Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis
Robles‐Valero, Javier, Fernández‐Nevado, Lucía, Lorenzo‐Martín, L Francisco, Cuadrado, Myriam, Fernández‐Pisonero, Isabel, Rodríguez‐Fdez, Sonia, Astorga‐Simón, Elsa N, Abad, Antonio, Caloto, Rubén, Bustelo, Xosé R
Published in The EMBO journal (15.11.2021)
Published in The EMBO journal (15.11.2021)
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Journal Article
Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model
Robles‐Valero, Javier, Fernández‐Nevado, Lucía, Cuadrado, Myriam, Lorenzo‐Martín, Luis Francisco, Fernández‐Pisonero, Isabel, Abad, Antonio, Redín, Esther, Montuenga, Luis, Martín‐Zanca, Dionisio, Bigas, Anna, Mallo, Moisés, Dosil, Mercedes, Bustelo, Xosé R.
Published in Molecular oncology (01.10.2022)
Published in Molecular oncology (01.10.2022)
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Journal Article
Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge
Ramírez‐Santiago, Guillermo, Robles‐Valero, Javier, Morlino, Giulia, Cruz‐Adalia, Aranzazu, Pérez‐Martínez, Manuel, Zaldivar, Airen, Torres‐Torresano, Mónica, Chichón, Francisco Javier, Sorrentino, Andrea, Pereiro, Eva, Carrascosa, José L., Megías, Diego, Sorzano, Carlos Oscar S., Sánchez‐Madrid, Francisco, Veiga, Esteban
Published in European journal of immunology (01.10.2016)
Published in European journal of immunology (01.10.2016)
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Journal Article
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas
Abate, Francesco, da Silva-Almeida, Ana C., Zairis, Sakellarios, Robles-Valero, Javier, Couronne, Lucile, Khiabanian, Hossein, Quinn, S. Aidan, Kim, Mi-Yeon, Laginestra, Maria Antonella, Kim, Christine, Fiore, Danilo, Bhagat, Govind, Piris, Miguel Angel, Campo, Elias, Lossos, Izidore S., Bernard, Olivier A., Inghirami, Giorgio, Pileri, Stefano, Bustelo, Xosé R., Rabadan, Raul, Ferrando, Adolfo A., Palomero, Teresa
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2017)
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Journal Article
Miro-1 Links Mitochondria and Microtubule Dynein Motors To Control Lymphocyte Migration and Polarity
Morlino, Giulia, Barreiro, Olga, Baixauli, Francesc, Robles-Valero, Javier, González-Granado, José M., Villa-Bellosta, Ricardo, Cuenca, Jesús, Sánchez-Sorzano, Carlos O., Veiga, Esteban, Martín-Cófreces, Noa B., Sánchez-Madrid, Francisco
Published in Molecular and cellular biology (01.04.2014)
Published in Molecular and cellular biology (01.04.2014)
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Journal Article
Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis
Conde, Javier, Fernández-Pisonero, Isabel, Cuadrado, Myriam, Abad, Antonio, Robles-Valero, Javier, Bustelo, Xosé R.
Published in Biomedicines (19.06.2021)
Published in Biomedicines (19.06.2021)
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Journal Article
Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
González, Nazareno, Cardama, Georgina A, Chinestrad, Patricio, Robles-Valero, Javier, Rodríguez-Fdez, Sonia, Lorenzo-Martín, L Francisco, Bustelo, Xosé R, Lorenzano Menna, Pablo, Gomez, Daniel E
Published in Frontiers in cell and developmental biology (15.04.2020)
Published in Frontiers in cell and developmental biology (15.04.2020)
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Journal Article
An unexpected tumor suppressor role for VAV1a
Bustelo, Xosé R., Lorenzo-Martín, L. Francisco, Cuadrado, Myriam, Fernández-Pisonero, Isabel, Robles-Valero, Javier
Published in Molecular & cellular oncology (04.05.2018)
Published in Molecular & cellular oncology (04.05.2018)
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Journal Article
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
Robles-Valero, Javier, Lorenzo-Martín, L. Francisco, Menacho-Márquez, Mauricio, Fernández-Pisonero, Isabel, Abad, Antonio, Camós, Mireia, Toribio, María L., Espinosa, Lluis, Bigas, Anna, Bustelo, Xosé R.
Published in Cancer cell (13.11.2017)
Published in Cancer cell (13.11.2017)
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Journal Article
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Lorenzo-Martín, L. Francisco, Fernández-Parejo, Natalia, Menacho-Márquez, Mauricio, Rodríguez-Fdez, Sonia, Robles-Valero, Javier, Zumalave, Sonia, Fabbiano, Salvatore, Pascual, Gloria, García-Pedrero, Juana M., Abad, Antonio, García-Macías, María C., González, Nazareno, Lorenzano-Menna, Pablo, Pavón, Miguel A., González-Sarmiento, Rogelio, Segrelles, Carmen, Paramio, Jesús M., Tubío, José M. C., Rodrigo, Juan P., Benitah, Salvador A., Cuadrado, Myriam, Bustelo, Xosé R.
Published in Nature communications (22.09.2020)
Published in Nature communications (22.09.2020)
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Journal Article
Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor
Lorenzo-Martín, L. Francisco, Rodríguez-Fdez, Sonia, Fabbiano, Salvatore, Abad, Antonio, García-Macías, María C., Dosil, Mercedes, Cuadrado, Myriam, Robles-Valero, Javier, Bustelo, Xosé R.
Published in Oncogene (09.07.2020)
Published in Oncogene (09.07.2020)
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Journal Article
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
Fernández-Pisonero, Isabel, Clavaín, Laura, Robles-Valero, Javier, Lorenzo-Martín, L. Francisco, Caloto, Rubén, Nieto, Blanca, García-Macías, Carmen, Oeste, Clara L., Sánchez-Martín, Manuel, Abad, Antonio, Hortal, Alejandro, Caballero, Dolores, González, Marcos, Dosil, Mercedes, Alarcón, Balbino, Bustelo, Xosé R.
Published in Cell reports (Cambridge) (15.03.2022)
Published in Cell reports (Cambridge) (15.03.2022)
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Journal Article
MTOC translocation modulates IS formation and controls sustained T cell signaling
Martín-Cófreces, Noa B, Robles-Valero, Javier, Cabrero, J. Román, Mittelbrunn, María, Gordón-Alonso, Mónica, Sung, Ching-Hwa, Alarcón, Balbino, Vázquez, Jesús, Sánchez-Madrid, Francisco
Published in The Journal of cell biology (08.09.2008)
Published in The Journal of cell biology (08.09.2008)
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Journal Article
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms
Lorenzo-Martín, L. Francisco, Citterio, Carmen, Menacho-Márquez, Mauricio, Conde, Javier, Larive, Romain M., Rodríguez-Fdez, Sonia, García-Escudero, Ramón, Robles-Valero, Javier, Cuadrado, Myriam, Fernández-Pisonero, Isabel, Dosil, Mercedes, Sevilla, María A., Montero, María J., Fernández-Salguero, Pedro M., Paramio, Jesús M., Bustelo, Xosé R.
Published in Oncogene (01.01.2019)
Published in Oncogene (01.01.2019)
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Journal Article
Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions
Fabbiano, Salvatore, Menacho-Márquez, Mauricio, Robles-Valero, Javier, Pericacho, Miguel, Matesanz-Marín, Adela, García-Macías, Carmen, Sevilla, María A., Montero, M. J., Alarcón, Balbino, López-Novoa, José M., Martín, Pilar, Bustelo, Xosé R.
Published in Molecular and cellular biology (01.10.2015)
Published in Molecular and cellular biology (01.10.2015)
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Journal Article
Endosomal clathrin drives actin accumulation at the immunological synapse
Calabia-Linares, Carmen, Robles-Valero, Javier, de la Fuente, Hortensia, Perez-Martinez, Manuel, Martín-Cofreces, Noa, Alfonso-Pérez, Manuel, Gutierrez-Vázquez, Cristina, Mittelbrunn, María, Ibiza, Sales, Urbano-Olmos, Francisco R, Aguado-Ballano, Covadonga, Sánchez-Sorzano, Carlos Oscar, Sanchez-Madrid, Francisco, Veiga, Esteban
Published in Journal of cell science (01.03.2011)
Published in Journal of cell science (01.03.2011)
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Journal Article