielle, Barbosa, Leandro R S, Torres-Santos, Eduardo Caio, Tempone, Andre Gustavo
Published in Frontiers in cellular and infection microbiology (29.10.2019)
Published in Frontiers in cellular and infection microbiology (29.10.2019)
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Journal Article
Efficacy of sertraline against Trypanosoma cruzi : an in vitro and in silico study
Ferreira, Daiane Dias, Mesquita, Juliana Tonini, da Costa Silva, Thais Alves, Romanelli, Maiara Maria, da Gama Jaen Batista, Denise, da Silva, Cristiane França, da Gama, Aline Nefertiti Silva, Neves, Bruno Junior, Melo-Filho, Cleber Camilo, Correia Soeiro, Maria de Nazare, Andrade, Carolina Horta, Tempone, Andre Gustavo
Published in The journal of venomous animals and toxins including tropical diseases (30.10.2018)
Published in The journal of venomous animals and toxins including tropical diseases (30.10.2018)
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A new reduced chalcone-derivative affects the membrane permeability and electric potential of multidrug-resistant Enterococcusfaecalis
Tempone, Andre Gustavo, Theodoro, Reinaldo dos Santos, Romanelli, Maiara Maria, Santos Ferreira, Dayana Agnes, Amaral, Maiara, Ribeiro de Assis, Leticia, Santa Cruz, Lucas Monteiro, Costa, Alan Roberto, Zanella, Rosemeire Cobo, Christodoulides, Myron, Regasini, Luis Octavio, Camargo, Carlos Henrique
Published in Chemico-biological interactions (25.09.2022)
Published in Chemico-biological interactions (25.09.2022)
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Journal Article
A new reduced chalcone-derivative affects the membrane permeability and electric potential of multidrug-resistant Enterococcus faecalis
Tempone, Andre Gustavo, Theodoro, Reinaldo dos Santos, Romanelli, Maiara Maria, Santos Ferreira, Dayana Agnes, Amaral, Maiara, Ribeiro de Assis, Leticia, Santa Cruz, Lucas Monteiro, Costa, Alan Roberto, Zanella, Rosemeire Cobo, Christodoulides, Myron, Regasini, Luis Octavio, Camargo, Carlos Henrique
Published in Chemico-biological interactions (25.09.2022)
Published in Chemico-biological interactions (25.09.2022)
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Journal Article
In Vitro and In Silico Evaluation of the Leishmanicidal and Trypanocidal Activities of Lignan Methylpiperitol Isolated from Persea Fulva
Alves Reis, Isabella Mary, Silva, Girliane Regina, Mattos Oliveira, Larissa, Coelho dos Santos Junior, Manoelito, Sarmento da Silva, Tania Maria, Curcino Vieira, Ivo José, Braz‐Filho, Raimundo, Romanelli, Maiara Maria, Amaral, Maiara, Tempone, Andre Gustavo, Ghilardi Lago, João Henrique, Branco, Alexsandro
Published in Chemistry & biodiversity (01.08.2024)
Published in Chemistry & biodiversity (01.08.2024)
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Journal Article
Repurposing topical triclosan for cutaneous leishmaniasis: Preclinical efficacy in a murine Leishmania (L.) amazonensis model
Mesquita, Juliana Tonini, Romanelli, Maiara Maria, de Melo Trinconi Trinconi CM, Cristiana, Guerra, Juliana Mariotti, Taniwaki, Noemi Nosomi, Uliana, Silvia Reni Bortolin, Reimão, Juliana Quero, Tempone, Andre Gustavo
Published in Drug development research (01.04.2022)
Published in Drug development research (01.04.2022)
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Journal Article
Antitrypanosomal Activity of Acetogenins Isolated from the Seeds of Porcelia macrocarpa Is Associated with Alterations in Both Plasma Membrane Electric Potential and Mitochondrial Membrane Potential
Oliveira, Emerson A, Brito, Ivanildo A, Lima, Marta L, Romanelli, Maiara, Moreira-Filho, José T, Neves, Bruno J, Andrade, Carolina H, Sartorelli, Patricia, Tempone, Andre G, Costa-Silva, Thais A, Lago, João Henrique G
Published in Journal of natural products (Washington, D.C.) (24.05.2019)
Published in Journal of natural products (Washington, D.C.) (24.05.2019)
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Journal Article
Hedyosulide, a novel trypanosomicidal sesterterpene lactone from Hedyosmum brasiliense Mart. ex Miq
Murakami, Cynthia, Cabral, Rodrigo Sant’Ana, Gomes, Kaio S., Costa-Silva, Thais A., Amaral, Maiara, Romanelli, Maiara, Tempone, Andre G., Lago, João Henrique G., da S. Bolzani, Vanderlan, Moreno, Paulo Roberto H., Young, Maria Cláudia M.
Published in Phytochemistry letters (01.10.2019)
Published in Phytochemistry letters (01.10.2019)
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