Potent N-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel
Bilodeau, Mark T, Balitza, Adrienne E, Koester, Timothy J, Manley, Peter J, Rodman, Leonard D, Buser-Doepner, Carolyn, Coll, Kathleen E, Fernandes, Christine, Gibbs, Jackson B, Heimbrook, David C, Huckle, William R, Kohl, Nancy, Lynch, Joseph J, Mao, Xianzhi, McFall, Rosemary C, McLoughlin, Debra, Miller-Stein, Cynthia M, Rickert, Keith W, Sepp-Lorenzino, Laura, Shipman, Jennifer M, Subramanian, Raju, Thomas, Kenneth A, Wong, Bradley K, Yu, Sean, Hartman, George D
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Journal Article
The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase
Bilodeau, Mark T., Rodman, Leonard D., McGaughey, Georgia B., Coll, Kathleen E., Koester, Timothy J., Hoffman, William F., Hungate, Randall W., Kendall, Richard L., McFall, Rosemary C., Rickert, Keith W., Rutledge, Ruth Z., Thomas, Kenneth A.
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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Journal Article
2,4-Disubstituted pyrimidines: A novel class of KDR kinase inhibitors
Manley, Peter J., Balitza, Adrienne E., Bilodeau, Mark T., Coll, Kathleen E., Hartman, George D., McFall, Rosemary C., Rickert, Keith W., Rodman, Leonard D., Thomas, Kenneth A.
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
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Journal Article
2,4-Disubstituted Pyrimidines: A Novel Class of KDR Kinase Inhibitors
Manley, Peter J., Balitza, Adrienne E., Bilodeau, Mark T., Coll, Kathleen E., Hartman, George D., McFall, Rosemary C., Rickert, Keith W., Rodman, Leonard D., Thomas, Kenneth A.
Published in ChemInform (16.09.2003)
Published in ChemInform (16.09.2003)
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