Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study
Santoro, Armando, MD, Rimassa, Lorenza, Dr, Borbath, Ivan, MD, Daniele, Bruno, MD, Salvagni, Stefania, MD, Van Laethem, Jean Luc, Prof, Van Vlierberghe, Hans, MD, Trojan, Jörg, Prof, Kolligs, Frank T, Prof, Weiss, Alan, Prof, Miles, Steven, MD, Gasbarrini, Antonio, Prof, Lencioni, Monica, MD, Cicalese, Luca, MD, Sherman, Morris, MD, Gridelli, Cesare, MD, Buggisch, Peter, MD, Gerken, Guido, Prof, Schmid, Roland M, Prof, Boni, Corrado, MD, Personeni, Nicola, MD, Hassoun, Ziad, MD, Abbadessa, Giovanni, MD, Schwartz, Brian, MD, Von Roemeling, Reinhard, MD, Lamar, Maria E, BA, Chen, Yinpu, PhD, Porta, Camillo, MD
Published in The lancet oncology (2013)
Published in The lancet oncology (2013)
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Fimepinostat (CUDC‐907) in patients with relapsed/refractory diffuse large B cell and high‐grade B‐cell lymphoma: report of a phase 2 trial and exploratory biomarker analyses
Landsburg, Daniel J., Barta, Stefan K., Ramchandren, Radhakrishnan, Batlevi, Connie, Iyer, Swaminathan, Kelly, Kevin, Micallef, Ivana N., Smith, Sonali M., Stevens, Don A., Alvarez, Mariano, Califano, Andrea, Shen, Yao, Bosker, Gideon, Parker, Jefferson, Soikes, Raul, Martinez, Elizabeth, Roemeling, Reinhard, Martell, Robert E., Oki, Yasuhiro
Published in British journal of haematology (01.10.2021)
Published in British journal of haematology (01.10.2021)
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Journal Article
VISTA expression and patient selection for immune-based anticancer therapy
Martin, Alexander S, Molloy, Michael, Ugolkov, Andrey, von Roemeling, Reinhard W, Noelle, Randolph J, Lewis, Lionel D, Johnson, Melissa, Radvanyi, Laszlo, Martell, Robert E
Published in Frontiers in immunology (20.02.2023)
Published in Frontiers in immunology (20.02.2023)
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Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993
Burvenich, Ingrid Julienne Georgette, Wichmann, Christian Werner, McDonald, Alexander Franklin, Guo, Nancy, Rigopoulos, Angela, Huynh, Nhi, Vail, Mary, Allen, Stacey, O’Keefe, Graeme Joseph, Scott, Fiona Elizabeth, Soikes, Raul, Angelides, Steven, Roemeling, Reinhard von, Scott, Andrew Mark
Published in European journal of nuclear medicine and molecular imaging (01.11.2024)
Published in European journal of nuclear medicine and molecular imaging (01.11.2024)
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Phase 2, multicenter, open‐label study of tigatuzumab (CS‐1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy‐naive patients with unresectable or metastatic pancreatic cancer
Forero‐Torres, Andres, Infante, Jeffrey R., Waterhouse, David, Wong, Lucas, Vickers, Selwyn, Arrowsmith, Edward, He, Aiwu Ruth, Hart, Lowell, Trent, David, Wade, James, Jin, Xiaoping, Wang, Qiang, Austin, TaShara, Rosen, Michael, Beckman, Robert, Roemeling, Reinhard, Greenberg, Jonathan, Saleh, Mansoor
Published in Cancer medicine (Malden, MA) (01.12.2013)
Published in Cancer medicine (Malden, MA) (01.12.2013)
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Targeting IRAK4 with Emavusertib in Lymphoma Models with Secondary Resistance to PI3K and BTK Inhibitors
Guidetti, Francesca, Arribas, Alberto J, Sartori, Giulio, Spriano, Filippo, Barnabei, Laura, Tarantelli, Chiara, Von Roemeling, Reinhard, Martinez, Elizabeth, Zucca, Emanuele, Bertoni, Francesco
Published in Journal of clinical medicine (04.01.2023)
Published in Journal of clinical medicine (04.01.2023)
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688 Transcriptome analyses in patients with myeloid malignances treated with the IRAK4 inhibitor emavusertib
Metzeler, Klaus H, Platzbecker, Uwe, Winer, Eric S, Verma, Amit, DeAngelo, Daniel J, Severgnini, Mariano, Li, Chia-Cheng, Choudhary, Gaurav S, Zhao, Wanying, Lane, Maureen, Masciarelli, Alyssa, Roemeling, Reinhard Von, Ferrari, Dora, Gallagher, Cole, Carlisle, Samantha, Nickle, David, Garcia-Manero, Guillermo
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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324 Preclinical evaluation of anti-VISTA antibody CI-8993 in a syngeneic huVISTA-KI model
Scott, Fiona, Wichmann, Christian, Burvenich, Ingrid, McDonald, Alexander, Guo, Nancy, Rigopoulos, Angela, Soikes, Raul, Angelides, Steven, Roemeling, Reinhard von, Scott, Andrew
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Tirapazamine Plus Cisplatin Versus Cisplatin in Advanced Non–Small-Cell Lung Cancer: A Report of the International CATAPULT I Study Group
VON PAWEL, J, VON ROEMELING, R, OLVER, I, BERGMAN, B, AYOUB, J, RICHARDSON, G, DUNLOP, D, ARCENAS, A, VESCIO, R, VIALLET, J, TREAT, J, GATZEMEIER, U, BOYER, M, ELISSON, L. O, CLARK, P, TALBOT, D, REY, A, BUTLER, T. W, HIRSH, V
Published in Journal of clinical oncology (13.03.2000)
Published in Journal of clinical oncology (13.03.2000)
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Phase I Trial of Concurrent Tirapazamine, Cisplatin, and Radiotherapy in Patients With Advanced Head and Neck Cancer
RISCHIN, Danny, PETERS, Lester, HICKS, Rodney, HUGHES, Peter, FISHER, Richard, HART, Rosetta, SEXTON, Maree, D'COSTA, Ieta, VON ROEMELING, Reinhard
Published in Journal of clinical oncology (15.01.2001)
Published in Journal of clinical oncology (15.01.2001)
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Trial in Progress: A Phase 1b Single-Arm, Open-Label Study of Emavusertib (CA-4948) in Combination with Azacitidine and Venetoclax in Acute Myeloid Leukemia Patients in Complete Response with Measurable Residual Disease
De La Fuente Burguera, Adolfo, Cerchione, Claudio, Scholl, Sebastian, Middeke, Jan Moritz, Choudhary, Gaurav S, von Roemeling, Reinhard, Platzbecker, Uwe
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Phase III Multinational, Randomized, Double-Blind, Placebo-Controlled Study of Tivantinib (ARQ 197) Plus Erlotinib Versus Erlotinib Alone in Previously Treated Patients With Locally Advanced or Metastatic Nonsquamous Non-Small-Cell Lung Cancer
Scagliotti, Giorgio, von Pawel, Joachim, Novello, Silvia, Ramlau, Rodryg, Favaretto, Adolfo, Barlesi, Fabrice, Akerley, Wallace, Orlov, Sergey, Santoro, Armando, Spigel, David, Hirsh, Vera, Shepherd, Frances A, Sequist, Lecia V, Sandler, Alan, Ross, Jeffrey S, Wang, Qiang, von Roemeling, Reinhard, Shuster, Dale, Schwartz, Brian
Published in Journal of clinical oncology (20.08.2015)
Published in Journal of clinical oncology (20.08.2015)
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Abstract 385: Identification of NF-kappaB phospho-p50 as a predictive biomarker for IRAK4 inhibitor CA-4948 in patients with non-Hodgkin's lymphoma
Ugolkov, Andrey, Samson, Maria, Hok, Rosanna, von Roemeling, Reinhard, Martell, Robert
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Preliminary Safety and Efficacy of Emavusertib (CA-4948) in Acute Myeloid Leukemia Patients with FLT3 Mutation
Winer, Eric S., Verma, Amit, Groepper, Stefanie, Götze, Katharina S. S., Abaza, Yasmin, Schliemann, Christoph, Choudhary, Gaurav S, Zhao, Wanying, Gallagher, Cole, von Roemeling, Reinhard, DeAngelo, Daniel J.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Abstract P073: Pharmacological inhibition of IRAK4 with CA-4948 is beneficial in marginal zone lymphoma models with secondary resistance to PI3K and BTK inhibitors
Guidetti, Francesca, Arribas, Alberto J., Spriano, Filippo, Barnabei, Laura, von Roemeling, Reinhard, Martinez, Elizabeth, Zucca, Emanuele, Bertoni, Francesco
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Preliminary safety, efficacy and molecular characterization of emavusertib (CA-4948) in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) with FLT3 mutation (FLT3m)
Winer, Eric S., Verma, Amit, Groepper, Stefanie, Gotze, Katharina S., Abaza, Yasmin, Mikesch, Jan-Henrik, Choudhary, Gaurav S, Masciarelli, Alyssa, Zhao, Wanying, Gallagher, Cole, Von Roemeling, Reinhard W., DeAngelo, Daniel J.
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
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