Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes
Wu, Yulin, Aquino, Christopher J, Cowan, David J, Anderson, Don L, Ambroso, Jeff L, Bishop, Michael J, Boros, Eric E, Chen, Lihong, Cunningham, Alan, Dobbins, Robert L, Feldman, Paul L, Harston, Lindsey T, Kaldor, Istvan W, Klein, Ryan, Liang, Xi, McIntyre, Maggie S, Merrill, Christine L, Patterson, Kristin M, Prescott, Judith S, Ray, John S, Roller, Shane G, Yao, Xiaozhou, Young, Andrew, Yuen, Josephine, Collins, Jon L
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Journal Article
Mechanisms of idiosyncratic drug reactions: the case of felbamate
Dieckhaus, Christine M, Thompson, Charles D, Roller, Shane G, Macdonald, Timothy L
Published in Chemico-biological interactions (10.11.2002)
Published in Chemico-biological interactions (10.11.2002)
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Journal Article
Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration
Sparks, Steven M., Spearing, Paul K., Diaz, Caroline J., Cowan, David J., Jayawickreme, Channa, Chen, Grace, Rimele, Thomas J., Generaux, Claudia, Harston, Lindsey T., Roller, Shane G.
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
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Journal Article
Interaction between Human Serum Albumin and the Felbamate Metabolites 4-Hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-Phenylpropenal
Roller, Shane G, Dieckhaus, Christine M, Santos, Webster L, Sofia, R. Duane, Macdonald, Timothy L
Published in Chemical research in toxicology (01.06.2002)
Published in Chemical research in toxicology (01.06.2002)
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Journal Article
Discovery of 6,7-Dihydro‑5H‑pyrrolo[2,3‑a]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists
Katamreddy, Subba R, Carpenter, Andrew J, Ammala, Carina E, Boros, Eric E, Brashear, Ron L, Briscoe, Celia P, Bullard, Sarah R, Caldwell, Richard D, Conlee, Christopher R, Croom, Dallas K, Hart, Shane M, Heyer, Dennis O, Johnson, Paul R, Kashatus, Jennifer A, Minick, Doug J, Peckham, Gregory E, Ross, Sean A, Roller, Shane G, Samano, Vicente A, Sauls, Howard R, Tadepalli, Sarva M, Thompson, James B, Xu, Yun, Way, James M
Published in Journal of medicinal chemistry (27.12.2012)
Published in Journal of medicinal chemistry (27.12.2012)
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Journal Article
Role of Glutathione S-Transferases A1-1, M1-1, and P1-1 in the Detoxification of 2-Phenylpropenal, a Reactive Felbamate Metabolite
Dieckhaus, Christine M, Roller, Shane G, Santos, Webster L, Sofia, R. Duane, Macdonald, Timothy L
Published in Chemical research in toxicology (01.05.2001)
Published in Chemical research in toxicology (01.05.2001)
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Journal Article
Abstract 9791: GPR119 Agonism Affects Lipoprotein Particle Remodeling in Dyslipidemic Monkeys
Shadoan, Melanie K, Bergquist, Mandy L, Wagner, Janice D, Roller, Shane G, Nunez, Derek J, Young, Andrew A, Brown, Kathleen K, Prescott, Judith S, Feldman, Paul L
Published in Circulation (New York, N.Y.) (20.11.2012)
Published in Circulation (New York, N.Y.) (20.11.2012)
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Journal Article
Discovery of 6,7-Dihydro-5 H -pyrrolo[2,3- a ]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists
Katamreddy, Subba R., Carpenter, Andrew J., Ammala, Carina E., Boros, Eric E., Brashear, Ron L., Briscoe, Celia P., Bullard, Sarah R., Caldwell, Richard D., Conlee, Christopher R., Croom, Dallas K., Hart, Shane M., Heyer, Dennis O., Johnson, Paul R., Kashatus, Jennifer A., Minick, Doug J., Peckham, Gregory E., Ross, Sean A., Roller, Shane G., Samano, Vicente A., Sauls, Howard R., Tadepalli, Sarva M., Thompson, James B., Xu, Yun, Way, James M.
Published in Journal of medicinal chemistry (27.12.2012)
Published in Journal of medicinal chemistry (27.12.2012)
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Journal Article
EFFICIENT SYNTHESIS OF (±)-seco-CYCLOPROPANEINDOLINE ANALOGS OF CC-1065
Jennings, Sharon A., Toth, James L., Roller, Shane G., Brooks, Natalie, O'Hare, Caroline, Kiakos, Konstantinos, Hartley, John A., Burke, Philip J., Lee, Moses
Published in Heterocyclic communications (2001)
Published in Heterocyclic communications (2001)
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