IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells
Rodrigues Alves, Ana Paula Nunes, Fernandes, Jaqueline Cristina, Fenerich, Bruna Alves, Coelho-Silva, Juan Luiz, Scheucher, Priscila Santos, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Ridley, Anne J., Machado-Neto, João Agostinho, Traina, Fabiola
Published in Cancer letters (01.08.2019)
Published in Cancer letters (01.08.2019)
Get full text
Journal Article
Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
Machado-Neto, João Agostinho, Fenerich, Bruna Alves, Rodrigues Alves, Ana Paula Nunes, Fernandes, Jaqueline Cristina, Scopim-Ribeiro, Renata, Coelho-Silva, Juan Luiz, Traina, Fabiola
Published in Clinics (São Paulo, Brazil) (01.01.2018)
Published in Clinics (São Paulo, Brazil) (01.01.2018)
Get full text
Journal Article
Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms
Machado-Neto, João Agostinho, Fenerich, Bruna Alves, Scopim-Ribeiro, Renata, Eide, Christopher A., Coelho-Silva, Juan Luiz, Dechandt, Carlos Roberto Porto, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Scheucher, Priscila Santos, Simões, Belinda Pinto, Alberici, Luciane Carla, de Figueiredo Pontes, Lorena Lôbo, Tognon, Cristina E., Druker, Brian J., Rego, Eduardo Magalhães, Traina, Fabiola
Published in Cell death & disease (22.02.2018)
Published in Cell death & disease (22.02.2018)
Get full text
Journal Article
Mantle cell lymphoma harboring Burkitt’s-like translocations presents differential expression of aurora kinase genes compared with others 8q abnormalities
de Oliveira, Fábio Morato, Rodrigues-Alves, Ana Paula Nunes, Lucena-Araújo, Antônio Roberto, de Paula Silva, Ferdinando, da Silva, Fernanda Borges, Falcão, Roberto Passetto
Published in Medical oncology (Northwood, London, England) (01.05.2014)
Published in Medical oncology (Northwood, London, England) (01.05.2014)
Get full text
Journal Article
IRS1/β‐Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells
Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Machado‐Neto, João Agostinho, Scopim‐Ribeiro, Renata, Fenerich, Bruna Alves, da Silva, Fernanda Borges, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Journal of cellular biochemistry (01.07.2017)
Published in Journal of cellular biochemistry (01.07.2017)
Get full text
Journal Article
Reversine triggers mitotic catastrophe and apoptosis in K562 cells
Rodrigues Alves, Ana Paula Nunes, Machado-Neto, João Agostinho, Scheucher, Priscila Santos, Paiva, Helder Henrique, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Leukemia research (01.09.2016)
Published in Leukemia research (01.09.2016)
Get full text
Journal Article
NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells
Fenerich, Bruna Alves, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Scheucher, Priscila Santos, Eide, Christopher A., Tognon, Cristina E., Druker, Brian J., Rego, Eduardo Magalhães, Machado-Neto, João Agostinho, Traina, Fabiola
Published in Signal transduction and targeted therapy (24.01.2020)
Published in Signal transduction and targeted therapy (24.01.2020)
Get full text
Journal Article
Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells
Machado-Neto, João Agostinho, Rodrigues Alves, Ana Paula Nunes, Fernandes, Jaqueline Cristina, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Fenerich, Bruna Alves, da Silva, Fernanda Borges, Scheucher, Priscila Santos, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Heliyon (01.09.2017)
Published in Heliyon (01.09.2017)
Get full text
Journal Article
IRS1/[beta]-Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells
Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Machado-Neto, João Agostinho, Scopim-Ribeiro, Renata, Fenerich, Bruna Alves, da Silva, Fernanda Borges, Simoes, Belinda Pinto, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Journal of cellular biochemistry (01.07.2017)
Published in Journal of cellular biochemistry (01.07.2017)
Get full text
Journal Article
Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1A Expression in Acute Lymphoblastic Leukemia Cells
Rodrigues Alves, Ana Paula Nunes, Machado-Neto, João Agostinho, Fernandes, Jaqueline Cristina, Fenerich, Bruna Alves, da Silva, Fernanda Borges, Scheucher, Priscila Santos, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
Get full text
Journal Article
Multitarget Antileukemic Effects of Metformin in Myeloproliferative Neoplasm Cells: Inhibition of JAK2/STAT Signaling and Mitochondrial Activity
Machado-Neto, João Agostinho, Fenerich, Bruna Alves, Scopim-Ribeiro, Renata, Dechandt, Carlos Roberto Porto, Rodrigues Alves, Ana Paula Nunes, Fernandes, Jaqueline Cristina, Scheucher, Priscila Santos, Simões, Belinda Pinto, Alberici, Luciane Carla, Pontes, Lorena Lôbo de Figueiredo, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
Get full text
Journal Article
The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms
Fenerich, Bruna Alves, Machado-Neto, João Agostinho, Alves, Ana Paula Nunes Rodrigues, Campos, Paula De Melo, Fernandes, Jaqueline Cristina, Coelho-Silva, Juan Luiz, Ribeiro, Renata Scopim, da Silva, Fernanda B, Scheucher, Priscila Santos, Figueiredo-Pontes, Lorena Lobo, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
Get full text
Journal Article
Metformin Reduces Tumor Burden and Splenomegaly in JAK2V617F Murine Models
Machado-Neto, João Agostinho, Ribeiro, Renata Scopim, Coelho-Silva, Juan Luiz, Eide, Christopher A., Fenerich, Bruna Alves, Fernandes, Jaqueline Cristina, Alves, Ana Paula Nunes Rodrigues, Scheucher, Priscila S, Tognon, Cristina E., Figueiredo-Pontes, Lorena Lobo, Druker, Brian J., Rego, Eduardo Magalhães, Traina, Fabiola
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
Get full text
Journal Article
NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2 V617F -positive myeloproliferative neoplasm cells
Fenerich, Bruna Alves, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Scheucher, Priscila Santos, Eide, Christopher A, Tognon, Cristina E, Druker, Brian J, Rego, Eduardo Magalhães, Machado-Neto, João Agostinho, Traina, Fabiola
Published in Signal transduction and targeted therapy (24.01.2020)
Get full text
Published in Signal transduction and targeted therapy (24.01.2020)
Journal Article
NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2 V617F -positive myeloproliferative neoplasm cells
Fenerich, Bruna Alves, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Scheucher, Priscila Santos, Eide, Christopher A, Tognon, Cristina E, Druker, Brian J, Rego, Eduardo Magalhães, Machado-Neto, João Agostinho, Traina, Fabiola
Published in Signal transduction and targeted therapy (2020)
Get full text
Published in Signal transduction and targeted therapy (2020)
Journal Article
Metformin exerts multitarget antileukemia activity in JAK2 V617F -positive myeloproliferative neoplasms
Machado-Neto, João Agostinho, Fenerich, Bruna Alves, Scopim-Ribeiro, Renata, Eide, Christopher A, Coelho-Silva, Juan Luiz, Dechandt, Carlos Roberto Porto, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Scheucher, Priscila Santos, Simões, Belinda Pinto, Alberici, Luciane Carla, de Figueiredo Pontes, Lorena Lôbo, Tognon, Cristina E, Druker, Brian J, Rego, Eduardo Magalhães, Traina, Fabiola
Published in Cell death & disease (22.02.2018)
Get full text
Published in Cell death & disease (22.02.2018)
Journal Article