Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
Nabet, Behnam, Ferguson, Fleur M., Seong, Bo Kyung A., Kuljanin, Miljan, Leggett, Alan L., Mohardt, Mikaela L., Robichaud, Amanda, Conway, Amy S., Buckley, Dennis L., Mancias, Joseph D., Bradner, James E., Stegmaier, Kimberly, Gray, Nathanael S.
Published in Nature communications (18.09.2020)
Published in Nature communications (18.09.2020)
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An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K, Seong, Bo Kyung A, Dharia, Neekesh V, Kuljanin, Miljan, Wechsler, Caroline S, Kugener, Guillaume, Robichaud, Amanda L, Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A, Mancias, Joseph D, Younger, Scott T, Piccioni, Federica, Lee, Lynn H, Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly
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Published in Cancer discovery (01.02.2022)
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EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Durbin, Adam D, Wang, Tingjian, Wimalasena, Virangika K, Zimmerman, Mark W, Li, Deyao, Dharia, Neekesh V, Mariani, Luca, Shendy, Noha A M, Nance, Stephanie, Patel, Anand G, Shao, Ying, Mundada, Maya, Maxham, Lily, Park, Paul M C, Sigua, Logan H, Morita, Ken, Conway, Amy Saur, Robichaud, Amanda L, Perez-Atayde, Antonio R, Bikowitz, Melissa J, Quinn, Taylor R, Wiest, Olaf, Easton, John, Schönbrunn, Ernst, Bulyk, Martha L, Abraham, Brian J, Stegmaier, Kimberly, Look, A Thomas, Qi, Jun
Published in Cancer discovery (01.03.2022)
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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
Iniguez, Amanda Balboni, Alexe, Gabriela, Wang, Emily Jue, Roti, Giovanni, Patel, Sarvagna, Chen, Liying, Kitara, Samuel, Conway, Amy, Robichaud, Amanda L., Stolte, Björn, Bandopadhayay, Pratiti, Goodale, Amy, Pantel, Sasha, Lee, Yenarae, Cheff, Dorian M., Hall, Matthew D., Guha, Rajarshi, Davis, Mindy I., Menard, Marie, Nasholm, Nicole, Weiss, William A., Qi, Jun, Beroukhim, Rameen, Piccioni, Federica, Johannessen, Cory, Stegmaier, Kimberly
Published in Cancer cell (10.12.2018)
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Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy
Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Dimitrov, Boris, Kitara, Samuel, Diehl, Frances F., Robichaud, Amanda L., Conway, Amy Saur, Ross, Linda, Su, Angela, Ling, Frank, Qi, Jun, Roti, Giovanni, Lewis, Caroline A., Puissant, Alexandre, Vander Heiden, Matthew G., Stegmaier, Kimberly
Published in Leukemia (01.02.2022)
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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma
Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham S., Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly
Published in Cancer cell (14.06.2021)
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A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma
Guenther, Lillian M, Dharia, Neekesh V, Ross, Linda, Conway, Amy, Robichaud, Amanda L, Catlett, 2nd, Jerrel L, Wechsler, Caroline S, Frank, Elizabeth S, Goodale, Amy, Church, Alanna J, Tseng, Yuen-Yi, Guha, Rajarshi, McKnight, Crystal G, Janeway, Katherine A, Boehm, Jesse S, Mora, Jaume, Davis, Mindy I, Alexe, Gabriela, Piccioni, Federica, Stegmaier, Kimberly
Published in Clinical cancer research (15.02.2019)
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Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma
Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Morgan, Ann M, Alexe, Gabriela, Schauer, Nathan J, Liu, Xiaoxi, Bird, Gregory H, Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J, Walensky, Loren D, Stegmaier, Kimberly
Published in The Journal of experimental medicine (06.08.2018)
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Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Ellegast, Jana M, Alexe, Gabriela, Hamze, Amanda, Lin, Shan, Uckelmann, Hannah J, Rauch, Philipp J, Pimkin, Maxim, Ross, Linda S, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Khalid, Delan, Perry, Jennifer A, Wunderlich, Mark, Benajiba, Lina, Pikman, Yana, Nabet, Behnam, Gray, Nathanael S, Orkin, Stuart H, Stegmaier, Kimberly
Published in Cancer discovery (06.07.2022)
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Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer
Malone, Clare F, Dharia, Neekesh V, Kugener, Guillaume, Forman, Alexandra B, Rothberg, Michael V, Abdusamad, Mai, Gonzalez, Alfredo, Kuljanin, Miljan, Robichaud, Amanda L, Conway, Amy Saur, Dempster, Joshua M, Paolella, Brenton R, Dumont, Nancy, Hovestadt, Volker, Mancias, Joseph D, Younger, Scott T, Root, David E, Golub, Todd R, Vazquez, Francisca, Stegmaier, Kimberly
Published in Cancer discovery (01.09.2021)
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Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Paolino, Jonathan, Dimitrov, Boris, Apsel Winger, Beth, Sandoval-Perez, Angelica, Rangarajan, Amith Vikram, Ocasio-Martinez, Nicole, Tsai, Harrison K, Li, Yuting, Robichaud, Amanda L, Khalid, Delan, Hatton, Charlie, Gillani, Riaz, Polonen, Petri, Dilig, Anthony, Gotti, Giacomo, Kavanagh, Julia, Adhav, Asmani A, Gow, Sean, Tsai, Jonathan, Li, Yen Der, Ebert, Benjamin L, Van Allen, Eliezer M, Bledsoe, Jacob, Kim, Annette S, Tasian, Sarah K, Cooper, Stacy L, Cooper, Todd M, Hijiya, Nobuko, Sulis, Maria Luisa, Shukla, Neerav N, Magee, Jeffrey A, Mullighan, Charles G, Burke, Michael J, Luskin, Marlise R, Mar, Brenton G, Jacobson, Matthew P, Harris, Marian H, Stegmaier, Kimberly, Place, Andrew E, Pikman, Yana
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Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
Pikman, Yana, Tasian, Sarah K, Sulis, Maria Luisa, Stevenson, Kristen, Blonquist, Traci M, Apsel Winger, Beth, Cooper, Todd M, Pauly, Melinda, Maloney, Kelly W, Burke, Michael J, Brown, Patrick A, Gossai, Nathan, McNeer, Jennifer L, Shukla, Neerav N, Cole, Peter D, Kahn, Justine M, Chen, Jing, Barth, Matthew J, Magee, Jeffrey A, Gennarini, Lisa, Adhav, Asmani A, Clinton, Catherine M, Ocasio-Martinez, Nicole, Gotti, Giacomo, Li, Yuting, Lin, Shan, Imamovic, Alma, Tognon, Cristina E, Patel, Tasleema, Faust, Haley L, Contreras, Cristina F, Cremer, Anjali, Cortopassi, Wilian A, Garrido Ruiz, Diego, Jacobson, Matthew P, Dharia, Neekesh V, Su, Angela, Robichaud, Amanda L, Saur Conway, Amy, Tarlock, Katherine, Stieglitz, Elliot, Place, Andrew E, Puissant, Alexandre, Hunger, Stephen P, Kim, Annette S, Lindeman, Neal I, Gore, Lia, Janeway, Katherine A, Silverman, Lewis B, Tyner, Jeffrey W, Harris, Marian H, Loh, Mignon L, Stegmaier, Kimberly
Published in Cancer discovery (01.06.2021)
Published in Cancer discovery (01.06.2021)
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Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Mabe, Nathaniel W, Huang, Min, Dalton, Guillermo N, Alexe, Gabriela, Schaefer, Daniel A, Geraghty, Anna C, Robichaud, Amanda L, Conway, Amy S, Khalid, Delan, Mader, Marius M, Belk, Julia A, Ross, Kenneth N, Sheffer, Michal, Linde, Miles H, Ly, Nghi, Yao, Winnie, Rotiroti, Maria Caterina, Smith, Benjamin A H, Wernig, Marius, Bertozzi, Carolyn R, Monje, Michelle, Mitsiades, Constantine S, Majeti, Ravindra, Satpathy, Ansuman T, Stegmaier, Kimberly, Majzner, Robbie G
Published in Nature cancer (01.08.2022)
Published in Nature cancer (01.08.2022)
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Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma
Pikman, Yana, Conway, Amy Saur, Robichaud, Amanda L., Kitara, Samuel, Church, Alanna J., Kennedy, Alyssa L., Silverman, Lewis B., Billett, Amy L., Weinstock, David M., Harris, Marian H., Stegmaier, Kimberly
Published in Blood advances (14.04.2020)
Published in Blood advances (14.04.2020)
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TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
Seong, Bo Kyung A., Dharia, Neekesh V., Lin, Shan, Donovan, Katherine A., Chong, Shasha, Robichaud, Amanda, Conway, Amy, Hamze, Amanda, Ross, Linda, Alexe, Gabriela, Adane, Biniam, Nabet, Behnam, Ferguson, Fleur M., Stolte, Björn, Wang, Emily Jue, Sun, Jialin, Darzacq, Xavier, Piccioni, Federica, Gray, Nathanael S., Fischer, Eric S., Stegmaier, Kimberly
Published in Cancer cell (13.09.2021)
Published in Cancer cell (13.09.2021)
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Establishing an AML Ex Vivo Platform to Generate Physiologically Relevant Models
Tavana, Omid, Willis, Brandon, Liu, Siyu, Christie, Amanda, Andersen, Courtney L, Roderick-Richardson, Justine, Robichaud, Amanda, Prickett, Laura, Reimer, Corinne, Drew, Lisa
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
Malone, Clare F, Kim, Minjee, Alexe, Gabriela, Engel, Kathleen, Forman, Alexandra B, Robichaud, Amanda, Conway, Amy Saur, Goodale, Amy, Meyer, Ashleigh, Khalid, Delan, Thayakumar, Allen, Hatcher, John M, Gray, Nathanael S, Piccioni, Federica, Stegmaier, Kimberly
Published in Cancer research (Chicago, Ill.) (18.01.2023)
Published in Cancer research (Chicago, Ill.) (18.01.2023)
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Abstract B50: Targeting EWS/FLI fusion oncoprotein stability/degradation in Ewing sarcoma
Seong, Bo Kyung Alex, Lin, Shan, Donovan, Katherine, Robichaud, Amanda, Stolte, Bjorn, Wang, Emily, Dharia, Neekesh, Nabet, Behnam, Piccioni, Federica, Gray, Nathanael, Fischer, Eric, Stegmaier, Kimberly
Published in Cancer research (Chicago, Ill.) (15.07.2020)
Published in Cancer research (Chicago, Ill.) (15.07.2020)
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Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Cremer, Anjali, Ellegast, Jana M, Alexe, Gabriela, Frank, Elizabeth S, Ross, Linda, Chu, S Haihua, Pikman, Yana, Robichaud, Amanda, Goodale, Amy, Häupl, Björn, Mohr, Sebastian, Rao, Arati V, Walker, Alison R, Blachly, James S, Piccioni, Federica, Armstrong, Scott A, Byrd, John C, Oellerich, Thomas, Stegmaier, Kimberly
Published in Cancer discovery (01.02.2020)
Published in Cancer discovery (01.02.2020)
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Abstract 2318: EP300 selectively controls the enhancer landscape of high risk neuroblastoma
Durbin, Adam D., Wang, Tingjian, Wimalasena, Virangika K., Zimmerman, Mark W., Li, Deyao, Dharia, Neekesh V., Mariani, Luca, Park, Paul M., Sigua, Logan H., Morita, Ken, Conway, Amy S., Robichaud, Amanda L., Perez-Atayde, Antonio, Bikowitz, Melissa, Quinn, Taylor, Wiest, Olaf, Schonbrunn, Ernst, Bulyk, Martha, Abraham, Brian J., Stegmaier, Kimberly, Look, A. Thomas, Qi, Jun
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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