An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K, Seong, Bo Kyung A, Dharia, Neekesh V, Kuljanin, Miljan, Wechsler, Caroline S, Kugener, Guillaume, Robichaud, Amanda L, Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A, Mancias, Joseph D, Younger, Scott T, Piccioni, Federica, Lee, Lynn H, Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly
Published in Cancer discovery (01.02.2022)
Published in Cancer discovery (01.02.2022)
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EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Durbin, Adam D, Wang, Tingjian, Wimalasena, Virangika K, Zimmerman, Mark W, Li, Deyao, Dharia, Neekesh V, Mariani, Luca, Shendy, Noha A M, Nance, Stephanie, Patel, Anand G, Shao, Ying, Mundada, Maya, Maxham, Lily, Park, Paul M C, Sigua, Logan H, Morita, Ken, Conway, Amy Saur, Robichaud, Amanda L, Perez-Atayde, Antonio R, Bikowitz, Melissa J, Quinn, Taylor R, Wiest, Olaf, Easton, John, Schönbrunn, Ernst, Bulyk, Martha L, Abraham, Brian J, Stegmaier, Kimberly, Look, A Thomas, Qi, Jun
Published in Cancer discovery (01.03.2022)
Published in Cancer discovery (01.03.2022)
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Journal Article
Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy
Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Dimitrov, Boris, Kitara, Samuel, Diehl, Frances F, Robichaud, Amanda L, Conway, Amy Saur, Ross, Linda, Su, Angela, Ling, Frank, Qi, Jun, Roti, Giovanni, Lewis, Caroline A, Puissant, Alexandre, Vander Heiden, Matthew G, Stegmaier, Kimberly
Published in Leukemia (01.02.2022)
Published in Leukemia (01.02.2022)
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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
Iniguez, Amanda Balboni, Alexe, Gabriela, Wang, Emily Jue, Roti, Giovanni, Patel, Sarvagna, Chen, Liying, Kitara, Samuel, Conway, Amy, Robichaud, Amanda L., Stolte, Björn, Bandopadhayay, Pratiti, Goodale, Amy, Pantel, Sasha, Lee, Yenarae, Cheff, Dorian M., Hall, Matthew D., Guha, Rajarshi, Davis, Mindy I., Menard, Marie, Nasholm, Nicole, Weiss, William A., Qi, Jun, Beroukhim, Rameen, Piccioni, Federica, Johannessen, Cory, Stegmaier, Kimberly
Published in Cancer cell (10.12.2018)
Published in Cancer cell (10.12.2018)
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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham S., Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly
Published in Cancer cell (14.06.2021)
Published in Cancer cell (14.06.2021)
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Journal Article
A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma
Guenther, Lillian M, Dharia, Neekesh V, Ross, Linda, Conway, Amy, Robichaud, Amanda L, Catlett, 2nd, Jerrel L, Wechsler, Caroline S, Frank, Elizabeth S, Goodale, Amy, Church, Alanna J, Tseng, Yuen-Yi, Guha, Rajarshi, McKnight, Crystal G, Janeway, Katherine A, Boehm, Jesse S, Mora, Jaume, Davis, Mindy I, Alexe, Gabriela, Piccioni, Federica, Stegmaier, Kimberly
Published in Clinical cancer research (15.02.2019)
Published in Clinical cancer research (15.02.2019)
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Journal Article
Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma
Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Morgan, Ann M, Alexe, Gabriela, Schauer, Nathan J, Liu, Xiaoxi, Bird, Gregory H, Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J, Walensky, Loren D, Stegmaier, Kimberly
Published in The Journal of experimental medicine (06.08.2018)
Published in The Journal of experimental medicine (06.08.2018)
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Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Ellegast, Jana M, Alexe, Gabriela, Hamze, Amanda, Lin, Shan, Uckelmann, Hannah J, Rauch, Philipp J, Pimkin, Maxim, Ross, Linda S, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Khalid, Delan, Perry, Jennifer A, Wunderlich, Mark, Benajiba, Lina, Pikman, Yana, Nabet, Behnam, Gray, Nathanael S, Orkin, Stuart H, Stegmaier, Kimberly
Published in Cancer discovery (06.07.2022)
Published in Cancer discovery (06.07.2022)
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Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer
Malone, Clare F, Dharia, Neekesh V, Kugener, Guillaume, Forman, Alexandra B, Rothberg, Michael V, Abdusamad, Mai, Gonzalez, Alfredo, Kuljanin, Miljan, Robichaud, Amanda L, Conway, Amy Saur, Dempster, Joshua M, Paolella, Brenton R, Dumont, Nancy, Hovestadt, Volker, Mancias, Joseph D, Younger, Scott T, Root, David E, Golub, Todd R, Vazquez, Francisca, Stegmaier, Kimberly
Published in Cancer discovery (01.09.2021)
Published in Cancer discovery (01.09.2021)
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Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Paolino, Jonathan, Dimitrov, Boris, Apsel Winger, Beth, Sandoval-Perez, Angelica, Rangarajan, Amith Vikram, Ocasio-Martinez, Nicole, Tsai, Harrison K, Li, Yuting, Robichaud, Amanda L, Khalid, Delan, Hatton, Charlie, Gillani, Riaz, Polonen, Petri, Dilig, Anthony, Gotti, Giacomo, Kavanagh, Julia, Adhav, Asmani A, Gow, Sean, Tsai, Jonathan, Li, Yen Der, Ebert, Benjamin L, Van Allen, Eliezer M, Bledsoe, Jacob, Kim, Annette S, Tasian, Sarah K, Cooper, Stacy L, Cooper, Todd M, Hijiya, Nobuko, Sulis, Maria Luisa, Shukla, Neerav N, Magee, Jeffrey A, Mullighan, Charles G, Burke, Michael J, Luskin, Marlise R, Mar, Brenton G, Jacobson, Matthew P, Harris, Marian H, Stegmaier, Kimberly, Place, Andrew E, Pikman, Yana
Published in Clinical cancer research (14.11.2023)
Published in Clinical cancer research (14.11.2023)
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Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
Pikman, Yana, Tasian, Sarah K, Sulis, Maria Luisa, Stevenson, Kristen, Blonquist, Traci M, Apsel Winger, Beth, Cooper, Todd M, Pauly, Melinda, Maloney, Kelly W, Burke, Michael J, Brown, Patrick A, Gossai, Nathan, McNeer, Jennifer L, Shukla, Neerav N, Cole, Peter D, Kahn, Justine M, Chen, Jing, Barth, Matthew J, Magee, Jeffrey A, Gennarini, Lisa, Adhav, Asmani A, Clinton, Catherine M, Ocasio-Martinez, Nicole, Gotti, Giacomo, Li, Yuting, Lin, Shan, Imamovic, Alma, Tognon, Cristina E, Patel, Tasleema, Faust, Haley L, Contreras, Cristina F, Cremer, Anjali, Cortopassi, Wilian A, Garrido Ruiz, Diego, Jacobson, Matthew P, Dharia, Neekesh V, Su, Angela, Robichaud, Amanda L, Saur Conway, Amy, Tarlock, Katherine, Stieglitz, Elliot, Place, Andrew E, Puissant, Alexandre, Hunger, Stephen P, Kim, Annette S, Lindeman, Neal I, Gore, Lia, Janeway, Katherine A, Silverman, Lewis B, Tyner, Jeffrey W, Harris, Marian H, Loh, Mignon L, Stegmaier, Kimberly
Published in Cancer discovery (01.06.2021)
Published in Cancer discovery (01.06.2021)
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Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Mabe, Nathaniel W, Huang, Min, Dalton, Guillermo N, Alexe, Gabriela, Schaefer, Daniel A, Geraghty, Anna C, Robichaud, Amanda L, Conway, Amy S, Khalid, Delan, Mader, Marius M, Belk, Julia A, Ross, Kenneth N, Sheffer, Michal, Linde, Miles H, Ly, Nghi, Yao, Winnie, Rotiroti, Maria Caterina, Smith, Benjamin A H, Wernig, Marius, Bertozzi, Carolyn R, Monje, Michelle, Mitsiades, Constantine S, Majeti, Ravindra, Satpathy, Ansuman T, Stegmaier, Kimberly, Majzner, Robbie G
Published in Nature cancer (01.08.2022)
Published in Nature cancer (01.08.2022)
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Journal Article
Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma
Pikman, Yana, Conway, Amy Saur, Robichaud, Amanda L., Kitara, Samuel, Church, Alanna J., Kennedy, Alyssa L., Silverman, Lewis B., Billett, Amy L., Weinstock, David M., Harris, Marian H., Stegmaier, Kimberly
Published in Blood advances (14.04.2020)
Published in Blood advances (14.04.2020)
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Journal Article
Abstract 2318: EP300 selectively controls the enhancer landscape of high risk neuroblastoma
Durbin, Adam D., Wang, Tingjian, Wimalasena, Virangika K., Zimmerman, Mark W., Li, Deyao, Dharia, Neekesh V., Mariani, Luca, Park, Paul M., Sigua, Logan H., Morita, Ken, Conway, Amy S., Robichaud, Amanda L., Perez-Atayde, Antonio, Bikowitz, Melissa, Quinn, Taylor, Wiest, Olaf, Schonbrunn, Ernst, Bulyk, Martha, Abraham, Brian J., Stegmaier, Kimberly, Look, A. Thomas, Qi, Jun
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 1629: Targeting resistance mechanisms to CDK4/6 inhibitors in Ewing sarcoma with an IGF1R inhibitor drug combination strategy
Guenther, Lillian M., Dharia, Neekesh V., Ross, Linda, Conway, Amy S., Robichaud, Amanda L., Church, Alanna J., Guha, Rajarshi, Davis, Mindy I., Alexe, Gabriela, Mora, Jaume, Piccioni, Federica, Stegmaier, Kimberly
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts
Ellegast, Jana M., Alexe, Gabriela, Hamze, Amanda, Lin, Shan, Uckelmann, Hannah J., Rauch, Philipp J., Pimkin, Maxim, Ross, Linda, Dharia, Neekesh V., Robichaud, Amanda L., Saur, Amy Conway, Khalid, Delan, Wunderlich, Mark, Benajiba, Lina, Nabet, Behnam, Gray, Nathanael S., Orkin, Stuart H., Stegmaier, Kimberly
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy
Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Kitara, Samuel, Diehl, Frances F, Robichaud, Amanda L, Conway, Amy, Su, Angela, Qi, Jun, Roti, Giovanni, Lewis, Caroline A, Puissant, Alexandre, Vander Heiden, Matthew G, Stegmaier, Kimberly
Published in bioRxiv (07.02.2020)
Published in bioRxiv (07.02.2020)
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