Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)
Mercer, Swati P., Roecker, Anthony J., Garson, Susan, Reiss, Duane R., Meacham Harrell, C., Murphy, Kathy L., Bruno, Joseph G., Bednar, Rodney A., Lemaire, Wei, Cui, Donghui, Cabalu, Tamara D., Tang, Cuyue, Prueksaritanont, Thomayant, Hartman, George D., Young, Steven D., Winrow, Christopher J., Renger, John J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an N,N‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats
Whitman, David B., Cox, Christopher D., Breslin, Michael J., Brashear, Karen M., Schreier, John D., Bogusky, Michael J., Bednar, Rodney A., Lemaire, Wei, Bruno, Joseph G., Hartman, George D., Reiss , Duane R., Harrell, C. Meacham, Kraus, Richard L., Li, Yuxing, Garson, Susan L., Doran, Scott M., Prueksaritanont, Thomayant, Li, Chunze, Winrow, Christopher J., Koblan, Kenneth S., Renger, John J., Coleman, Paul J.
Published in ChemMedChem (06.07.2009)
Published in ChemMedChem (06.07.2009)
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Journal Article
Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist
Garner, Rachel, Gopalakrishnan, Shobha, McCauley, John A., Bednar, Rodney A., Gaul, Stanley L., Mosser, Scott D., Kiss, Laszlo, Lynch, Joseph J., Patel, Shil, Fandozzi, Christine, Lagrutta, Armando, Briscoe, Richard, Liverton, Nigel J., Paterson, Blake M., Vornov, James J., Mazhari, Reza
Published in Pharmacology research & perspectives (01.12.2015)
Published in Pharmacology research & perspectives (01.12.2015)
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Journal Article
Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists
Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.
Published in ACS chemical neuroscience (20.07.2011)
Published in ACS chemical neuroscience (20.07.2011)
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Journal Article
Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists
Nguyen, Kevin T., Claiborne, Christopher F., McCauley, John A., Libby, Brian E., Claremon, David A., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Connolly, Thomas M., Condra, Cindra L., Bednar, Bohumil, Stump, Gary L., Lynch, Joseph J., Koblan, Kenneth S., Liverton, Nigel J.
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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Journal Article
Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties
Coleman, Paul J., Schreier, John D., Cox, Christopher D., Breslin, Michael J., Whitman, David B., Bogusky, Michael J., McGaughey, Georgia B., Bednar, Rodney A., Lemaire, Wei, Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Harrell, C. Meacham, Reiss, Duane R., Cabalu, Tamara D., Cui, Donghui, Prueksaritanont, Thomayant, Stevens, Joanne, Tannenbaum, Pamela L., Ball, Richard G., Stellabott, Joyce, Young, Steven D., Hartman, George D., Winrow, Christopher J., Renger, John J.
Published in ChemMedChem (05.03.2012)
Published in ChemMedChem (05.03.2012)
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Journal Article
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
Uebele, Victor N, Nuss, Cindy E, Fox, Steven V, Garson, Susan L, Cristescu, Razvan, Doran, Scott M, Kraus, Richard L, Santarelli, Vincent P, Li, Yuxing, Barrow, James C, Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Rittle, Kenneth E, Reger, Thomas S, Bednar, Rodney A, Lemaire, Wei, Mullen, Faith A, Ballard, Jeanine E, Tang, Cuyue, Dai, Ge, McManus, Owen B, Koblan, Kenneth S, Renger, John J
Published in Cell biochemistry and biophysics (01.11.2009)
Published in Cell biochemistry and biophysics (01.11.2009)
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Journal Article
The discovery of highly potent CGRP receptor antagonists
Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Bruno, Joseph G., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Salvatore, Christopher A., Theberge, Cory R., Blair Zartman, C., Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist
Liverton, Nigel J, Bednar, Rodney A, Bednar, Bohumil, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Cunningham, Michael, DiLella, Anthony G, Gaul, Stanley L, Libby, Brian E, Lyle, Elizabeth A, Lynch, Joseph J, McCauley, John A, Mosser, Scott D, Nguyen, Kevin T, Stump, Gary L, Sun, Hong, Wang, Hao, Yergey, James, Koblan, Kenneth S
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Journal Article
Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality
Wood, Michael R., Schirripa, Kathy M., Kim, June J., Bednar, Rodney A., Fay, John F., Bruno, Joseph G., Moore, Eric L., Mosser, Scott D., Roller, Shane, Salvatore, Christopher A., Vacca, Joseph P., Selnick, Harold G.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists
Bell, Ian M., Bednar, Rodney A., Fay, John F., Gallicchio, Steven N., Hochman, Jerome H., McMasters, Daniel R., Miller-Stein, Cynthia, Moore, Eric L., Mosser, Scott D., Pudvah, Nicole T., Quigley, Amy G., Salvatore, Christopher A., Stump, Craig A., Theberge, Cory R., Wong, Bradley K., Zartman, C. Blair, Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Journal Article
Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility
Wood, Michael R., Schirripa, Kathy M., Kim, June J., Quigley, Amy G., Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Fay, John F., Bruno, Joseph G., Moore, Eric L., Mosser, Scott D., Roller, Shane, Salvatore, Christopher A., Kane, Stefanie A., Vacca, Joseph P., Selnick, Harold G.
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Journal Article
Potent benzimidazolone-based CGRP receptor antagonists
THEBERGE, Cory R, BEDNAR, Rodney A, WILLIAMS, Theresa M, ZARTMAN, C. Blair, ZHANG, Xu-Fang, GRAHAM, Samuel L, VACCA, Joseph P, BELL, Ian M, CORCORAN, Halea A, FAY, John F, HERSHEY, James C, JOHNSTON, Victor K, KANE, Stefanie A, MOSSER, Scott, SALVATORE, Christopher A
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists
McIntyre, Charles J., McCauley, John A., Bednar, Bohumil, Bednar, Rodney A., Butcher, John W., Claremon, David A., Cunningham, Michael E., Freidinger, Roger M., Gaul, Stanley L., Homnick, Carl F., Koblan, Ken S., Mosser, Scott D., Romano, Joseph J., Liverton, Nigel J.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
Identification of potent, highly constrained CGRP receptor antagonists
Stump, Craig A., Bell, Ian M., Bednar, Rodney A., Fay, John F., Gallicchio, Steven N., Hershey, James C., Jelley, Richard, Kreatsoulas, Constantine, Moore, Eric L., Mosser, Scott D., Quigley, Amy G., Roller, Shane A., Salvatore, Christopher A., Sharik, Steven S., Theberge, Cory R., Zartman, C. Blair, Kane, Stefanie A., Graham, Samuel L., Selnick, Harold G., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Journal Article
NR2B-Selective N-Methyl-d-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles
McCauley, John A., Theberge, Cory R., Romano, Joseph J., Billings, Susan B., Anderson, Kenneth D., Claremon, David A., Freidinger, Roger M., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Connolly, Thomas M., Condra, Cindra L., Xia, Menghang, Cunningham, Michael E., Bednar, Bohumil, Stump, Gary L., Lynch, Joseph J., Macaulay, Alison, Wafford, Keith A., Koblan, Kenneth S., Liverton, Nigel J.
Published in Journal of medicinal chemistry (08.04.2004)
Published in Journal of medicinal chemistry (08.04.2004)
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Journal Article
Proline bis-amides as potent dual orexin receptor antagonists
Bergman, Jeffrey M., Roecker, Anthony J., Mercer, Swati P., Bednar, Rodney A., Reiss, Duane R., Ransom, Richard W., Meacham Harrell, C., Pettibone, Douglas J., Lemaire, Wei, Murphy, Kathy L., Li, Chunze, Prueksaritanont, Thomayant, Winrow, Christopher J., Renger, John J., Koblan, Kenneth S., Hartman, George D., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry (15.02.2008)
Published in Bioorganic & medicinal chemistry (15.02.2008)
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Journal Article
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists
Bell, Ian M., Bednar, Rodney A., Corcoran, Halea A., Fay, John F., Gallicchio, Steven N., Johnston, Victor K., Hershey, James C., Miller-Stein, Cynthia M., Moore, Eric L., Mosser, Scott D., Roller, Shane A., Salvatore, Christopher A., Theberge, Cory R., Wong, Bradley K., Blair Zartman, C., Kane, Stefanie A., Williams, Theresa M., Graham, Samuel L., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Cover Picture: Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012)
Coleman, Paul J., Schreier, John D., Cox, Christopher D., Breslin, Michael J., Whitman, David B., Bogusky, Michael J., McGaughey, Georgia B., Bednar, Rodney A., Lemaire, Wei, Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Harrell, C. Meacham, Reiss, Duane R., Cabalu, Tamara D., Cui, Donghui, Prueksaritanont, Thomayant, Stevens, Joanne, Tannenbaum, Pamela L., Ball, Richard G., Stellabott, Joyce, Young, Steven D., Hartman, George D., Winrow, Christopher J., Renger, John J.
Published in ChemMedChem (05.03.2012)
Published in ChemMedChem (05.03.2012)
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