Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance
Small-Saunders, Jennifer L, Hagenah, Laura M, Wicht, Kathryn J, Dhingra, Satish K, Deni, Ioanna, Kim, Jonathan, Vendome, Jeremie, Gil-Iturbe, Eva, Roepe, Paul D, Mehta, Monica, Mancia, Filippo, Quick, Matthias, Eppstein, Margaret J, Fidock, David A
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Published in PLoS pathogens (07.02.2022)
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Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanisms
Suberu, John O, Gorka, Alexander P, Jacobs, Lauren, Roepe, Paul D, Sullivan, Neil, Barker, Guy C, Lapkin, Alexei A
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Published in PloS one (14.11.2013)
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High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations
Mott, Bryan T., Eastman, Richard T., Guha, Rajarshi, Sherlach, Katy S., Siriwardana, Amila, Shinn, Paul, McKnight, Crystal, Michael, Sam, Lacerda-Queiroz, Norinne, Patel, Paresma R., Khine, Pwint, Sun, Hongmao, Kasbekar, Monica, Aghdam, Nima, Fontaine, Shaun D., Liu, Dongbo, Mierzwa, Tim, Mathews-Griner, Lesley A., Ferrer, Marc, Renslo, Adam R., Inglese, James, Yuan, Jing, Roepe, Paul D., Su, Xin-zhuan, Thomas, Craig J.
Published in Scientific reports (25.09.2015)
Published in Scientific reports (25.09.2015)
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An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion
Thornton, L Brock, Teehan, Paige, Floyd, Katherine, Cochrane, Christian, Bergmann, Amy, Riegel, Bryce, Stasic, Andrew J, Di Cristina, Manlio, Moreno, Silvia N J, Roepe, Paul D, Dou, Zhicheng
Published in PLoS pathogens (01.06.2019)
Published in PLoS pathogens (01.06.2019)
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Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology
Hagenah, Laura M, Dhingra, Satish K, Small-Saunders, Jennifer L, Qahash, Tarrick, Willems, Andreas, Schindler, Kyra A, Rangel, Gabriel W, Gil-Iturbe, Eva, Kim, Jonathan, Akhundova, Emiliya, Yeo, Tomas, Okombo, John, Mancia, Filippo, Quick, Matthias, Roepe, Paul D, Llinás, Manuel, Fidock, David A
Published in mBio (16.01.2024)
Published in mBio (16.01.2024)
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Disruption of the Plasmodium falciparum PfPMT Gene Results in a Complete Loss of Phosphatidylcholine Biosynthesis via the Serine-Decarboxylase-Phosphoethanolamine-Methyltransferase Pathway and Severe Growth and Survival Defects
Witola, William Harold, El Bissati, Kamal, Pessi, Gabriella, Xie, Changan, Roepe, Paul D., Mamoun, Choukri Ben
Published in The Journal of biological chemistry (10.10.2008)
Published in The Journal of biological chemistry (10.10.2008)
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Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
Gabryszewski, Stanislaw J, Dhingra, Satish K, Combrinck, Jill M, Lewis, Ian A, Callaghan, Paul S, Hassett, Matthew R, Siriwardana, Amila, Henrich, Philipp P, Lee, Andrew H, Gnädig, Nina F, Musset, Lise, Llinás, Manuel, Egan, Timothy J, Roepe, Paul D, Fidock, David A
Published in PLoS pathogens (10.11.2016)
Published in PLoS pathogens (10.11.2016)
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Novel, Rapid, and Inexpensive Cell-Based Quantification of Antimalarial Drug Efficacy
BENNETT, Tyler N, PAGUIO, Michelle, GLIGORIJEVIC, Bojana, SEUDIEU, Clement, KOSAR, Andrew D, DAVIDSON, Eugene, ROEPE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.05.2004)
Published in Antimicrobial Agents and Chemotherapy (01.05.2004)
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A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum
Gaviria, David, Paguio, Michelle F, Turnbull, Lindsey B, Tan, Asako, Siriwardana, Amila, Ghosh, Debasish, Ferdig, Michael T, Sinai, Anthony P, Roepe, Paul D
Published in PloS one (20.11.2013)
Published in PloS one (20.11.2013)
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Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth
GORKA, Alexander P, ALUMASA, John N, SHERLACH, Katy S, JACOBS, Lauren M, NICKLEY, Katherine B, BROWER, Jonathan P, DE DIOS, Angel C, ROEPE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
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Antiproliferative and Antiplasmodial Dimeric Phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest
Harinantenaina, Liva, Bowman, Jessica D, Brodie, Peggy J, Slebodnick, Carla, Callmander, Martin W, Rakotobe, Etienne, Randrianaivo, Richard, Rasamison, Vincent E, Gorka, Alexander, Roepe, Paul D, Cassera, Maria B, Kingston, David G. I
Published in Journal of natural products (Washington, D.C.) (22.03.2013)
Published in Journal of natural products (Washington, D.C.) (22.03.2013)
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Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross
Patel, Jigar J, Thacker, Drew, Tan, John C, Pleeter, Perri, Checkley, Lisa, Gonzales, Joseph M, Deng, Bingbing, Roepe, Paul D, Cooper, Roland A, Ferdig, Michael T
Published in Molecular microbiology (01.11.2010)
Published in Molecular microbiology (01.11.2010)
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Relative to Quinine and Quinidine, Their 9-Epimers Exhibit Decreased Cytostatic Activity and Altered Heme Binding but Similar Cytocidal Activity versus Plasmodium falciparum
GORKA, Alexander P, SHERLACH, Katy S, DE DIOS, Angel C, ROEPE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
Published in Antimicrobial Agents and Chemotherapy (01.01.2013)
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