JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
Manthey, Carl L, Johnson, Dana L, Illig, Carl R, Tuman, Robert W, Zhou, Zhao, Baker, Judith F, Chaikin, Margery A, Donatelli, Robert R, Franks, Carol F, Zeng, Lee, Crysler, Carl, Chen, Yanmin, Yurkow, Edward J, Boczon, Lisa, Meegalla, Sanath K, Wilson, Kenneth J, Wall, Mark J, Chen, Jinsheng, Ballentine, Shelley K, Ott, Heidi, Baumann, Christian, Lawrence, Danielle, Tomczuk, Bruce E, Molloy, Christopher J
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Published in Molecular cancer therapeutics (01.11.2009)
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Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats
Santulli, Rosemary J, Kinney, William A, Ghosh, Shyamali, Decorte, Bart L, Liu, Li, Tuman, Robert W A, Zhou, Zhao, Huebert, Norman, Bursell, Sven E, Clermont, Alan C, Grant, Maria B, Shaw, Lynn C, Mousa, Shaker A, Galemmo, Jr, Robert A, Johnson, Dana L, Maryanoff, Bruce E, Damiano, Bruce P
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Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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Oral Coadministration of β-Glucuronidase to Increase Exposure of Extensively Glucuronidated Drugs that Undergo Enterohepatic Recirculation
Eichenbaum, Gary, Hsu, C.-P., Subrahmanyam, Vangala, Chen, Jing, Scicinski, Jan, Galemmo, Robert A., Tuman, Robert W., Johnson, Dana L.
Published in Journal of pharmaceutical sciences (01.07.2012)
Published in Journal of pharmaceutical sciences (01.07.2012)
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Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2) fail to inhibit endothelial cell proliferation or formation of microvessels from rat aortic rings in vitro
GARRABRANT, Thomas, TUMAN, Robert W, LUDOVICI, Don, TOMINOVICH, Rose, SIMONEAUX, Richard L, GALEMMO, Robert A, JOHNSON, Dana L
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Published in Angiogenesis (London) (2004)
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(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells
Ho, Chih Y, Ludovici, Donald W, Maharoof, Umar S. M, Mei, Jay, Sechler, Jan L, Tuman, Robert W, Strobel, Eric D, Andraka, Laura, Yen, Hwa-Kwo, Leo, Gregory, Li, Jian, Almond, Harold, Lu, Hong, DeVine, Ann, Tominovich, Rose M, Baker, Judith, Emanuel, Stuart, Gruninger, Robert H, Middleton, Steven A, Johnson, Dana L, Galemmo, Robert A
Published in Journal of medicinal chemistry (29.12.2005)
Published in Journal of medicinal chemistry (29.12.2005)
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A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models
Stuart Emanuel, Robert H. Gruninger, Angel Fuentes-Pesquera, Peter J. Connolly, Jennifer A. Seamon, Susan Hazel, Rose Tominovich, Beth Hollister, Cheryl Napier, Michael R. D'Andrea, Michael Reuman, Gilles Bignan, Robert Tuman, Dana Johnson, David Moffatt, Mark Batchelor, Anne Foley, James O'Connell, Rodger Allen, Martin Perry, Linda Jolliffe, Steven A. Middleton
Published in Molecular pharmacology (01.09.2004)
Published in Molecular pharmacology (01.09.2004)
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Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis
D'Andrea, Michael R, Mei, Jay M, Tuman, Robert W, Galemmo, Robert A, Johnson, Dana L
Published in Molecular cancer therapeutics (01.08.2005)
Published in Molecular cancer therapeutics (01.08.2005)
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Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins
De Corte, Bart L., Kinney, William A., Liu, Li, Ghosh, Shyamali, Brunner, Livia, Hoekstra, William J., Santulli, Rosemary J., Tuman, Robert W., Baker, Judith, Burns, Candace, Proost, Jef C., Tounge, Brett A., Damiano, Bruce P., Maryanoff, Bruce E., Johnson, Dana L., Galemmo, Robert A.
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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1,2,3,4-Tetrahydroquinoline-containing αvβ3 integrin antagonists with enhanced oral bioavailability
GHOSH, Shyamali, SANTULLI, Rosemary J, THOMPSON, Andrew S, CHEN, Ian, KAWAHAMA, Reiko, TUMAN, Robert W, GALEMMO, Robert A, JOHNSON, Dana L, DAMIANO, Bruce P, MARYANOFF, Bruce E, KINNEY, William A, DECORTE, Bart L, LIU, Li, LEWIS, Joan M, PROOST, Jef C, LEO, Gregory C, MASUCCI, John, HAGEMAN, William E
Published in Bioorganic & medicinal chemistry letters (01.12.2004)
Published in Bioorganic & medicinal chemistry letters (01.12.2004)
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Carbohydrate biguanides as potential hypoglycemic agents
Reitz, Allen B, Tuman, Robert W, Marchione, Carol S, Jordan, Alfonzo D, Bowden, Charles R, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (01.09.1989)
Published in Journal of medicinal chemistry (01.09.1989)
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Oral coadministration of [beta]-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation
Eichenbaum, Gary, Hsu, C-P, Subrahmanyam, Vangala, Chen, Jing, Scicinski, Jan, Galemmo Jr, Robert A, Tuman, Robert W, Johnson, Dana L
Published in Journal of pharmaceutical sciences (01.07.2012)
Published in Journal of pharmaceutical sciences (01.07.2012)
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1,2,3,4-Tetrahydroquinoline-containing α Vβ 3 integrin antagonists with enhanced oral bioavailability
Ghosh, Shyamali, Santulli, Rosemary J., Kinney, William A., DeCorte, Bart L., Liu, Li, Lewis, Joan M., Proost, Jef C., Leo, Gregory C., Masucci, John, Hageman, William E., Thompson, Andrew S., Chen, Ian, Kawahama, Reiko, Tuman, Robert W., Galemmo, Robert A., Johnson, Dana L., Damiano, Bruce P., Maryanoff, Bruce E.
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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3 Architectural Design Horror Stories and How to Prevent Them
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1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability
Ghosh, Shyamali, Santulli, Rosemary J, Kinney, William A, Decorte, Bart L, Liu, Li, Lewis, Joan M, Proost, Jef C, Leo, Gregory C, Masucci, John, Hageman, William E, Thompson, Andrew S, Chen, Ian, Kawahama, Reiko, Tuman, Robert W, Galemmo, Jr, Robert A, Johnson, Dana L, Damiano, Bruce P, Maryanoff, Bruce E
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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Synthesis and Anti-Angiogenic Activity of 6-(1,2,4-Thiadiazol-5-yl)-3-amino pyridazine Derivatives
Bongartz, Jean-Pierre, Stokbroekx, Raymond, Van der Aa, Marcel, Luyckx, Marcel, Willems, Marc, Ceusters, Marc, Meerpoel, Lieven, Smets, Gerda, Jansen, Tine, Wouters, Walter, Bowden, Charlie, Valletta, Lisa, Herb, Mark, Tominovich, Rose, Tuman, Robert
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins
De Corte, Bart L, Kinney, William A, Liu, Li, Ghosh, Shyamali, Brunner, Livia, Hoekstra, William J, Santulli, Rosemary J, Tuman, Robert W, Baker, Judith, Burns, Candace, Proost, Jef C, Tounge, Brett A, Damiano, Bruce P, Maryanoff, Bruce E, Johnson, Dana L, Galemmo, Jr, Robert A
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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