A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice
Fisher, Timothy S., Hooper, Andrea T., Lucas, Justin, Clark, Tracey H., Rohner, Allison K., Peano, Bryan, Elliott, Mark W., Tsaparikos, Konstantinos, Wang, Hui, Golas, Jonathan, Gavriil, Maria, Haddish-Berhane, Nahor, Tchistiakova, Lioudmila, Gerber, Hans-Peter, Root, Adam R., May, Chad
Published in Cancer Immunology, Immunotherapy (01.02.2018)
Published in Cancer Immunology, Immunotherapy (01.02.2018)
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Journal Article
Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Journal Article
Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
Fisher, Timothy S., Kamperschroer, Cris, Oliphant, Theodore, Love, Victoria A., Lira, Paul D., Doyonnas, Regis, Bergqvist, Simon, Baxi, Sangita M., Rohner, Allison, Shen, Amy C., Huang, Chunli, Sokolowski, Sharon A., Sharp, Leslie L.
Published in Cancer Immunology, Immunotherapy (01.10.2012)
Published in Cancer Immunology, Immunotherapy (01.10.2012)
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Journal Article
Abstract 5111: Bio-distribution and tumor targeting of a P-cadherin x CD3 bi-specific redirected T-cell molecule using fluorescence molecular tomography imaging
Giddabasappa, Anand, Gupta, Vijay, Fisher, Timothy S., David, John, Rand, Norberg, Rohner, Allison, Cohen, Justin, Clark, Tracey, Haddish-Berhane, Nahor, Root, Adam, May, Chad
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier
Rohner, Allison, Spilker, Mary E, Lam, Justine L, Pascual, Bernadette, Bartkowski, Darian, Li, Qing John, Yang, Amy H, Stevens, Greg, Xu, Meirong, Wells, Peter A, Planken, Simon, Nair, Sajiv, Sun, Shaoxian
Published in Molecular cancer therapeutics (01.01.2012)
Published in Molecular cancer therapeutics (01.01.2012)
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Journal Article
Abstract 2476: Bispecific redirected T-cell immunotherapy targeting P-cadherin expressing tumors
Fisher, Timothy S., Root, Adam, Peano, Bryan, Rohner, Allison, Lucas, Justin, Elliott, Mark, Tsaparikos, Konstantinos, Wang, Hui, Golas, Jonathan, Gavriil, Maria, Benard, Susan, He, Tao, Clark, Tracey, Haddish-Berhane, Nahor, Alderson, Ralph, Yang, Yinhua, Johnson, Syd, Moore, Paul, Tchistiakova, Lioudmila, Gerber, Hans-Peter, May, Chad
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 4384: Targeting of 4-1BB by monoclonal antibody, PF-05082566, enhances T cell function and promotes antitumor activity
Fisher, Timothy S., Kamperschroer, Cris, Oliphant, Theodore, Love, Victoria A., Lira, Paul D., Doyonnas, Regis, Bergqvist, Simon, Baxi, Sangita, Rohner, Allison, Shen, Amy C., Huang, Chunli, Sokolowski, Sharon, Sharp, Leslie L.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
4-1BB BINDING MOLECULES
JEROME RICHARD MICHAEL, TESAR MICHAEL, BAXI SANGITA M, DUFIELD ROBERT LEE, DOYONNAS REGIS, ZIEGEMEIER DAISY MARIE, ZULLEY MORITZ, FISHER TIMOTHY SCOTT, ROHNER ALLISON KARLYN, JONES HEATHER LAURENCE, KAMPERSCHROER CRIS, RADHAKRISHNAN VINAY, OLIPHANT THEODORE LAWRENCE, THOMAS KRISTIN ELIZABETH, LADETZKI BAEHS KATHRIN, ONADIPE ADEKUNLE OLATUNBOSUN, BERGQVIST SIMON PAUL, LOVE VICTORIA ALEXANDRIA, AHRENS BIANCA, QIN WENNING, ELLIOTT MARK WILLIAM, YATES LIBBEY ANNE, SHARP LESLIE LYNNE
Year of Publication 15.07.2013
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Year of Publication 15.07.2013
Patent
4-1BB BINDING MOLECULES
JEROME RICHARD MICHAEL, TESAR MICHAEL, BAXI SANGITA M, DUFIELD ROBERT LEE, DOYONNAS REGIS, ZIEGEMEIER DAISY MARIE, ZULLEY MORITZ, FISHER TIMOTHY SCOTT, ROHNER ALLISON KARLYN, JONES HEATHER LAURENCE, KAMPERSCHROER CRIS, RADHAKRISHNAN VINAY, OLIPHANT THEODORE LAWRENCE, THOMAS KRISTIN ELIZABETH, LADETZKI BAEHS KATHRIN, ONADIPE ADEKUNLE OLATUNBOSUN, BERGQVIST SIMON PAUL, LOVE VICTORIA ALEXANDRIA, AHRENS BIANCA, QIN WENNING, ELLIOTT MARK WILLIAM, YATES LIBBEY ANNE, SHARP LESLIE LYNNE
Year of Publication 10.07.2013
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Year of Publication 10.07.2013
Patent
4-1BB BINDING MOLECULES
DUFIELD, ROBERT LEE, ZULLEY, MORITZ, KAMPERSCHROER, CRIS, ROHNER, ALLISON KARLYN, ONADIPE, ADEKUNLE OLATUNBOSUN, BAXI, SANGITA M, BERGQVIST, SIMON PAUL, JONES, HEATHER LAURENCE, LADETZKI-BAEHS, KATHRIN, FISHER, TIMOTHY SCOTT, SHARP, LESLIE LYNNE, THOMAS, KRISTIN ELIZABETH, YATES, LIBBEY ANNE, OLIPHANT, THEODORE LAWRENCE, AHRENS, BIANCA, JEROME, RICHARD MICHAEL, LOVE, VICTORIA ALEXANDRIA, RADHAKRISHNAN, VINAY, DOYONNAS, REGIS, ELLIOTT, MARK WILLIAM, ZIEGEMEIER, DAISY MARIE, TESAR, MICHAEL, QIN, WENNING
Year of Publication 22.06.2021
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Year of Publication 22.06.2021
Patent
4-1BB BINDING MOLECULES
DUFIELD, ROBERT LEE, ZULLEY, MORITZ, KAMPERSCHROER, CRIS, ROHNER, ALLISON KARLYN, ONADIPE, ADEKUNLE OLATUNBOSUN, BAXI, SANGITA M, BERGQVIST, SIMON PAUL, JONES, HEATHER LAURENCE, LADETZKI-BAEHS, KATHRIN, FISHER, TIMOTHY SCOTT, SHARP, LESLIE LYNNE, THOMAS, KRISTIN ELIZABETH, YATES, LIBBEY ANNE, OLIPHANT, THEODORE LAWRENCE, AHRENS, BIANCA, JEROME, RICHARD MICHAEL, LOVE, VICTORIA ALEXANDRIA, RADHAKRISHNAN, VINAY, DOYONNAS, REGIS, ELLIOTT, MARK WILLIAM, ZIEGEMEIER, DAISY MARIE, TESAR, MICHAEL, QIN, WENNING
Year of Publication 03.09.2020
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Year of Publication 03.09.2020
Patent
4-1bb binding molecules
Rohner, Allison Karlyn, Ladetzki-Baehs, Kathrin, Ahrens, Bianca, Sharp, Leslie Lynne, Tesar, Michael, Oliphant, Theodore Lawrence, Fisher, Timothy Scott, Baxi, Sangita M, Love, Victoria Alexandria, Radhakrishnan, Vinay, Ziegemeier, Daisy Marie, Bergqvist, Simon Paul, Doyonnas, Regis, Jerome, Richard Michael, Onadipe, Adekunle Olatunbosun, Zulley, Moritz, Jones, Heather Laurence, Yates, Libbey Anne, Dufield, Robert Lee, Kamperschroer, Cris, Qin, Wenning, Thomas, Kristin Elizabeth, Elliott, Mark William
Year of Publication 31.07.2020
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Year of Publication 31.07.2020
Patent
4-1BB BINDING MOLECULES
DUFIELD, ROBERT LEE, ZULLEY, MORITZ, KAMPERSCHROER, CRIS, ROHNER, ALLISON KARLYN, ONADIPE, ADEKUNLE OLATUNBOSUN, BAXI, SANGITA M, BERGQVIST, SIMON PAUL, JONES, HEATHER LAURENCE, LADETZKI-BAEHS, KATHRIN, FISHER, TIMOTHY SCOTT, SHARP, LESLIE LYNNE, THOMAS, KRISTIN ELIZABETH, YATES, LIBBEY ANNE, OLIPHANT, THEODORE LAWRENCE, AHRENS, BIANCA, JEROME, RICHARD MICHAEL, LOVE, VICTORIA ALEXANDRIA, RADHAKRISHNAN, VINAY, DOYONNAS, REGIS, ELLIOTT, MARK WILLIAM, ZIEGEMEIER, DAISY MARIE, TESAR, MICHAEL, QIN, WENNING
Year of Publication 27.02.2020
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Year of Publication 27.02.2020
Patent
4-1BB BINDING MOLECULES
TESAR, Michael, THOMAS, Kristin Elizabeth, RADHAKRISHNAN, Vinay, DUFIELD, Robert Lee, QIN, Wenning, SHARP, Leslie Lynne, ZIEGEMEIER, Daisy Marie, ZULLEY, Moritz, ROHNER, Allison Karlyn, ELLIOTT, Mark William, KAMPERSCHROER, Cris, LADETZKI-BAEHS, Kathrin, BERGQVIST, Simon Paul, BAXI, Sangita M, JEROME, Richard Michael, FISHER, Timothy Scott, ONADIPE, Adekunle Olatunbosun, AHRENS, Bianca, DOYONNAS, Regis, JONES, Heather Laurence, YATES, Libbey Anne, LOVE, Victoria Alexandria, OLIPHANT, Theodore Lawrence
Year of Publication 28.06.2019
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Year of Publication 28.06.2019
Patent
4-1BB BINDING MOLECULES
DUFIELD, ROBERT LEE, ZULLEY, MORITZ, KAMPERSCHROER, CRIS, ROHNER, ALLISON KARLYN, ONADIPE, ADEKUNLE OLATUNBOSUN, BAXI, SANGITA M, BERGQVIST, SIMON PAUL, JONES, HEATHER LAURENCE, LADETZKI-BAEHS, KATHRIN, FISHER, TIMOTHY SCOTT, SHARP, LESLIE LYNNE, THOMAS, KRISTIN ELIZABETH, YATES, LIBBEY ANNE, OLIPHANT, THEODORE LAWRENCE, AHRENS, BIANCA, JEROME, RICHARD MICHAEL, LOVE, VICTORIA ALEXANDRIA, RADHAKRISHNAN, VINAY, DOYONNAS, REGIS, ELLIOTT, MARK WILLIAM, ZIEGEMEIER, DAISY MARIE, TESAR, MICHAEL, QIN, WENNING
Year of Publication 28.02.2019
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Year of Publication 28.02.2019
Patent
4-1BB BINDING MOLECULES
TESAR, Michael, THOMAS, Kristin Elizabeth, RADHAKRISHNAN, Vinay, DUFIELD, Robert Lee, QIN, Wenning, SHARP, Leslie Lynne, ZIEGEMEIER, Daisy Marie, ZULLEY, Moritz, ROHNER, Allison Karlyn, ELLIOTT, Mark William, KAMPERSCHROER, Cris, LADETZKI-BAEHS, Kathrin, BERGQVIST, Simon Paul, BAXI, Sangita M, JEROME, Richard Michael, FISHER, Timothy Scott, ONADIPE, Adekunle Olatunbosun, AHRENS, Bianca, DOYONNAS, Regis, JONES, Heather Laurence, YATES, Libbey Anne, LOVE, Victoria Alexandria, OLIPHANT, Theodore Lawrence
Year of Publication 13.02.2019
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Year of Publication 13.02.2019
Patent
4-1BB BINDING MOLECULES
BAXI Sangita M, THOMAS Kristin Elizabeth, ELLIOTT Mark William, SHARP Leslie Lynne, DUFIELD Robert Lee, TESAR Michael, LOVE Victoria Alexandria, OLIPHANT Theodore Lawrence, ROHNER Allison Karlyn, FISHER Timothy Scott, RADHAKRISHNAN Vinay, YATES Libbey Anne, ZIEGEMEIER Daisy Marie, AHRENS Bianca, ONADIPE Adekunle Olatunbosun, DOYONNAS Regis, JONES Heather Laurence, BERGQVIST Simon Paul, LADETZKI-BAEHS Kathrin, JEROME Richard Michael, KAMPERSCHROER Cris, QIN Wenning, ZULLEY Moritz
Year of Publication 31.12.2018
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Year of Publication 31.12.2018
Patent
4-1BB-BINDENDE MOLEKYLER
THOMAS, Kristin Elizabeth, TESAR, Michael, RADHAKRISHNAN, Vinay, DUFIELD, Robert Lee, QIN, Wenning, ZULLEY, Moritz, SHARP, Leslie Lynne, ZIEGEMEIER, Daisy Marie, ROHNER, Allison Karlyn, ELLIOTT, Mark William, LADETZKI-BAEHS, Kathrin, KAMPERSCHROER, Cris, BERGQVIST, Simon Paul, BAXI, Sangita M, JEROME, Richard Michael, FISHER, Timothy Scott, ONADIPE, Adekunle Olatunbosun, AHRENS, Bianca, DOYONNAS, Regis, JONES, Heather Laurence, YATES, Libbey Anne, LOVE, Victoria Alexandria, OLIPHANT, Theodore Lawrence
Year of Publication 26.11.2018
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Year of Publication 26.11.2018
Patent
4-1BB BINDING MOLECULES
TESAR, Michael, THOMAS, Kristin Elizabeth, RADHAKRISHNAN, Vinay, DUFIELD, Robert Lee, QIN, Wenning, SHARP, Leslie Lynne, ZIEGEMEIER, Daisy Marie, ZULLEY, Moritz, ROHNER, Allison Karlyn, ELLIOTT, Mark William, KAMPERSCHROER, Cris, LADETZKI-BAEHS, Kathrin, BERGQVIST, Simon Paul, BAXI, Sangita M, JEROME, Richard Michael, FISHER, Timothy Scott, ONADIPE, Adekunle Olatunbosun, AHRENS, Bianca, DOYONNAS, Regis, JONES, Heather Laurence, YATES, Libbey Anne, LOVE, Victoria Alexandria, OLIPHANT, Theodore Lawrence
Year of Publication 03.10.2018
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Year of Publication 03.10.2018
Patent
4-1BB binding molecules
Rohner, Allison Karlyn, Ladetzki-Baehs, Kathrin, Ahrens, Bianca, Sharp, Leslie Lynne, Tesar, Michael, Oliphant, Theodore Lawrence, Fisher, Timothy Scott, Baxi, Sangita M, Love, Victoria Alexandria, Radhakrishnan, Vinay, Ziegemeier, Daisy Marie, Bergqvist, Simon Paul, Doyonnas, Regis, Jerome, Richard Michael, Onadipe, Adekunle Olatunbosun, Zulley, Moritz, Yates, Libbey Anne, Dufield, Robert Lee, Kamperschroer, Cris, Qin, Wenning, Thomas, Kristin Elizabeth, Elliott, Mark William
Year of Publication 05.04.2018
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Year of Publication 05.04.2018
Patent