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Published in PLoS computational biology (13.12.2021)
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The allosteric modulation of complement C5 by knob domain peptides
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Published in eLife (11.02.2021)
Published in eLife (11.02.2021)
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Journal Article
The allosteric modulation of Complement C5 by knob domain peptides
Macpherson, Alex, Laabei, Maisem, Ahdash, Zainab, Graewert, Melissa, Birtley, James R, Schulze, Sarah, Crennell, Susan, Robinson, Sarah A, Holmes, Ben, Oleinikovas, Vladas, Nilsson, Per H, Snowden, James, Ellis, Victoria, Mollnes, Tom Eirik, Deane, Charlotte M, Svergun, Dmitri, Lawson, Alastair Dg, Van Den Elsen, Jean
Published in bioRxiv (25.10.2020)
Published in bioRxiv (25.10.2020)
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Paper
Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
CHAKRAVARTY, PAROMA, MCCLORY, ANDREW, XU, JIE, IDING, HANS, ZHANG, HAIMING, LIM, NGAIP-KIE, ROBINSON, SARAH, CHUNG, CHEOL KEUN, CLAGG, KYLE, GOSSELIN, FRANCIS, NAGAPUDI, KARTHIK, DALZIEL, MICHAEL, FETTES, ALEC
Year of Publication 01.07.2024
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Year of Publication 01.07.2024
Patent
SOLID FORMS OF 3-((1R,3R)-1-(2,6-DIFLUORO-4-((1-(3-FLUOROPROPYL)AZETIDIN-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOL-2-YL)-2,2-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY, INCLUDING METHODS OF THEIR USE
XU JIE, CLAGG KYLE, NAGAPUDI KARTHIK, DALZIEL MICHAEL, CHUNG CHEOL-KEUN, GOSSELIN FRANCIS, CHAKRAVARTY PAROMA, IDING HANS, FETTES ALEC, ZHANG HAIMING, ROBINSON SARAH, MCCLORY ANDREW, LIM NGIAP-KIE
Year of Publication 02.03.2021
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Year of Publication 02.03.2021
Patent
Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-B]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted
CHAKRAVARTY, PAROMA, MCCLORY, ANDREW, XU, JIE, IDING, HANS, ZHANG, HAIMING, LIM, NGAIP-KIE, ROBINSON, SARAH, CHUNG, CHEOL KEUN, CLAGG, KYLE, GOSSELIN, FRANCIS, NAGAPUDI, KARTHIK, DALZIEL, MICHAEL, FETTES, ALEC
Year of Publication 01.05.2020
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Year of Publication 01.05.2020
Patent
3-1R3R-1-26--4-1-3--3--3--1349--2H-[34-b]-2--22--1- SOLID FORMS OF 3-1R3R-1-26-DIFLUORO-4-1-3-FLUOROPROPYLAZETIDIN-3-YLAMINOPHENYL-3-METHYL-1349-TETRAHYDRO-2H-PYRIDO[34-B]INDOL-2-YL-22-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY INCLUDING METHODS OF THEIR USE
XU JIE, CLAGG KYLE, NAGAPUDI KARTHIK, DALZIEL MICHAEL, GOSSELIN FRANCIS, CHAKRAVARTY PAROMA, CHUNG CHEOL KEUN, IDING HANS, FETTES ALEC, ZHANG HAIMING, ROBINSON SARAH, MCCLORY ANDREW, LIM NGIAP-KIE
Year of Publication 22.07.2024
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Year of Publication 22.07.2024
Patent
3-1R3R-1-26--4-1-3--3--3--1349--2H-[34-b]-2--22--1- SOLID FORMS OF 3-1R3R-1-26-DIFLUORO-4-1-3-FLUOROPROPYLAZETIDIN-3-YLAMINOPHENYL-3-METHYL-1349-TETRAHYDRO-2H-PYRIDO[34-B]INDOL-2-YL-22-DIFLUOROPROPAN-1-OL AND PROCESSES FOR PREPARING FUSED TRICYCLIC COMPOUNDS COMPRISING A SUBSTITUTED PHENYL OR PYRIDINYL MOIETY INCLUDING METHODS OF THEIR USE
XU JIE, CLAGG KYLE, NAGAPUDI KARTHIK, DALZIEL MICHAEL, GOSSELIN FRANCIS, CHAKRAVARTY PAROMA, CHUNG CHEOL KEUN, IDING HANS, FETTES ALEC, ZHANG HAIMING, ROBINSON SARAH, MCCLORY ANDREW, LIM NGIAP KIE
Year of Publication 09.08.2023
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Year of Publication 09.08.2023
Patent
3-((1R,3R)-1--3-메틸-1,3,4,9-테트라하이드로-2H-피리도[3,4-b]인돌-2-일)-2,2-다이플루오로프로판-1-올의 고체 형태, 치환된 페닐 또는 피리딘일 잔기를 포함하는 융합된 삼환형 화합물의 제조 방법, 및 이의 사용 방법
XU JIE, CLAGG KYLE, NAGAPUDI KARTHIK, DALZIEL MICHAEL, GOSSELIN FRANCIS, CHAKRAVARTY PAROMA, CHUNG CHEOL KEUN, IDING HANS, FETTES ALEC, ZHANG HAIMING, ROBINSON SARAH, MCCLORY ANDREW, LIM NGIAP KIE
Year of Publication 03.03.2021
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Year of Publication 03.03.2021
Patent