LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS -Mutant Lung Adenocarcinoma
Galan-Cobo, Ana, Sitthideatphaiboon, Piyada, Qu, Xiao, Poteete, Alissa, Pisegna, Marlese A, Tong, Pan, Chen, Pei-Hsuan, Boroughs, Lindsey K, Rodriguez, Mirna L M, Zhang, Winter, Parlati, Francesco, Wang, Jing, Gandhi, Varsha, Skoulidis, Ferdinandos, DeBerardinis, Ralph J, Minna, John D, Heymach, John V
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer
Gross, Matt I, Demo, Susan D, Dennison, Jennifer B, Chen, Lijing, Chernov-Rogan, Tania, Goyal, Bindu, Janes, Julie R, Laidig, Guy J, Lewis, Evan R, Li, Jim, Mackinnon, Andrew L, Parlati, Francesco, Rodriguez, Mirna L M, Shwonek, Peter J, Sjogren, Eric B, Stanton, Timothy F, Wang, Taotao, Yang, Jinfu, Zhao, Frances, Bennett, Mark K
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
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Journal Article
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
Steggerda, Susanne M, Bennett, Mark K, Chen, Jason, Emberley, Ethan, Huang, Tony, Janes, Julie R, Li, Weiqun, MacKinnon, Andrew L, Makkouk, Amani, Marguier, Gisele, Murray, Peter J, Neou, Silinda, Pan, Alison, Parlati, Francesco, Rodriguez, Mirna L M, Van de Velde, Lee-Ann, Wang, Tracy, Works, Melissa, Zhang, Jing, Zhang, Winter, Gross, Matthew I
Published in Journal for immunotherapy of cancer (19.12.2017)
Published in Journal for immunotherapy of cancer (19.12.2017)
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Journal Article
Efficacy of pneumococcal nontypable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in young Latin American children: A double-blind randomized controlled trial
Tregnaghi, Miguel W, Sáez-Llorens, Xavier, López, Pio, Abate, Hector, Smith, Enrique, Pósleman, Adriana, Calvo, Arlene, Wong, Digna, Cortes-Barbosa, Carlos, Ceballos, Ana, Tregnaghi, Marcelo, Sierra, Alexandra, Rodriguez, Mirna, Troitiño, Marisol, Carabajal, Carlos, Falaschi, Andrea, Leandro, Ana, Castrejón, Maria Mercedes, Lepetic, Alejandro, Lommel, Patricia, Hausdorff, William P, Borys, Dorota, Ruiz Guiñazú, Javier, Ortega-Barría, Eduardo, Yarzábal, Juan P, Schuerman, Lode
Published in PLoS medicine (01.06.2014)
Published in PLoS medicine (01.06.2014)
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Journal Article
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Magyar, Clara, Braas, Daniel, Graeber, Thomas, Jackson, Nicholas J., Czernin, Johannes, Emberley, Ethan, Gross, Matthew, Janes, Julie, Mackinnon, Andy, Pan, Alison, Rodriguez, Mirna, Works, Melissa, Zhang, Winter, Parlati, Francesco, Demo, Susan, Garon, Edward, Krysan, Kostyantyn, Walser, Tonya C., Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.
Published in Cell reports (Cambridge) (17.01.2017)
Published in Cell reports (Cambridge) (17.01.2017)
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Journal Article
A Novel Brain-Permeant Chemotherapeutic Agent for the Treatment of Brain Metastasis in Triple-Negative Breast Cancer
Deng, Jiaojiao, Chernikova, Sophia B, Wang, Yuelong, Rodriguez, Mirna L, Andersen, Stephanie J, Umeh-Garcia, Maxine C, Godfrey, Bryanna O, Ahmadian, Saman S, Fischer, Wolf-Nicolas, Koller, Kerry J, Jandeleit, Bernd, Ringold, Gordon M, Gephart, Melanie Hayden
Published in Molecular cancer therapeutics (01.11.2021)
Published in Molecular cancer therapeutics (01.11.2021)
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Journal Article
Successful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas
Murga-Zamalloa, Carlos, Webb, Shaun, Reneau, John, Zevallos, Alejandro, Danos-Diaz, Pierina, Perez-Silos, Vanessa, Rodriguez, Mirna, Gao, Guangyao, Fischer, Wolf-Nicolas, Jandeleit, Bernd, Wilcox, Ryan
Published in Leukemia research reports (01.01.2024)
Published in Leukemia research reports (01.01.2024)
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Journal Article
Correction: Efficacy of Pneumococcal Nontypable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV) in Young Latin American Children: A Double-Blind Randomized Controlled Trial
Tregnaghi, Miguel W, Sáez-Llorens, Xavier, López, Pio, Abate, Hector, Smith, Enrique, Pósleman, Adriana, Calvo, Arlene, Wong, Digna, Cortes-Barbosa, Carlos, Ceballos, Ana, Tregnaghi, Marcelo, Sierra, Alexandra, Rodriguez, Mirna, Troitiño, Marisol, Carabajal, Carlos, Falaschi, Andrea, Leandro, Ana, Castrejón, Maria Mercedes, Lepetic, Alejandro, Lommel, Patricia, Hausdorff, William P, Borys, Dorota, Ruiz Guiñazú, Javier, Ortega-Barría, Eduardo, Yarzábal, Juan P, Schuerman, Lode
Published in PLoS medicine (01.06.2015)
Published in PLoS medicine (01.06.2015)
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Journal Article
Wildlife Use of Drainage Structures Under 2 Sections of Federal Highway 2 in the Sky Island Region of Northeastern Sonora, Mexico
Manteca-Rodríguez, Mirna, Félix-Burruel, Ricardo E, Aguilar-Morales, Cecilia, Bravo, Juan Carlos, Traphagen, Myles, Larios, Eugenio
Published in Air, soil and water research (01.01.2021)
Published in Air, soil and water research (01.01.2021)
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Journal Article
Efficacy of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine against acute otitis media and nasopharyngeal carriage in Panamanian children - A randomized controlled trial
Sáez-Llorens, Xavier, Rowley, Stella, Wong, Digna, Rodríguez, Mirna, Calvo, Arlene, Troitiño, Marisol, Salas, Albino, Vega, Vielka, Castrejón, Maria Mercedes, Lommel, Patricia, Pascal, Thierry G., Hausdorff, William P., Borys, Dorota, Ruiz-Guiñazú, Javier, Ortega-Barría, Eduardo, Yarzabal, Juan Pablo, Schuerman, Lode
Published in Human vaccines & immunotherapeutics (03.06.2017)
Published in Human vaccines & immunotherapeutics (03.06.2017)
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Journal Article
Molecular mechanisms of MHC linked susceptibility in leprosy: towards the development of synthetic vaccines
Gorodezky, Clara, Alaez, Carmen, Munguı́a, Andrea, Cruz, Rocı́o, Vazquez, Alejandra, Camacho, Alejandra, Flores, Oscar, Rodriguez, Mirna, Rodriguez, Obdulia
Published in Tuberculosis (Edinburgh, Scotland) (2004)
Published in Tuberculosis (Edinburgh, Scotland) (2004)
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Journal Article
Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A
Botas, Alma, Eitel, Michael, Schwarz, Paul N., Buchmann, Anina, Costales, Paula, Núñez, Luz Elena, Cortés, Jesús, Morís, Francisco, Krawiec, Michał, Wolański, Marcin, Gust, Bertolt, Rodriguez, Mirna, Fischer, Wolf‐Nicolas, Jandeleit, Bernd, Zakrzewska‐Czerwińska, Jolanta, Wohlleben, Wolfgang, Stegmann, Evi, Koch, Pierre, Méndez, Carmen, Gross, Harald
Published in Angewandte Chemie International Edition (07.06.2021)
Published in Angewandte Chemie International Edition (07.06.2021)
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Journal Article
Biomarkers of Response to the Glutaminase Inhibitor CB-839 in Multiple Myeloma Cells
Mackinnon, Andrew, Bennett, Mark, Rodriguez, Mirna, Parlati, Francesco
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
A Novel Blood-Brain Barrier-Permeable Chemotherapeutic Agent for the Treatment of Glioblastoma
Ozawa, Tomoko, Rodriguez, Mirna, Zhao, Guisheng, Yao, Tsun Wen, Fischer, Wolf-Nicolas, Jandeleit, Bernd, Koller, Kerry, Nicolaides, Theodore
Published in Curēus (Palo Alto, CA) (31.08.2021)
Published in Curēus (Palo Alto, CA) (31.08.2021)
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Journal Article
Glutaminase Inhibitor CB-839 Synergizes with Pomalidomide in Preclinical Multiple Myeloma Models
Parlati, Francesco, Gross, Mathew, Janes, Julie, Lewis, Evan, MacKinnon, Andy, Rodriguez, Mirna, Shwonek, Peter, Bennett, Mark
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
Abstract 4711: CB-839, a selective glutaminase inhibitor, synergizes with signal transduction pathway inhibitors to enhance anti-tumor activity
Rodriguez, Mirna, Zhang, Winter, Bennett, Mark, Emberley, Ethan, Gross, Mathew, Janes, Julie, MacKinnon, Andrew, Pan, Alison, Steggerda, Susanne, Works, Melissa, Parlati, Francesco
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 552: Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response
Works, Melissa, Bennett, Mark, Chen, Jason, Emberley, Ethan, Huang, Tony, Janes, Julie, Li, Weiqun, Mackinnon, Andy, Marguier, Gisele, Neou, Silinda, Pan, Alison, Parlati, Francesco, Rodriguez, Mirna, Steggerda, Susanne, Wang, Tracy, Zhang, Jing, Zhang, Winter, Gross, Matthew
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract P1-08-07: A novel pharmacodynamic assay to measure glutaminase inhibition following oral administration of CB-839 in triple negative breast cancer biopsies
MacKinnon, Andy, Bennett, Mark, Emberley, Ethan, Gross, Mathew, Janes, Julie, Lewis, Evan, Pan, Alison, Rodriguez, Mirna, Shwonek, Peter, Wang, Taotao, Yang, Jinfu, Zhao, Frances, Parlati, Francesco
Published in Cancer research (Chicago, Ill.) (01.05.2015)
Published in Cancer research (Chicago, Ill.) (01.05.2015)
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Journal Article
Abstract 4710: Evaluation of the glutaminase inhibitor CB-839 in non-small cell lung cancer
Boroughs, Lindsey K., Chen, Pei-Hsuan, Cai, Ling, Rodriguez, Mirna, Zhang, Winter, Huffman, Kenneth E., Byers, Lauren A., Girard, Luc, Gazdar, Adi F., Heymach, John V., White, Michael A., Minna, John D., Emberley, Ethan, Pan, Alison, Parlati, Frank, DeBerardinis, Ralph J.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract A195: CB-1158 inhibits the immuno-oncology target arginase and causes an immune mediated anti-tumor response
Gross, Matthew, Chen, Jason, Emberley, Ethan, Janes, Julie, Li, Weiqun, Mackinnon, Andy, Pan, Alison, Parlati, Francesco, Rodriguez, Mirna, Steggerda, Susanne, Wang, Tracy, Works, Melissa, Zhang, Jing, Zhang, Winter, Bennett, Mark
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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