SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
Hamblett, Kevin J, Jacob, Allison P, Gurgel, Jesse L, Tometsko, Mark E, Rock, Brooke M, Patel, Sonal K, Milburn, Robert R, Siu, Sophia, Ragan, Seamus P, Rock, Dan A, Borths, Christopher J, O'Neill, Jason W, Chang, Wesley S, Weidner, Margaret F, Bio, Matthew M, Quon, Kim C, Fanslow, William C
Published in Cancer research (Chicago, Ill.) (15.12.2015)
Published in Cancer research (Chicago, Ill.) (15.12.2015)
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Journal Article
Characterization of ritonavir-mediated inactivation of cytochrome P450 3A4
Rock, Brooke M, Hengel, Shawna M, Rock, Dan A, Wienkers, Larry C, Kunze, Kent L
Published in Molecular pharmacology (01.12.2014)
Published in Molecular pharmacology (01.12.2014)
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Journal Article
POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices
Thayer, Mai B, Humphreys, Sara C, Chung, Kyu S, Lade, Julie M, Cook, Kevin D, Rock, Brooke M
Published in Scientific reports (26.06.2020)
Published in Scientific reports (26.06.2020)
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Journal Article
Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC
Basiri, Babak, Xie, Fang, Wu, Bin, Humphreys, Sara C., Lade, Julie M., Thayer, Mai B., Yamaguchi, Pam, Florio, Monica, Rock, Brooke M.
Published in Molecular therapy. Nucleic acids (04.09.2020)
Published in Molecular therapy. Nucleic acids (04.09.2020)
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Journal Article
Characterization of the active site properties of CYP4F12
Eksterowicz, John, Rock, Dan A, Rock, Brooke M, Wienkers, Larry C, Foti, Robert S
Published in Drug metabolism and disposition (01.10.2014)
Published in Drug metabolism and disposition (01.10.2014)
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Journal Article
Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)
Koren, Michael J, Moriarty, Patrick Maurice, Baum, Seth J, Neutel, Joel, Hernandez-Illas, Martha, Weintraub, Howard S, Florio, Monica, Kassahun, Helina, Melquist, Stacey, Varrieur, Tracy, Haldar, Saptarsi M, Sohn, Winnie, Wang, Huei, Elliott-Davey, Mary, Rock, Brooke M, Pei, Tao, Homann, Oliver, Hellawell, Jennifer, Watts, Gerald F
Published in Nature medicine (01.01.2022)
Published in Nature medicine (01.01.2022)
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Journal Article
Universal Automated Immunoaffinity Purification-CE−MS Platform for Accelerating Next Generation Biologic Design
Han, Mei, Wang, Yunan, Cook, Kevin, Bala, Noor, Soto, Marcus, Rock, Dan A, Pearson, Josh T, Rock, Brooke M
Published in Analytical chemistry (Washington) (06.04.2021)
Published in Analytical chemistry (Washington) (06.04.2021)
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Journal Article
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs
Bai, Nan, Riching, Kristin M., Makaju, Aman, Wu, Hao, Acker, Timothy M., Ou, Shu-Ching, Zhang, Yaru, Shen, Xiaomeng, Bulloch, Daryl N., Rui, Huan, Gibson, Bradford W., Daniels, Danette L., Urh, Marjeta, Rock, Brooke M., Humphreys, Sara C.
Published in The Journal of biological chemistry (01.04.2022)
Published in The Journal of biological chemistry (01.04.2022)
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Journal Article
Absorption, Distribution, Metabolism, and Excretion of [ 14 C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
Dahal, Upendra P, Rock, Brooke M, Rodgers, John, Shen, Xiaomeng, Wang, Zhe, Wahlstrom, Jan L
Published in Drug metabolism and disposition (01.05.2022)
Published in Drug metabolism and disposition (01.05.2022)
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Journal Article
Deciphering the Exact Sequence of Endogenous Soluble B Cell Maturation Antigen and Unbiased Quantitation in Multiple Myeloma Patient Samples by LC-MS
Shen, Xiaomeng, Dong, Xue, Shi, Jianxia, Chen, Hao, Lan, Yun, Lim, Ai Ching, Xie, Fang, Ang, Agnes, Kratzer, Andrea, Rock, Dan A, Rock, Brooke M
Published in Clinical chemistry (Baltimore, Md.) (04.01.2024)
Published in Clinical chemistry (Baltimore, Md.) (04.01.2024)
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Journal Article
Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development
Humphreys, Sara C, Thayer, Mai B, Campbell, Jabbar, Chen, Wen Li Kelly, Adams, Dan, Lade, Julie M, Rock, Brooke M
Published in Journal of medicinal chemistry (25.06.2020)
Published in Journal of medicinal chemistry (25.06.2020)
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Journal Article
Immunoaffinity capture coupled with capillary electrophoresis - mass spectrometry to study therapeutic protein stability in vivo
Han, Mei, Pearson, Josh T., Wang, Yunan, Winters, Dwight, Soto, Marcus, Rock, Dan A., Rock, Brooke M.
Published in Analytical biochemistry (15.12.2017)
Published in Analytical biochemistry (15.12.2017)
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Journal Article
Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics
Thayer, Mai B, Lade, Julie M, Doherty, David, Xie, Fang, Basiri, Babak, Barnaby, Omar S, Bala, Noor S, Rock, Brooke M
Published in Scientific reports (05.03.2019)
Published in Scientific reports (05.03.2019)
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Journal Article
Plasma and Liver Protein Binding of N -Acetylgalactosamine-Conjugated Small Interfering RNA
Humphreys, Sara C, Thayer, Mai B, Lade, Julie M, Wu, Bin, Sham, Kelvin, Basiri, Babak, Hao, Yue, Huang, Xin, Smith, Richard, Rock, Brooke M
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Journal Article
Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles
Barr, John T, Wang, Zhican, Min, Xiaoshan, Wienkers, Henry J, Rock, Brooke M, Rock, Dan A, Wienkers, Larry C
Published in Drug metabolism and disposition (01.06.2020)
Published in Drug metabolism and disposition (01.06.2020)
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Journal Article
Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution
Conner, Kip P, Rock, Brooke M, Kwon, Gayle K, Balthasar, Joseph P, Abuqayyas, Lubna, Wienkers, Larry C, Rock, Dan A
Published in Drug metabolism and disposition (01.11.2014)
Published in Drug metabolism and disposition (01.11.2014)
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Journal Article
Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
Rock, Brooke M, Tometsko, Mark E, Patel, Sonal K, Hamblett, Kevin J, Fanslow, William C, Rock, Dan A
Published in Drug metabolism and disposition (01.09.2015)
Published in Drug metabolism and disposition (01.09.2015)
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Journal Article