In Vitro Simulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled Capsules and Loose Pellets
Staniszewska, Marcela, Myslitska, Daria, Romański, Michał, Polak, Sebastian, Garbacz, Grzegorz, Dobosz, Justyna, Smoleński, Michał, Paszkowska, Jadwiga, Danielak, Dorota
Published in Molecular pharmaceutics (06.05.2024)
Published in Molecular pharmaceutics (06.05.2024)
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Journal Article
Drug dissolution and transit in a heterogenous gastric chyme after fed administration: Semi-mechanistic modeling and simulations for an immediate-release and orodispersible tablets containing a poorly soluble drug
Danielak, Dorota, Gajda, Maciej, Bołtromiuk, Tomasz, Sulikowska, Katarzyna, Kubiak, Bartłomiej, Romański, Michał
Published in European journal of pharmaceutics and biopharmaceutics (01.07.2024)
Published in European journal of pharmaceutics and biopharmaceutics (01.07.2024)
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Journal Article
More Than a Gut FeelingA Combination of Physiologically Driven Dissolution and Pharmacokinetic Modeling as a Tool for Understanding Human Gastric Motility
Romański, Michał, Staniszewska, Marcela, Dobosz, Justyna, Myslitska, Daria, Paszkowska, Jadwiga, Kołodziej, Bartosz, Romanova, Svitlana, Banach, Grzegorz, Garbacz, Grzegorz, Sarcevica, Inese, Huh, Yeamin, Purohit, Vivek, McAllister, Mark, Wong, Suet M., Danielak, Dorota
Published in Molecular pharmaceutics (05.08.2024)
Published in Molecular pharmaceutics (05.08.2024)
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Journal Article
Conjunction of semi-mechanistic in vitro-in vivo modeling and population pharmacokinetics as a tool for virtual bioequivalence analysis - a case study for a BCS class II drug
Danielak, Dorota, Paszkowska, Jadwiga, Staniszewska, Marcela, Garbacz, Grzegorz, Terlecka, Anna, Kubiak, Bartłomiej, Romański, Michał
Published in European journal of pharmaceutics and biopharmaceutics (01.05.2023)
Published in European journal of pharmaceutics and biopharmaceutics (01.05.2023)
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Journal Article
Kinetics of in Vitro Guanine‑N7‑Alkylation in Calf Thymus DNA by (2S,3S)‑1,2-Epoxybutane-3,4-diol 4‑methanesulfonate and (2S,3S)‑1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-Linking by the Prodrug Treosulfan
Romański, Michał, Pogorzelska, Alicja, Główka, Franciszek K
Published in Molecular pharmaceutics (03.06.2019)
Published in Molecular pharmaceutics (03.06.2019)
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Journal Article
Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives
Romański, Michał, Wachowiak, Jacek, Główka, Franciszek K.
Published in Clinical pharmacokinetics (01.10.2018)
Published in Clinical pharmacokinetics (01.10.2018)
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Journal Article
PhysioCell — a Novel, Bio-relevant Dissolution Apparatus: Hydrodynamic Conditions and Factors Influencing the Dissolution Dynamics
Staniszewska, Marcela, Romański, Michał, Dobosz, Justyna, Kołodziej, Bartosz, Lipski, Uladzimir, Garbacz, Grzegorz, Danielak, Dorota
Published in AAPS PharmSciTech (14.02.2023)
Published in AAPS PharmSciTech (14.02.2023)
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Journal Article
Application of a novel PhysioCell apparatus for biopredictive dissolution tests of oral immediate release formulations – A case study workflow for in vitro-in vivo predictions
Romański, Michał, Staniszewska, Marcela, Paszkowska, Jadwiga, Dobosz, Justyna, Romanova, Svitlana, Pieczuro, Jarosław, Kątny, Michał, Roznerska, Dagmara, Szczepański, Janusz, Schraube, Michał, Renn-Hojan, Monika, Puk, Ewa, Hrem, Oksana, Garbacz, Grzegorz, Danielak, Dorota
Published in International journal of pharmaceutics (25.06.2023)
Published in International journal of pharmaceutics (25.06.2023)
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Journal Article
Dissolution of a Biopharmaceutics Classification System Class II Free Acid from Immediate Release Tablets Containing a Microenvironmental pH Modulator: Comparison of a Biorelevant Bicarbonate Buffering System with Phosphate Buffers
Haznar-Garbacz, Dorota, Hoc, Dagmara, Garbacz, Grzegorz, Lachman, Marek, Słomińska, Daria, Romański, Michał
Published in AAPS PharmSciTech (26.07.2022)
Published in AAPS PharmSciTech (26.07.2022)
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Journal Article
Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance
Romański, Michał, Kasprzyk, Anna, Walczak, Mateusz, Ziółkowska, Agnieszka, Główka, Franciszek
Published in European journal of pharmaceutical sciences (15.11.2017)
Published in European journal of pharmaceutical sciences (15.11.2017)
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Journal Article
Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model
Danielak, Dorota, Romański, Michał, Kasprzyk, Anna, Teżyk, Artur, Główka, Franciszek
Published in Pharmacological reports (01.10.2020)
Published in Pharmacological reports (01.10.2020)
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Journal Article
A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning
Staniszewska, Marcela, Romański, Michał, Polak, Sebastian, Garbacz, Grzegorz, Dobosz, Justyna, Myslitska, Daria, Romanova, Svitlana, Paszkowska, Jadwiga, Danielak, Dorota
Published in Pharmaceutics (31.07.2023)
Published in Pharmaceutics (31.07.2023)
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Journal Article
N-7-Guanine Adduct of the Active Monoepoxide of Prodrug Treosulfan: First Synthesis, Characterization, and Decomposition Profile Under Physiological Conditions
Romański, Michał, Girreser, Ulrich, Teżyk, Artur, Główka, Franciszek K.
Published in Journal of pharmaceutical sciences (01.11.2018)
Published in Journal of pharmaceutical sciences (01.11.2018)
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Journal Article
Liquid chromatography–tandem mass spectrometry method for simultaneous determination of three N-7-guanine adducts of the active epoxides of prodrug treosulfan in DNA in vitro
Romański, Michał, Rotecki, Konrad, Nowicki, Bartosz, Teżyk, Artur, Główka, Franciszek K.
Published in Talanta (Oxford) (01.06.2019)
Published in Talanta (Oxford) (01.06.2019)
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Journal Article
Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC–ESI–MS/MS method
Romański, Michał, Kasprzyk, Anna, Teżyk, Artur, Widerowska, Agnieszka, Żaba, Czesław, Główka, Franciszek
Published in Journal of pharmaceutical and biomedical analysis (05.06.2017)
Published in Journal of pharmaceutical and biomedical analysis (05.06.2017)
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