State of the art in African trypanosome drug discovery
Jacobs, Robert T, Nare, Bakela, Phillips, Margaret A
Published in Current topics in medicinal chemistry (01.05.2011)
Published in Current topics in medicinal chemistry (01.05.2011)
Get more information
Journal Article
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.
Published in Nature communications (27.06.2019)
Published in Nature communications (27.06.2019)
Get full text
Journal Article
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate
Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Freund, Yvonne R, Berry, Pamela, Ciaravino, Vic, Erve, John C. L, Rosenthal, Philip J, Campo, Brice, Gamo, Francisco-Javier, Sanz, Laura M, Cao, Jianxin
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
Get full text
Journal Article
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis
Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Published in PLoS neglected tropical diseases (01.06.2011)
Published in PLoS neglected tropical diseases (01.06.2011)
Get full text
Journal Article
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Zhang, Ning, Zoltner, Martin, Leung, Ka-Fai, Scullion, Paul, Hutchinson, Sebastian, Del Pino, Ricardo C, Vincent, Isabel M, Zhang, Yong-Kang, Freund, Yvonne R, Alley, Michael R K, Jacobs, Robert T, Read, Kevin D, Barrett, Michael P, Horn, David, Field, Mark C
Published in PLoS pathogens (01.02.2018)
Published in PLoS pathogens (01.02.2018)
Get full text
Journal Article
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis
Ehrens, Alexandra, Lunde, Christopher S, Jacobs, Robert T, Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J, Lenz, Franziska, Fendler, Martina, Turner, Joseph D, Ward, Stephen A, Taylor, Mark J, Freund, Yvonne R, Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J, Hoerauf, Achim, Hübner, Marc P
Published in PLoS neglected tropical diseases (01.01.2020)
Published in PLoS neglected tropical diseases (01.01.2020)
Get full text
Journal Article
Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents
Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Freund, Yvonne R., Chen, Daitao, Orr, Matthew D., Jacobs, Robert T., Zhang, Yong-Kang, Hernandez, Vincent, Liu, Yang, Wu, Anne, Bu, Wei, Liu, Liang, Jarnagin, Kurt, Plattner, Jacob J.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Get full text
Journal Article
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Mowbray, Charles E, Braillard, Stéphanie, Glossop, Paul A, Whitlock, Gavin A, Jacobs, Robert T, Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J, Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H, Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
Get full text
Journal Article
Development of novel drugs for human African trypanosomiasis
Brun, Reto, Don, Robert, Jacobs, Robert T, Wang, Michael Zhuo, Barrett, Michael P
Published in Future microbiology (01.06.2011)
Published in Future microbiology (01.06.2011)
Get full text
Journal Article
Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents
Qiao, Zhitao, Wang, Qi, Zhang, Fenglong, Wang, Zhongli, Bowling, Tana, Nare, Bakela, Jacobs, Robert T, Zhang, Jiong, Ding, Dazhong, Liu, Yangang, Zhou, Huchen
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
Get full text
Journal Article
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)
Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Get full text
Journal Article
Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles
Van Bocxlaer, Katrien, Gaukel, Eric, Hauser, Deirdre, Park, Seong Hee, Schock, Sara, Yardley, Vanessa, Randolph, Ryan, Plattner, Jacob J, Merchant, Tejal, Croft, Simon L, Jacobs, Robert T, Wring, Stephen A
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Get full text
Journal Article
New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones
Pou, Sovitj, Dodean, Rozalia A, Frueh, Lisa, Liebman, Katherine M, Gallagher, Rory T, Jin, Haihong, Jacobs, Robert T, Nilsen, Aaron, Stuart, David R, Doggett, J. Stone, Riscoe, Michael K, Winter, Rolf W
Published in Organic process research & development (20.08.2021)
Published in Organic process research & development (20.08.2021)
Get full text
Journal Article
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines
Priebbenow, Daniel L, Mathiew, Mitch, Shi, Da-Hua, Harjani, Jitendra R, Beveridge, Julia G, Chavchich, Marina, Edstein, Michael D, Duffy, Sandra, Avery, Vicky M, Jacobs, Robert T, Brand, Stephen, Shackleford, David M, Wang, Wen, Zhong, Longjin, Lee, Given, Tay, Erin, Barker, Helena, Crighton, Elly, White, Karen L, Charman, Susan A, De Paoli, Amanda, Creek, Darren J, Baell, Jonathan B
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
Get full text
Journal Article
Novel Small Molecule Inhibitors of Caspase-3 Block Cellular and Biochemical Features of Apoptosis
Scott, Clay W, Sobotka-Briner, Cindy, Wilkins, Deidre E, Jacobs, Robert T, Folmer, James J, Frazee, William J, Bhat, Ratan V, Ghanekar, Smita V, Aharony, David
Published in The Journal of pharmacology and experimental therapeutics (01.01.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2003)
Get full text
Journal Article
Boron-based drugs as antiprotozoals
Jacobs, Robert T, Plattner, Jacob J, Keenan, Martine
Published in Current opinion in infectious diseases (01.12.2011)
Published in Current opinion in infectious diseases (01.12.2011)
Get more information
Journal Article
Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads
Butler, Michelle M, Waidyarachchi, Samanthi L., Shao, Jinfeng, Nguyen, Son T., Ding, Xiaoyuan, Cardinale, Steven C., Morin, Lucas R., Kwasny, Steven M., Ito, Mai, Gezelle, Jeanine, Jiminez-Diaz, Maria B., Angulo-Barturen, Inigo, Jacobs, Robert T., Burrows, Jeremy N., Aron, Zachary D., Bowlin, Terry L., Desai, Sanjay A.
Published in Molecular pharmacology (01.09.2022)
Published in Molecular pharmacology (01.09.2022)
Get full text
Journal Article
Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation
Milano, Joseph, McKay, Jenny, Dagenais, Claude, Foster-Brown, Linda, Pognan, Francois, Gadient, Reto, Jacobs, Robert T., Zacco, Anna, Greenberg, Barry, Ciaccio, Paul J.
Published in Toxicological sciences (01.11.2004)
Published in Toxicological sciences (01.11.2004)
Get full text
Journal Article
Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis
Jacobs, Robert T, Lunde, Christopher S, Freund, Yvonne R, Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S, Berry, Pamela W, Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J, Ford, Louise, Johnston, Kelly L, Cook, Darren A. N, Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F, Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J, Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P, McNamara, Case W, Bakowski, Malina A, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
Get full text
Journal Article