Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
Get full text
Journal Article
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo
Lorthiois, Edwige, Anderson, Karen, Vulpetti, Anna, Rogel, Olivier, Cumin, Frederic, Ostermann, Nils, Steinbacher, Stefan, Mac Sweeney, Aengus, Delgado, Omar, Liao, Sha-Mei, Randl, Stefan, Rüdisser, Simon, Dussauge, Solene, Fettis, Kamal, Kieffer, Laurence, de Erkenez, Andrea, Yang, Louis, Hartwieg, Constanze, Argikar, Upendra A, La Bonte, Laura R, Newton, Ronald, Kansara, Viral, Flohr, Stefanie, Hommel, Ulrich, Jaffee, Bruce, Maibaum, Jürgen
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
Get full text
Journal Article
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13
Tommasi, Ruben A., Weiler, Sven, McQuire, Leslie W., Rogel, Olivier, Chambers, Mark, Clark, Kirk, Doughty, John, Fang, James, Ganu, Vishwas, Grob, Jonathan, Goldberg, Ronald, Goldstein, Robert, LaVoie, Stacey, Kulathila, Raviraj, Macchia, William, Melton, Richard, Springer, Clayton, Walker, Marc, Zhang, Jing, Zhu, Lijuan, Shultz, Michael
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Get full text
Journal Article
AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF
LORTHIOIS EDWIGE LILIANE JEANNE, POWERS JAMES J, LIU DONGLEI, RANDL STEFAN ANDREAS, JENDZA KEITH, VULPETTI ANNA, BELANGER DAVID B, FLOHR STEFANIE, JI NAN, MAINOLFI NELLO, YOON TAEYOUNG, KARKI RAJESHRI GANESH, ROGEL OLIVIER, GELIN CHRISTINE FANG
Year of Publication 04.04.2016
Get full text
Year of Publication 04.04.2016
Patent
Synthesis of a Potent Antagonist of E-Selectin
Hanessian, Stephen, Mascitti, Vincent, Rogel, Olivier
Published in Journal of organic chemistry (17.05.2002)
Published in Journal of organic chemistry (17.05.2002)
Get full text
Journal Article
Total Synthesis of the Teicoplanin Aglycon
Boger, Dale L, Kim, Seong Heon, Miyazaki, Susumu, Strittmatter, Harald, Weng, Jian-Hui, Mori, Yoshiki, Rogel, Olivier, Castle, Steven L, McAtee, J. Jeffrey
Published in Journal of the American Chemical Society (02.08.2000)
Published in Journal of the American Chemical Society (02.08.2000)
Get full text
Journal Article
SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS
MCQUIRE LESLIE WIGHTON, WEILER SVEN, ROGEL OLIVIER, TOMMASI RUBEN ALBERTO, SHULTZ MICHAEL
Year of Publication 20.04.2011
Get full text
Year of Publication 20.04.2011
Patent
Synthesis of a phostone glycomimetic of the endothelin converting enzyme inhibitor phosphoramidon
Hanessian, Stephen, Rogel, Olivier
Published in Bioorganic & medicinal chemistry letters (16.08.1999)
Published in Bioorganic & medicinal chemistry letters (16.08.1999)
Get full text
Journal Article
ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS
MCQUIRE LESLIE WIGHTON, RIGOLLIER PASCAL, ROGEL OLIVIER, TOMMASI RUBEN ALBERTO, EHRHARDT CLAUS, SHULTZ MICHAEL
Year of Publication 03.12.2010
Get full text
Year of Publication 03.12.2010
Patent
Alternative synthesis and thermal atropisomerism of a fully functionalized DEFG ring system of teicoplanin
Mori, Yoshiki, McAtee, J.Jeffrey, Rogel, Olivier, Boger, Dale L
Published in Tetrahedron letters (27.08.2001)
Published in Tetrahedron letters (27.08.2001)
Get full text
Journal Article
Thermal Atropisomerism of Teicoplanin Aglycon Derivatives: Preparation of the P,P,P and M,P,P Atropisomers of the Teicoplanin Aglycon via Selective Equilibration of the DE Ring System
Boger, Dale L, Weng, Jian-Hui, Miyazaki, Susumu, McAtee, J. Jeffrey, Castle, Steven L, Kim, Seong Heon, Mori, Yoshiki, Rogel, Olivier, Strittmatter, Harald, Jin, Qing
Published in Journal of the American Chemical Society (18.10.2000)
Published in Journal of the American Chemical Society (18.10.2000)
Get full text
Journal Article
ArylSulfonamide-based matrix metalloprotease inhibitors
Shultz Michael David, Rogel Olivier, McQuire Leslie Wighton, Rigollier Pascal, Tommasi Ruben Alberto, Ehrhardt Claus
Year of Publication 21.11.2017
Get full text
Year of Publication 21.11.2017
Patent
COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
MAIBAUM, Juergen Klaus, OSTERMANN, Nils, VULPETTI, Anna, HOMMEL, Ulrich, LORTHIOIS, Edwige Liliane Jeanne, RANDL, Stefan Andreas, ROGEL, Olivier
Year of Publication 20.06.2018
Get full text
Year of Publication 20.06.2018
Patent
ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS
MCQUIRE, LESLIE WIGHTON, SHULTZ, MICHAEL, RIGOLLIER, PASCAL, ROGEL, OLIVIER, EHRHARDT, CLAUS, TOMMASI, RUBEN ALBERTO
Year of Publication 02.05.2017
Get full text
Year of Publication 02.05.2017
Patent
COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
Hommel, Ulrich, Maibaum, Juergen Klaus, Lorthiois, Edwige Liliane, Quancard, Jean, Vulpetti, Anna, Altmann, Eva, Ostermann, Nils, Randl, Stefan Andreas, Rogel, Olivier, Flohr, Stefanie
Year of Publication 21.11.2018
Get full text
Year of Publication 21.11.2018
Patent
COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
Hommel, Ulrich, Maibaum, Juergen Klaus, Lorthois, Edwige Liliane Jeanne, Quancard, Jean, Vulpetti, Anna, Altmann, Eva, Ostermann, Nils, Randl, Stefan Andreas, Rogel, Olivier
Year of Publication 14.11.2018
Get full text
Year of Publication 14.11.2018
Patent