Improving oral absorption of a rapidly crystallizing parent drug using prodrug strategy: Comparison of phosphate versus glycine based prodrugs
Indulkar, Anura S., Slade, Russell, Jana, Navendu, Frey, Robin R., Penning, Thomas D., Lai, Albert, Leblanc, Alix F.
Published in Journal of pharmaceutical sciences (03.10.2024)
Published in Journal of pharmaceutical sciences (03.10.2024)
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Journal Article
Discovery of Potent Azetidine-Benzoxazole MerTK Inhibitors with In Vivo Target Engagement
Frey, Robin R., Jana, Navendu, Gorman, Jacob V., Wang, Jin, Smith, Heath A., Bromberg, Kenneth D., Thakur, Ashish, Doktor, Stella Z., Indulkar, Anura S., Jakob, Clarissa G., Upadhyay, Anup K., Qiu, Wei, Manaves, Vlasios, Gambino, Frank, Valentino, Stephen A., Montgomery, Debra, Zhou, Yebin, Li, Tao, Buchanan, Fritz G., Ferguson, Debra C., Kurnick, Matthew D., Kapecki, Nicolas, Lai, Albert, Michaelides, Michael R., Penning, Thomas D.
Published in Journal of medicinal chemistry (10.10.2024)
Published in Journal of medicinal chemistry (10.10.2024)
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Journal Article
Discovery of A‑910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor
Yu, Yiyun, Jang, Miyeon, Miyashiro, Julie, Clark, Richard F., Zhu, Gui-Dong, Gong, Jane, Dai, Yujia, Frey, Robin R., Penning, Thomas D., Kim, Hadong, Lee, Hyung Ki, Kim, Jin Kwan, Ryu, Ki Moon, Park, Seong Jin, Yoon, Taeyoung, Li, Tao, Kurnick, Matthew D., Kapecki, Nicolas J., Li, Leiming, Gorman, Jacob V., Montgomery, Debra A., Manaves, Vlasios, Bromberg, Kenneth D., Doktor, Stella Z., Thakur, Ashish, Wang, Jin, Smith, Heath A., Buchanan, Fritz G., Ferguson, Debra C., Torrent, Maricel, Jakob, Clarissa G., Qiu, Wei, Upadhyay, Anup K., Martin, Ruth L., Lai, Albert, Michaelides, Michael R.
Published in Journal of medicinal chemistry (10.10.2024)
Published in Journal of medicinal chemistry (10.10.2024)
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Journal Article
Heterocyclic ketones as inhibitors of histone deacetylase
Vasudevan, Anil, Ji, Zhiqin, Frey, Robin R., Wada, Carol K., Steinman, Douglas, Heyman, H.Robin, Guo, Yan, Curtin, Michael L., Guo, Jun, Li, Junling, Pease, Lori, Glaser, Keith B., Marcotte, Patrick A., Bouska, Jennifer J., Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Journal Article
Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors
Dai, Yujia, Guo, Yan, Frey, Robin R, Ji, Zhiqin, Curtin, Michael L, Ahmed, Asma A, Albert, Daniel H, Arnold, Lee, Arries, Shannon S, Barlozzari, Teresa, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Pease, Lori J, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Wishart, Neil, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Journal Article
Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor
Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors
Frey, Robin R, Curtin, Michael L, Albert, Daniel H, Glaser, Keith B, Pease, Lori J, Soni, Niru B, Bouska, Jennifer J, Reuter, David, Stewart, Kent D, Marcotte, Patrick, Bukofzer, Gail, Li, Junling, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Journal Article
Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families
Glaser, Keith B, Li, Junling, Marcotte, Patrick A, Magoc, Terrance J, Guo, Jun, Reuter, David R, Tapang, Paul, Wei, Ru-Qi, Pease, Lori J, Bui, Mai H, Chen, Zehan, Frey, Robin R, Johnson, Eric F, Osterling, Donald J, Olson, Amanda M, Bouska, Jennifer J, Luo, Yanping, Curtin, Michael L, Donawho, Cherrie K, Michaelides, Michael R, Tse, Chris, Davidsen, Steven K, Albert, Daniel H
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
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Journal Article
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families
Curtin, Michael L., Frey, Robin R., Heyman, H. Robin, Soni, Niru B., Marcotte, Patrick A., Pease, Lori J., Glaser, Keith B., Magoc, Terrance J., Tapang, Paul, Albert, Daniel H., Osterling, Donald J., Olson, Amanda M., Bouska, Jennifer J., Guan, Zhiwen, Preusser, Lee C., Polakowski, James S., Stewart, Kent D., Tse, Chris, Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Journal Article
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases
Curtin, Michael L., Robin Heyman, H., Frey, Robin R., Marcotte, Patrick A., Glaser, Keith B., Jankowski, James R., Magoc, Terrance J., Albert, Daniel H., Olson, Amanda M., Reuter, David R., Bouska, Jennifer J., Montgomery, Debra A., Palma, Joann P., Donawho, Cherrie K., Stewart, Kent D., Tse, Chris, Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Journal Article
Trifluoromethyl ketones as inhibitors of histone deacetylase
Frey, Robin R., Wada, Carol K., Garland, Robert B., Curtin, Michael L., Michaelides, Michael R., Li, Junling, Pease, Lori J., Glaser, Keith B., Marcotte, Patrick A., Bouska, Jennifer J., Murphy, Shannon S., Davidsen, Steven K.
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Journal Article
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC)
CURTIN, Michael L, GARLAND, Robert B, HEYMAN, H. Robin, FREY, Robin R, MICHAELIDES, Michael R, JUNLING LI, PEASE, Lori J, GLASER, Keith B, MARCOTTE, Patrick A, DAVIDSEN, Steven K
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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Journal Article
Thienopyridine urea inhibitors of KDR kinase
Heyman, H. Robin, Frey, Robin R., Bousquet, Peter F., Cunha, George A., Moskey, Maria D., Ahmed, Asma A., Soni, Niru B., Marcotte, Patrick A., Pease, Lori J., Glaser, Keith B., Yates, Melinda, Bouska, Jennifer J., Albert, Daniel H., Black-Schaefer, Candace L., Dandliker, Peter J., Stewart, Kent D., Rafferty, Paul, Davidsen, Steven K., Michaelides, Michael R., Curtin, Michael L.
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
α-Keto amides as inhibitors of histone deacetylase
Wada, Carol K., Frey, Robin R., Ji, Zhiqin, Curtin, Michael L., Garland, Robert B., Holms, James H., Li, Junling, Pease, Lori J., Guo, Jun, Glaser, Keith B., Marcotte, Patrick A., Richardson, Paul L., Murphy, Shannon S., Bouska, Jennifer J., Tapang, Paul, Magoc, Terrance J., Albert, Daniel H., Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
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Journal Article
4-Amino-5-aryl-6-arylethynylpyrimidines: Structure–activity relationships of non-nucleoside adenosine kinase inhibitors
Matulenko, Mark A., Paight, Ernest S., Frey, Robin R., Gomtsyan, Arthur, DiDomenico, Stanley, Jiang, Meiqun, Lee, Chih-Hung, Stewart, Andrew O., Yu, Haixia, Kohlhaas, Kathy L., Alexander, Karen M., McGaraughty, Steve, Mikusa, Joseph, Marsh, Kennan C., Muchmore, Steven W., Jakob, Clarissa L., Kowaluk, Elizabeth A., Jarvis, Michael F., Bhagwat, Shripad S.
Published in Bioorganic & medicinal chemistry (15.02.2007)
Published in Bioorganic & medicinal chemistry (15.02.2007)
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Journal Article
Design, Synthesis, and Evaluation of Matrix Metalloprotease Inhibitors Bearing Cyclopropane-Derived Peptidomimetics as P1‘ and P2‘ Replacements
Reichelt, Andreas, Gaul, Christoph, Frey, Robin R, Kennedy, April, Martin, Stephen F
Published in Journal of organic chemistry (14.06.2002)
Published in Journal of organic chemistry (14.06.2002)
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Journal Article
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors
Matulenko, Mark A., Lee, Chih-Hung, Jiang, Meiqun, Frey, Robin R., Cowart, Marlon D., Bayburt, Erol K., DiDomenico, Stanley, Gfesser, Gregory A., Gomtsyan, Arthur, Zheng, Guo Zhu, McKie, Jeffery A., Stewart, Andrew O., Yu, Haixia, Kohlhaas, Kathy L., Alexander, Karen M., McGaraughty, Steve, Wismer, Carol T., Mikusa, Joseph, Marsh, Kennan C., Snyder, Ronald D., Diehl, Marilyn S., Kowaluk, Elizabeth A., Jarvis, Michael F., Bhagwat, Shripad S.
Published in Bioorganic & medicinal chemistry (01.06.2005)
Published in Bioorganic & medicinal chemistry (01.06.2005)
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Journal Article
Expression and functional characterization of recombinant human HDAC1 and HDAC3
Li, Junling, Staver, Michael J, Curtin, Michael L, Holms, James H, Frey, Robin R, Edalji, Rohinton, Smith, Richard, Michaelides, Mike R, Davidsen, Steven K, Glaser, Keith B
Published in Life sciences (1973) (16.04.2004)
Published in Life sciences (1973) (16.04.2004)
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Journal Article
Isoindolinone ureas: a novel class of KDR kinase inhibitors
Curtin, Michael L, Frey, Robin R, Heyman, H.Robin, Sarris, Kathy A, Steinman, Douglas H, Holmes, James H, Bousquet, Peter F, Cunha, George A, Moskey, Maria D, Ahmed, Asma A, Pease, Lori J, Glaser, Keith B, Stewart, Kent D, Davidsen, Steven K, Michaelides, Michael R
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
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